Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.4546 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0237 | 0.6681 | 0.6681 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.0706 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1731 | 0.1996 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.4546 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2829 | 0.3772 |
Brugia malayi | isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.0933 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.3293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0479 | 0.0442 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0497 | 0.0497 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0047 | 0.0933 | 0.4546 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.3293 | 0.3293 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.011 | 0.2829 | 0.2829 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0269 | 0.0269 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1731 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0497 | 0.0497 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0047 | 0.0933 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1731 | 0.4413 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1731 | 0.4413 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.011 | 0.2829 | 0.8341 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0346 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.011 | 0.2829 | 0.2802 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.3293 | 0.3267 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3293 | 0.4522 |
Onchocerca volvulus | 0.0033 | 0.0497 | 0.5 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.1562 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.3293 | 0.3267 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.1562 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3293 | 0.4522 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1731 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.0933 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0047 | 0.0933 | 0.1562 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0039 | 0.0039 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0047 | 0.0933 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2829 | 0.3772 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2829 | 0.3772 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2829 | 0.3772 |
Brugia malayi | Latrophilin receptor protein 2 | 0.011 | 0.2829 | 0.2829 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0269 | 0.0231 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1731 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3293 | 0.4522 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0497 | 0.046 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0047 | 0.0933 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.3293 | 0.3267 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2829 | 0.2802 |
Brugia malayi | RNA binding protein | 0.0125 | 0.3293 | 0.3293 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0047 | 0.0933 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.011 | 0.2829 | 0.8341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3293 | 0.4522 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.1562 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1731 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.011 | 0.2829 | 0.8341 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.3293 | 0.3293 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0497 | 0.046 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0497 | 0.046 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.011 | 0.2829 | 0.8341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3293 | 0.4522 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0346 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0047 | 0.0933 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.1731 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0237 | 0.6681 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.011 | 0.2829 | 0.8341 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1731 | 0.1996 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.1562 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.3293 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.0898 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0047 | 0.0933 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0047 | 0.0933 | 0.1562 |
Echinococcus granulosus | GPCR family 2 | 0.011 | 0.2829 | 0.8341 |
Onchocerca volvulus | 0.0033 | 0.0497 | 0.5 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.1731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.6681 | 0.6668 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.