Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0058 | 0.0424 | 0.1061 | |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0284 | 0.2769 | 0.9934 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0275 | 0.2673 | 0.5 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0284 | 0.2769 | 0.5 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0284 | 0.2769 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0275 | 0.2673 | 0.9589 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0275 | 0.2673 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0157 | 0.0564 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0284 | 0.2769 | 0.9934 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0284 | 0.2769 | 0.5 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2788 | 1 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0284 | 0.2769 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.2788 | 0.2672 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0284 | 0.2769 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0424 | 0.1022 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0284 | 0.2769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0157 | 0.0564 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0284 | 0.2769 | 0.9934 |
Onchocerca volvulus | 0.0275 | 0.2673 | 1 | |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0284 | 0.2769 | 0.5 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0275 | 0.2673 | 0.9589 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0424 | 0.1522 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0284 | 0.2769 | 0.993 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0157 | 0.0564 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0284 | 0.2769 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0157 | 0.0564 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0284 | 0.2769 | 0.2654 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0424 | 0.1022 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0284 | 0.2769 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0157 | 0.0564 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0284 | 0.2769 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0275 | 0.2673 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0151 | 0.0542 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0284 | 0.2769 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2788 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0284 | 0.2769 | 0.9934 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.2788 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0928 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.