Detailed information for compound 1429662

Basic information

Technical information
  • TDR Targets ID: 1429662
  • Name: (4S,5R,6R)-N-(1H-benzimidazol-2-ylmethyl)-4-( 1-benzothiophen-3-yl)-6-ethoxy-5-(3-hydroxypr opyl)-5,6-dihydro-4H-pyran-2-carboxamide
  • MW: 491.602 | Formula: C27H29N3O4S
  • H donors: 3 H acceptors: 3 LogP: 4.52 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC[C@H]1[C@H](OCC)OC(=C[C@@H]1c1csc2c1cccc2)C(=O)NCc1nc2c([nH]1)cccc2
  • InChi: 1S/C27H29N3O4S/c1-2-33-27-18(9-7-13-31)19(20-16-35-24-12-6-3-8-17(20)24)14-23(34-27)26(32)28-15-25-29-21-10-4-5-11-22(21)30-25/h3-6,8,10-12,14,16,18-19,27,31H,2,7,9,13,15H2,1H3,(H,28,32)(H,29,30)/t18-,19+,27-/m1/s1
  • InChiKey: JDWCBHXJTUFEHW-VXLXPWSCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4S,5R,6R)-N-(1H-benzimidazol-2-ylmethyl)-4-(benzothiophen-3-yl)-6-ethoxy-5-(3-hydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,5R,6R)-N-(1H-benzimidazol-2-ylmethyl)-4-(3-benzothiophenyl)-6-ethoxy-5-(3-hydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxamide
  • MLS000834581
  • SMR000442113

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0507 0.1366 0.1366
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.028 0.0154
Brugia malayi endochitinase 0.0076 0.0035 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Echinococcus multilocularis expressed protein 0.0393 0.1015 0.1362
Brugia malayi proprotein convertase 2 0.0624 0.1727 0.171
Loa Loa (eye worm) hypothetical protein 0.0238 0.0534 0.0534
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0124 0.0182 0.0182
Echinococcus multilocularis epidermal growth factor receptor 0.0196 0.0406 0.0529
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0976 0.2816 0.4146
Loa Loa (eye worm) chitinase I 0.0076 0.0035 0.0035
Echinococcus granulosus G protein coupled receptor kinase 1 0.0083 0.0055 0.0049
Onchocerca volvulus Putative endochitinase 0.0076 0.0035 1
Loa Loa (eye worm) hypothetical protein 0.0976 0.2816 0.2816
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Brugia malayi Kelch motif family protein 0.0507 0.1366 0.1349
Echinococcus granulosus beta-adrenergic receptor kinase 0.0124 0.0182 0.0223
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0206 0.0435 0.2526
Echinococcus multilocularis integrin alpha ps 0.0236 0.0528 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Echinococcus granulosus furin 0.0976 0.2816 0.3828
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0206 0.0435 0.2526
Echinococcus multilocularis protoporphyrinogen oxidase 0.0338 0.0843 0.1127
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0604 0.1666 0.2253
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0156 0.028 0.028
Echinococcus granulosus neuroendocrine convertase 2 0.0624 0.1727 0.2336
Loa Loa (eye worm) endoprotease bli-4 0.0976 0.2816 0.2816
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Onchocerca volvulus Putative endochitinase 0.0076 0.0035 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Echinococcus multilocularis Furin 1 0.0251 0.0576 0.0762
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0338 0.0843 0.5
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0156 0.028 0.0261
Loa Loa (eye worm) proprotein convertase 2 0.0251 0.0576 0.0576
Brugia malayi endochitinase 0.0076 0.0035 0.0015
Loa Loa (eye worm) hypothetical protein 0.0071 0.0019 0.0019
Toxoplasma gondii cathepsin CPC2 0.0171 0.0327 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0238 0.0534 0.0704
Schistosoma mansoni hypothetical protein 0.0206 0.0435 0.0399
Echinococcus granulosus neuropeptide receptor A26 0.0572 0.1568 0.212
Echinococcus multilocularis fibrillin 1 0.0072 0.0022 0.0003
Brugia malayi endoprotease bli-4 precursor 0.0976 0.2816 0.2802
Brugia malayi Stress-activated protein kinase jnk-1 0.0466 0.1239 0.1222
Echinococcus multilocularis beta adrenergic receptor kinase 0.0124 0.0182 0.0223
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0171 0.0327 0.5
Loa Loa (eye worm) hypothetical protein 0.0606 0.1671 0.1671
Giardia lamblia High cysteine membrane protein Group 2 0.0353 0.0889 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0576 0.3381
Schistosoma mansoni hypothetical protein 0.0236 0.0528 0.0545
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0604 0.1666 0.2253
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0171 0.0327 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0019 0.0019
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0466 0.1239 0.1239
Loa Loa (eye worm) hypothetical protein 0.0372 0.0949 0.0949
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0576 0.3381
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Echinococcus multilocularis integrin alpha 3 0.0842 0.24 0.3258
Loa Loa (eye worm) integrin alpha pat-2 0.1692 0.503 0.503
Giardia lamblia Furin precursor putative serine protease 0.0206 0.0435 0.4785
Echinococcus granulosus expressed protein 0.0393 0.1015 0.1362
Loa Loa (eye worm) hypothetical protein 0.0236 0.0528 0.0528
Schistosoma mansoni tyrosine kinase 0.0196 0.0406 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0251 0.0576 0.062
Brugia malayi hypothetical protein 0.0507 0.1366 0.1349
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0338 0.0843 1
Loa Loa (eye worm) integrin beta-2 0.33 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0576 0.3381
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0507 0.1366 0.1366
Echinococcus granulosus integrin alpha ps 0.0492 0.132 0.178
Echinococcus multilocularis 0.077 0.218 0.2956
Brugia malayi celfurPC protein 0.077 0.218 0.2165
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0576 0.3381
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0684 0.1914 0.2593
Echinococcus granulosus Furin 1 0.0251 0.0576 0.0762
Schistosoma mansoni serine/threonine protein kinase 0.0466 0.1239 0.1663
Loa Loa (eye worm) hypothetical protein 0.083 0.2366 0.2366
Echinococcus granulosus c-Jun N-terminal kinases 0.0466 0.1239 0.1669
Brugia malayi Endochitinase 0.0076 0.0035 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0576 0.3381
Echinococcus granulosus protoporphyrinogen oxidase 0.0293 0.0706 0.0939
Loa Loa (eye worm) hypothetical protein 0.0256 0.0591 0.0591
Chlamydia trachomatis protoporphyrinogen oxidase 0.0338 0.0843 0.5
Onchocerca volvulus Putative endochitinase 0.0076 0.0035 1
Echinococcus granulosus fibrillin 1 0.0072 0.0022 0.0003
Schistosoma mansoni integrin beta subunit 0.1929 0.576 0.8779
Loa Loa (eye worm) hypothetical protein 0.0071 0.0019 0.0019
Brugia malayi Furin-like cysteine rich region family protein 0.0196 0.0406 0.0387
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0083 0.0055 0.0049
Echinococcus multilocularis neuropeptide receptor A26 0.0572 0.1568 0.212
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0251 0.0576 0.3381
Brugia malayi Tachykinin-like peptides receptor 99D 0.0238 0.0534 0.0515
Onchocerca volvulus Putative endochitinase 0.0076 0.0035 1
Loa Loa (eye worm) cuticular endochitinase 0.0076 0.0035 0.0035
Echinococcus multilocularis integrin alpha ps 0.0492 0.132 0.178
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.0539 0.7637
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0115 0.0153 0.0183
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0604 0.1666 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0115 0.0153 0.0153
Echinococcus granulosus integrin alpha ps 0.0236 0.0528 0.0696
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0338 0.0843 0.1041
Trichomonas vaginalis hypothetical protein 0.0206 0.0435 0.2526
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0604 0.1666 1
Echinococcus multilocularis neuropeptide s receptor 0.0572 0.1568 0.212
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0684 0.1914 0.2593
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0206 0.0435 0.2526
Echinococcus granulosus integrin beta 2 0.2435 0.7327 1
Schistosoma mansoni integrin alpha-ps 0.0492 0.132 0.1791
Echinococcus multilocularis integrin alpha ps 0.0492 0.132 0.178
Echinococcus granulosus neuropeptide s receptor 0.0572 0.1568 0.212
Schistosoma mansoni serine-type protease inhibitor 0.2179 0.6535 1
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Schistosoma mansoni integrin alpha-ps 0.0256 0.0591 0.0643
Loa Loa (eye worm) TK/EGFR protein kinase 0.0196 0.0406 0.0406
Entamoeba histolytica chitinase, putative 0.0076 0.0035 0.5
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0115 0.0153 0.0134
Echinococcus granulosus epidermal growth factor receptor 0.0196 0.0406 0.0529
Schistosoma mansoni integrin alpha 0.1098 0.3193 0.4738
Loa Loa (eye worm) hypothetical protein 0.0862 0.2463 0.2463
Echinococcus multilocularis integrin beta 2 0.2435 0.7327 1
Brugia malayi Integrin alpha pat-2 precursor 0.1098 0.3193 0.3179
Schistosoma mansoni serine-type protease inhibitor 0.2179 0.6535 1
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0293 0.0706 1
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0115 0.0153 0.0183
Onchocerca volvulus Putative endochitinase 0.0076 0.0035 1
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0115 0.0153 0.0153
Schistosoma mansoni furin-1 (S08 family) 0.0418 0.109 0.1429
Echinococcus multilocularis neuroendocrine convertase 2 0.0624 0.1727 0.2336
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Loa Loa (eye worm) hypothetical protein 0.0071 0.0019 0.0019
Brugia malayi neuroendocrine convertase 1 precursor 0.0624 0.1727 0.171
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2826 0.384
Echinococcus granulosus integrin alpha 3 0.0842 0.24 0.3258
Brugia malayi Integrin alpha cytoplasmic region family protein 0.083 0.2366 0.2351
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0435 0.2526
Leishmania major chitinase 0.0076 0.0035 0.5
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0466 0.1239 0.1669
Echinococcus granulosus neuropeptide FF receptor 2 0.0238 0.0534 0.0704

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0501 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.