Detailed information for compound 1431905

Basic information

Technical information
  • TDR Targets ID: 1431905
  • Name: (E)-[4-(3-methylpyridin-1-ium-1-yl)-2-oxo-1,3 -thiazol-5-ylidene]methanolate
  • MW: 220.248 | Formula: C10H8N2O2S
  • H donors: 1 H acceptors: 3 LogP: 2.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1sc(nc1[n+]1cccc(c1)C)[O-]
  • InChi: 1S/C10H8N2O2S/c1-7-3-2-4-12(5-7)9-8(6-13)15-10(14)11-9/h2-6H,1H3
  • InChiKey: ZDBSHHFSTGSCND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-[4-(3-methylpyridin-1-ium-1-yl)-2-oxo-1,3-thiazol-5-ylidene]methanolate
  • [4-(3-methylpyridin-1-ium-1-yl)-2-oxo-1,3-thiazol-5-ylidene]methanolate
  • (E)-[4-(3-methylpyridin-1-ium-1-yl)-2-oxo-thiazol-5-ylidene]methanolate
  • (Z)-[4-(3-methylpyridin-1-ium-1-yl)-2-oxo-thiazol-5-ylidene]methanolate
  • [4-(3-methylpyridin-1-ium-1-yl)-2-oxo-thiazol-5-ylidene]methanolate
  • [4-(3-methyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate
  • (E)-[4-(3-methyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate
  • (Z)-[4-(3-methyl-1-pyridin-1-iumyl)-2-oxo-5-thiazolylidene]methanolate
  • (Z)-[2-keto-4-(3-methylpyridin-1-ium-1-yl)thiazol-5-ylidene]methanolate
  • [2-keto-4-(3-methylpyridin-1-ium-1-yl)thiazol-5-ylidene]methanolate
  • (E)-[2-keto-4-(3-methylpyridin-1-ium-1-yl)thiazol-5-ylidene]methanolate
  • STOCK2S-96487
  • BAS 00929318
  • MLS000710654
  • SMR000280421

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens troponin C type 1 (slow) Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens troponin T type 2 (cardiac) Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens troponin I type 3 (cardiac) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_132708 All targets in OG5_132708
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Troponin I homolog Get druggable targets OG5_132708 All targets in OG5_132708
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001978,Troponin,domain-containing Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus granulosus troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus oncosphere protein Tso22e Get druggable targets OG5_129858 All targets in OG5_129858
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Loa Loa (eye worm) troponin Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Troponin family protein Get druggable targets OG5_132708 All targets in OG5_132708
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma mansoni troponin t invertebrate Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Troponin T, skeletal muscle, putative Get druggable targets OG5_129858 All targets in OG5_129858
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Loa Loa (eye worm) troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Echinococcus multilocularis troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Troponin I 4, putative Get druggable targets OG5_132708 All targets in OG5_132708
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Plasmodium falciparum centrin-3 troponin C type 1 (slow) 161 aa 148 aa 33.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.1131 0.1383
Loa Loa (eye worm) troponin I 0.0129 0.4856 0.4856
Schistosoma mansoni kinase 0.0058 0.172 0.2762
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.8182 1
Schistosoma mansoni troponin t invertebrate 0.016 0.6226 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.1131 0.2041
Loa Loa (eye worm) hypothetical protein 0.0129 0.4856 0.4856
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.4198 0.5131
Brugia malayi Troponin T 0.0076 0.2538 0.2538
Echinococcus multilocularis troponin i 0.0129 0.4856 0.5935
Echinococcus granulosus troponin i 0.0129 0.4856 0.5935
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.1131 0.2041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.4198 0.4501
Loa Loa (eye worm) troponin T 0.0076 0.2538 0.2538
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.016 0.6226 0.761
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.4198 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.8182 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.4198 0.6743
Loa Loa (eye worm) troponin 0.0076 0.2538 0.2538
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.1131 0.1817
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.1131 0.1383
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1653 0.2127
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.4198 0.4198
Brugia malayi Troponin T 0.0076 0.2538 0.2538
Loa Loa (eye worm) hypothetical protein 0.0041 0.0977 0.0977
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.1131 0.1817
Schistosoma mansoni hypothetical protein 0.0129 0.4856 0.7799
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.2869 0.3506
Onchocerca volvulus Troponin I homolog 0.0129 0.4856 0.6284
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Schistosoma mansoni troponin I 0.0129 0.4856 0.7799
Schistosoma mansoni tsg101-related 0.007 0.2248 0.3611
Schistosoma mansoni troponin I 0.0129 0.4856 0.7799
Schistosoma mansoni tsg101-related 0.007 0.2248 0.3611
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.4198 1
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.016 0.6226 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.1131 0.0513
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1818 0.1818
Brugia malayi Troponin T 0.0076 0.2538 0.2538
Trypanosoma brucei polo-like protein kinase 0.0114 0.4198 1
Echinococcus granulosus oncosphere protein Tso22e 0.016 0.6226 0.761
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.1131 0.1383
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.1131 0.1383
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.1682 0.1796
Brugia malayi hypothetical protein 0.0084 0.2869 0.2869
Brugia malayi Troponin I 0.0129 0.4856 0.4856
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.1131 0.2041
Giardia lamblia Kinase, PLK 0.0114 0.4198 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.4856 0.4856
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.1131 0.1383
Brugia malayi hypothetical protein 0.0076 0.2538 0.2538
Loa Loa (eye worm) hypothetical protein 0.0076 0.2538 0.2538
Schistosoma mansoni troponin I 0.0129 0.4856 0.7799
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.1131 0.1131
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.4198 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.1131 0.1383
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1818 0.1818
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0084 0.2869 0.2869
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1653 0.2127
Loa Loa (eye worm) hypothetical protein 0.0245 1 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.4198 0.5131
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Schistosoma mansoni tsg101-related 0.0057 0.1682 0.2702
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.1131 0.0513
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.2869 0.3506
Loa Loa (eye worm) hypothetical protein 0.0045 0.1131 0.1131
Schistosoma mansoni troponin I 0.0129 0.4856 0.7799
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.4198 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.1131 0.0513
Schistosoma mansoni hypothetical protein 0.0041 0.0977 0.1569
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.4198 0.4198
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.4198 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.1131 0.2041
Brugia malayi Troponin family protein 0.0129 0.4856 0.4856

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 2.177 uM PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493008, AID493018, AID504382, AID504383] ChEMBL. No reference
EC50 (functional) = 11.5 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6061 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) 75.193 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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