Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0788 | 0.0788 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0286 | 0.2277 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0574 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.2091 | 0.7107 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0788 | 0.2679 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0286 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0286 | 0.2277 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0574 | 0.4571 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0788 | 0.0788 |
Trypanosoma brucei | homoserine kinase | 0.0021 | 0 | 0.5 |
Giardia lamblia | Mevalonate kinase | 0.0021 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.2091 | 0.7107 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0788 | 0.0788 |
Trypanosoma cruzi | galactokinase, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | homoserine kinase | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0286 | 0.0286 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0574 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1255 | 0.4267 |
Leishmania major | galactokinase-like protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0286 | 0.0286 |
Trypanosoma cruzi | galactokinase, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0788 | 0.6278 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0574 | 1 |
Trypanosoma brucei | phosphomevalonate kinase protein, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0286 | 0.0972 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0286 | 0.0286 |
Wolbachia endosymbiont of Brugia malayi | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0164 | 0.3701 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0788 | 0.2679 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.2942 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.2091 | 0.7107 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0788 | 0.0788 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.2942 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.2091 | 0.7107 |
Trichomonas vaginalis | galactokinase, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0286 | 0.0972 |
Toxoplasma gondii | GHMP kinase, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0286 | 0.0286 |
Treponema pallidum | hypothetical protein | 0.0164 | 0.3701 | 0.5 |
Toxoplasma gondii | GHMP kinase, N-terminal domain-containing protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0574 | 0.0574 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0286 | 0.0972 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0286 | 0.2277 |
Trichomonas vaginalis | galactokinase, putative | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0164 | 0.3701 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0788 | 0.6278 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0788 | 0.6278 |
Trypanosoma cruzi | homoserine kinase | 0.0021 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0574 | 0.195 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0574 | 0.4571 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0995 | 0.7924 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0286 | 0.0286 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Leishmania major | phosphomevalonate kinase protein, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.1255 | 1 |
Trichomonas vaginalis | galactokinase, putative | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.006 | 0.0995 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.1255 | 0.4267 |
Trichomonas vaginalis | galactokinase, putative | 0.0021 | 0 | 0.5 |
Leishmania major | mevalonate kinase, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0286 | 0.2277 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.2942 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0286 | 0.0972 |
Trypanosoma cruzi | mevalonate kinase, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0574 | 0.0574 |
Leishmania major | homoserine kinase, putative | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative | 0.0143 | 0.3151 | 0.5 |
Mycobacterium leprae | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0164 | 0.3701 | 0.5 |
Mycobacterium tuberculosis | Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) | 0.0143 | 0.3151 | 1 |
Chlamydia trachomatis | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 0.0152 | 0.3384 | 0.5 |
Plasmodium vivax | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative | 0.0143 | 0.3151 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0574 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0995 | 0.3381 |
Trypanosoma brucei | mevalonate kinase, putative | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.005 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.