Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0169 | 0.0421 | 0.1071 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0035 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0421 | 0.1071 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0071 | 0.0178 |
Onchocerca volvulus | 0.0043 | 0.0035 | 0.0033 | |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.131 | 0.3914 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0035 | 0.0085 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0071 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0035 | 0.4946 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0035 | 0.0085 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0071 | 0.0178 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0035 | 0.0085 |
Mycobacterium tuberculosis | Hypothetical protein | 0.131 | 0.3914 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0002 | 0.0256 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0002 | 0.0256 |
Onchocerca volvulus | 0.0043 | 0.0035 | 0.0033 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.0753 | 0.1851 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0035 | 0.0085 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0035 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.131 | 0.3914 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0421 | 0.1071 |
Mycobacterium leprae | Conserved hypothetical protein | 0.131 | 0.3914 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0035 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0035 | 0.0085 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0035 | 0.4946 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0071 | 0.0178 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0035 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.131 | 0.3914 | 1 |
Brugia malayi | Thioredoxin family protein | 0.131 | 0.3914 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0035 | 0.4946 |
Mycobacterium tuberculosis | Long conserved protein | 0.131 | 0.3914 | 1 |
Giardia lamblia | Transglutaminase/protease, putative | 0.131 | 0.3914 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.131 | 0.3914 | 1 |
Giardia lamblia | Hypothetical protein | 0.131 | 0.3914 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0035 | 0.4946 |
Schistosoma mansoni | hypothetical protein | 0.131 | 0.3914 | 1 |
Mycobacterium ulcerans | transglutaminase family protein | 0.131 | 0.3914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0035 | 0.4946 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0035 | 0.0085 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0002 | 0.0256 |
Mycobacterium ulcerans | hypothetical protein | 0.131 | 0.3914 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0035 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0035 | 0.4946 |
Echinococcus multilocularis | Transglutaminase | 0.131 | 0.3914 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0071 | 0.0178 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0071 | 0.0178 |
Echinococcus granulosus | Transglutaminase | 0.131 | 0.3914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0035 | 0.4946 |
Mycobacterium tuberculosis | Conserved protein | 0.131 | 0.3914 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0071 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0035 | 0.4946 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.131 | 0.3914 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.131 | 0.3914 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0071 | 1 |
Onchocerca volvulus | 0.0043 | 0.0035 | 0.0033 | |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0035 | 0.0085 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0071 | 0.0178 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0035 | 0.5 |
Echinococcus granulosus | geminin | 0.0169 | 0.0421 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.