Detailed information for compound 1424444

Basic information

Technical information
  • TDR Targets ID: 1424444
  • Name: ethyl 2-[2-(3-chlorophenyl)-3-(furan-2-carbon yl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]-4-methyl- 1,3-thiazole-5-carboxylate
  • MW: 472.898 | Formula: C22H17ClN2O6S
  • H donors: 1 H acceptors: 5 LogP: 4.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(nc1C)N1C(=O)C(=C(C1c1cccc(c1)Cl)C(=O)c1ccco1)O
  • InChi: 1S/C22H17ClN2O6S/c1-3-30-21(29)19-11(2)24-22(32-19)25-16(12-6-4-7-13(23)10-12)15(18(27)20(25)28)17(26)14-8-5-9-31-14/h4-10,16,27H,3H2,1-2H3
  • InChiKey: NIEIZHIJRRGXFB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 2-[2-(3-chlorophenyl)-3-(furan-2-carbonyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]-4-methyl-thiazole-5-carboxylate
  • 2-[2-(3-chlorophenyl)-3-(2-furyl-oxomethyl)-4-hydroxy-5-oxo-2H-pyrrol-1-yl]-4-methyl-5-thiazolecarboxylic acid ethyl ester
  • 2-[2-(3-chlorophenyl)-3-(furan-2-carbonyl)-4-hydroxy-5-keto-3-pyrrolin-1-yl]-4-methyl-thiazole-5-carboxylic acid ethyl ester
  • ethyl 2-[2-(3-chlorophenyl)-3-furan-2-ylcarbonyl-4-hydroxy-5-oxo-2H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
  • STOCK2S-46465

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans hypothetical protein Starlite/ChEMBL No references
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major basic transcription factor 3a, putative 0.0042 0.07 0.1474
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.254 0.2462
Echinococcus granulosus tar DNA binding protein 0.0072 0.2588 0.2588
Loa Loa (eye worm) RNA binding protein 0.0072 0.2588 0.251
Brugia malayi RNA binding protein 0.0072 0.2588 0.251
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 1 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0046 0.0921 0.1938
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.4753 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.1031 0.1031
Schistosoma mansoni tar DNA-binding protein 0.0072 0.2588 0.251
Mycobacterium tuberculosis Probable aminotransferase 0.0155 0.7891 1
Echinococcus granulosus aminopeptidase N 0.007 0.2503 0.2503
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.07 0.0447
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.07 0.1474
Trypanosoma brucei Aminopeptidase M1, putative 0.007 0.2503 0.4697
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.2588 0.251
Loa Loa (eye worm) hypothetical protein 0.0071 0.254 0.2462
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.007 0.2503 0.5267
Brugia malayi Peptidase family M1 containing protein 0.007 0.2503 0.2425
Brugia malayi beta-NAC-like protein 0.0042 0.07 0.0604
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0155 0.7891 1
Schistosoma mansoni heat shock protein 0.0039 0.0511 0.0412
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.07 0.0888
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.007 0.2503 0.5267
Treponema pallidum heat shock protein 90 0.0031 0 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 1 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.007 0.2503 0.4697
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0103
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.007 0.2503 0.5267
Trypanosoma cruzi aminopeptidase, putative 0.007 0.2503 0.5267
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0921 0.0827
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0511 0.1074
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Loa Loa (eye worm) aminopeptidase N 0.007 0.2503 0.2425
Schistosoma mansoni tar DNA-binding protein 0.0072 0.2588 0.251
Echinococcus multilocularis aminopeptidase N 0.007 0.2503 0.2503
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 1 1
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.07 0.0952
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0511 0.1074
Schistosoma mansoni hypothetical protein 0.0047 0.1031 0.0937
Schistosoma mansoni tar DNA-binding protein 0.0072 0.2588 0.251
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.007 0.2503 0.2503
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0046 0.0921 0.0827
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.464 0.4584
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0155 0.7891 1
Schistosoma mansoni heat shock protein 0.0039 0.0511 0.0412
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.1031 0.1031
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.464 0.4584
Schistosoma mansoni transcription factor btf3 0.0042 0.07 0.0604
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0155 0.7891 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.464 0.4584
Loa Loa (eye worm) hypothetical protein 0.0106 0.4753 0.4698
Echinococcus multilocularis heat shock protein 90 0.0039 0.0511 0.0511
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.4753 1
Brugia malayi TAR-binding protein 0.0072 0.2588 0.251
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0511 0.1074
Trypanosoma cruzi Aminopeptidase M1, putative 0.007 0.2503 0.5267
Echinococcus multilocularis tar DNA binding protein 0.0072 0.2588 0.2588
Trypanosoma brucei Aminopeptidase M1, putative 0.007 0.2503 0.4697
Echinococcus granulosus heat shock protein 0.0039 0.0511 0.0511
Echinococcus granulosus heat shock protein 90 0.0039 0.0511 0.0511
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.007 0.2503 0.3173
Leishmania major hypothetical protein, conserved 0.0106 0.4753 1
Echinococcus multilocularis transcription factor btf3 0.0042 0.07 0.07
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0511 0.1074
Onchocerca volvulus 0.007 0.2503 0.5
Mycobacterium ulcerans hypothetical protein 0.0155 0.7891 1
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.07 0.1474
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Brugia malayi Peptidase family M1 containing protein 0.007 0.2503 0.2425
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.007 0.2503 0.3173
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.007 0.2503 0.3173
Loa Loa (eye worm) hypothetical protein 0.0104 0.464 0.4584
Schistosoma mansoni endoplasmin 0.0039 0.0511 0.0412
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0511 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.007 0.2503 0.2425
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.4753 1
Loa Loa (eye worm) TAR-binding protein 0.0072 0.2588 0.251
Entamoeba histolytica aminopeptidase, putative 0.007 0.2503 1
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0511 0.0412
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0921 0.0921
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.4753 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0103 0.0103
Loa Loa (eye worm) endoplasmin 0.0039 0.0511 0.0412
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Onchocerca volvulus 0.007 0.2503 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.4753 1
Schistosoma mansoni hypothetical protein 0.0071 0.254 0.2462
Brugia malayi hypothetical protein 0.0068 0.2361 0.2281
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.007 0.2503 0.2425
Schistosoma mansoni tar DNA-binding protein 0.0072 0.2588 0.251
Brugia malayi hypothetical protein 0.0106 0.4753 0.4698
Loa Loa (eye worm) hypothetical protein 0.0046 0.0921 0.0827
Echinococcus multilocularis heat shock protein 0.0039 0.0511 0.0511
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.4753 1
Brugia malayi heat shock protein 90 0.0039 0.0511 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.07 0.0888
Schistosoma mansoni tar DNA-binding protein 0.0072 0.2588 0.251
Entamoeba histolytica hypothetical protein 0.0042 0.07 0.0952
Echinococcus granulosus GPCR family 2 0.0033 0.0103 0.0103
Brugia malayi hypothetical protein 0.007 0.2503 0.2425
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.07 0.0447
Toxoplasma gondii NAC domain-containing protein 0.0042 0.07 0.0447
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.4753 1
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0155 0.7891 1
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.07 0.0447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0103
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0511 0.0647
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0103
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0511 0.1074
Loa Loa (eye worm) ICD-1 protein 0.0042 0.07 0.0604
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.2503 0.2503
Brugia malayi Endoplasmin precursor 0.0039 0.0511 0.0412
Echinococcus granulosus transcription factor btf3 0.0042 0.07 0.07
Leishmania major heat shock protein 83-1 0.0039 0.0511 0.1074
Schistosoma mansoni endoplasmin 0.0039 0.0511 0.0412
Loa Loa (eye worm) hypothetical protein 0.0046 0.0921 0.0827
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.2588 0.251
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.07 0.0888
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.2503 0.2503

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.597 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) = 5.263 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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