Detailed information for compound 1436417

Basic information

Technical information
  • TDR Targets ID: 1436417
  • Name: 3-methoxy-2-(pyridin-3-ylmethylsulfanyl)quina zolin-4-one
  • MW: 299.348 | Formula: C15H13N3O2S
  • H donors: 0 H acceptors: 2 LogP: 2.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COn1c(SCc2cccnc2)nc2c(c1=O)cccc2
  • InChi: 1S/C15H13N3O2S/c1-20-18-14(19)12-6-2-3-7-13(12)17-15(18)21-10-11-5-4-8-16-9-11/h2-9H,10H2,1H3
  • InChiKey: ZNSQCCUWJYPCOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methoxy-2-(3-pyridylmethylsulfanyl)quinazolin-4-one
  • 3-methoxy-2-(3-pyridylmethylthio)-4-quinazolinone
  • 3-methoxy-2-(3-pyridylmethylthio)quinazolin-4-one
  • MLS000040346
  • SMR000045865
  • ZINC00545580

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0623 0.5346 0.5346
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.1137 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0623 0.5346 0.5345
Entamoeba histolytica cell division protein kinase 2, putative 0.0562 0.4792 0.4791
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0113 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.5416 1
Entamoeba histolytica protein kinase domain containing protein 0.0631 0.5416 0.5415
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0623 0.5346 0.5345
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0562 0.4792 0.4789
Entamoeba histolytica protein kinase, putative 0.0631 0.5416 0.5415
Entamoeba histolytica cell division protein kinase 2, putative 0.0562 0.4792 0.4791
Trichomonas vaginalis CMGC family protein kinase 0.0623 0.5346 0.9867
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0623 0.5346 0.5344
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0068 0.0068
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0631 0.5416 0.5415
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0113 0.0111
Trypanosoma brucei casein kinase I, isoform 2 0.0499 0.4222 0.4219
Trypanosoma brucei cdc2-related kinase 1 0.0562 0.4792 0.4789
Trichomonas vaginalis CMGC family protein kinase 0.0562 0.4792 0.8822
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0562 0.4792 0.4792
Plasmodium vivax glycogen synthase kinase 3, putative 0.0623 0.5346 1
Loa Loa (eye worm) hypothetical protein 0.006 0.025 0.0248
Trypanosoma cruzi casein kinase, putative 0.0499 0.4222 0.4219
Echinococcus granulosus dual specificity 0.1137 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.004 0.0068 0.0068
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0113 0.0084
Loa Loa (eye worm) TK protein kinase 0.0036 0.0035 0.0033
Echinococcus multilocularis casein kinase I delta 0.0499 0.4222 0.4222
Trypanosoma cruzi casein kinase, putative 0.0499 0.4222 0.4219
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0631 0.5416 0.5414
Echinococcus multilocularis cyclin dependent kinase 1 0.0562 0.4792 0.4792
Trypanosoma brucei cdc2-related kinase 3 0.0562 0.4792 0.4789
Plasmodium falciparum casein kinase 1 0.0499 0.4222 0.7895
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0068 0.0068
Trypanosoma cruzi casein kinase, delta isoform, putative 0.047 0.3962 0.3959
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0623 0.5346 0.5346
Echinococcus multilocularis casein kinase I delta 0.0499 0.4222 0.4222
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0562 0.4792 0.8846
Echinococcus granulosus activin receptor type 0.0033 0.0004 0.0004
Echinococcus granulosus casein kinase I alpha 0.0499 0.4222 0.4222
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.5416 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0035 0.0035
Echinococcus granulosus casein kinase I alpha 0.0499 0.4222 0.4222
Echinococcus multilocularis cyclin dependent kinase 0.0562 0.4792 0.4792
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0562 0.4792 0.4789
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0068 0.0068
Brugia malayi SRC-1 0.004 0.0068 0.0039
Echinococcus granulosus dual specificity 0.0631 0.5416 0.5416
Trypanosoma cruzi cdc2-related kinase 3 0.0562 0.4792 0.4789
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.1137 1 1
Echinococcus multilocularis dual specificity 0.0631 0.5416 0.5416
Echinococcus granulosus dual specificity 0.0631 0.5416 0.5416
Trypanosoma cruzi cdc2-related kinase 1 0.0562 0.4792 0.4789
Echinococcus multilocularis protein kinase shaggy 0.0623 0.5346 0.5346
Trichomonas vaginalis CMGC family protein kinase 0.0623 0.5346 0.9867
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.1137 1 1
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0631 0.5416 0.5414
Brugia malayi cell division control protein 2 homolog 0.0562 0.4792 0.4776
Schistosoma mansoni protein kinase 0.0033 0.0004 0.0003
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0499 0.4222 0.4221
Echinococcus granulosus cyclin dependent kinase 5 0.0562 0.4792 0.4792
Echinococcus granulosus tyrosine protein kinase Lyn 0.0068 0.0328 0.0328
Brugia malayi casein kinase 1, delta 0.0499 0.4222 0.4205
Trichomonas vaginalis CK1 family protein kinase 0.0499 0.4222 0.7747
Entamoeba histolytica protein kinase domain containing protein 0.1137 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.004 0.0068 0.0068
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0631 0.5416 0.5403
Entamoeba histolytica protein kinase, putative 0.1137 1 1
Schistosoma mansoni serine/threonine protein kinase 0.1137 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0562 0.4792 0.8822
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.004 0.0068 0.0068
Echinococcus multilocularis dual specificity 0.1137 1 1
Trypanosoma cruzi casein kinase, putative 0.0499 0.4222 0.4219
Loa Loa (eye worm) SRC-1 0.004 0.0068 0.0066
Schistosoma mansoni protein kinase 0.0499 0.4222 0.4221
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.004 0.0068 0.0068
Echinococcus granulosus casein kinase I alpha 0.0499 0.4222 0.4222
Schistosoma mansoni protein kinase 0.0033 0.0004 0.0003
Plasmodium falciparum glycogen synthase kinase 3 0.0623 0.5346 1
Schistosoma mansoni tyrosine kinase 0.004 0.0068 0.0066
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0068 0.0068
Giardia lamblia Kinase, CMGC DYRK 0.0631 0.5416 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0002 0.0002
Echinococcus multilocularis casein kinase I alpha 0.0499 0.4222 0.4222
Schistosoma mansoni cellular tumor antigen P53 0.006 0.025 0.0248
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1137 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.5416 1
Echinococcus multilocularis dual specificity 0.0631 0.5416 0.5416
Echinococcus multilocularis tyrosine protein kinase Fgr 0.004 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Src64B 0.004 0.0068 0.0068
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0562 0.4792 0.4791
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.5416 1
Plasmodium vivax protein kinase Crk2 0.0562 0.4792 0.5069
Giardia lamblia Kinase, CMGC GSK 0.0623 0.5346 0.9867
Echinococcus granulosus tumor protein p63 0.0408 0.3402 0.3402
Loa Loa (eye worm) hypothetical protein 0.0045 0.0113 0.0111
Echinococcus granulosus casein kinase I delta 0.0499 0.4222 0.4222
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0113 0.0113
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0623 0.5346 0.5344
Trypanosoma cruzi casein kinase, putative 0.0499 0.4222 0.4219
Echinococcus granulosus cyclin dependent kinase 0.0562 0.4792 0.4792
Onchocerca volvulus 0.0623 0.5346 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0068 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0562 0.4792 0.4791
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0113 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.5416 1
Trypanosoma cruzi casein kinase, putative 0.0499 0.4222 0.4219
Entamoeba histolytica protein kinase domain containing protein 0.0033 0.0004 0.0002
Echinococcus multilocularis tumor protein p63 0.0408 0.3402 0.3402
Entamoeba histolytica protein kinase, putative 0.1137 1 1
Echinococcus multilocularis casein kinase i 0.0499 0.4222 0.4222
Schistosoma mansoni tyrosine kinase 0.004 0.0068 0.0066
Brugia malayi casein kinase I 0.0499 0.4222 0.4205
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0033 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.1108 0.974 0.974
Echinococcus granulosus casein kinase I delta 0.0499 0.4222 0.4222
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0035 0.0035
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0068 0.0068
Echinococcus multilocularis casein kinase I alpha 0.0499 0.4222 0.4222
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0623 0.5346 0.5345
Schistosoma mansoni serine/threonine protein kinase 0.0499 0.4222 0.4221
Brugia malayi Protein kinase domain containing protein 0.0562 0.4792 0.4776
Brugia malayi protein-tyrosine kinase 0.0036 0.0035 0.0006
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0562 0.4792 0.4791
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0562 0.4792 0.4791
Entamoeba histolytica casein kinase, putative 0.0499 0.4222 0.4221
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.1137 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0562 0.4792 0.8822
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0499 0.4222 0.4219
Echinococcus multilocularis dual specificity 0.0631 0.5416 0.5416
Loa Loa (eye worm) hypothetical protein 0.1108 0.974 0.974
Onchocerca volvulus 0.0499 0.4222 0.7896
Echinococcus granulosus dual specificity 0.0631 0.5416 0.5416
Leishmania major casein kinase, putative 0.0499 0.4222 0.4219
Trichomonas vaginalis CK1 family protein kinase 0.0499 0.4222 0.7747
Schistosoma mansoni serine/threonine protein kinase 0.0562 0.4792 0.4791
Schistosoma mansoni protein kinase 0.0033 0.0004 0.0003
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0035 0.0035
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0113 0.0113
Entamoeba histolytica protein kinase domain containing protein 0.0623 0.5346 0.5345
Toxoplasma gondii casein kinase I 0.0499 0.4222 0.7793
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0113 0.0109
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0033 0.0004 0.0004
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0035 0.0029 0.0027
Giardia lamblia Kinase, CMGC CDK 0.0562 0.4792 0.8822
Onchocerca volvulus 0.006 0.025 0.0464
Onchocerca volvulus 0.047 0.3962 0.741
Plasmodium falciparum protein kinase 5 0.0562 0.4792 0.8962
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0113 0.0109
Giardia lamblia Kinase, CK1 Casein kinase 0.0499 0.4222 0.7747
Echinococcus multilocularis activin receptor type 0.0033 0.0004 0.0004
Echinococcus granulosus cyclin dependent kinase 1 0.0562 0.4792 0.4792
Echinococcus granulosus tyrosine kinase 0.0036 0.0035 0.0035
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.004 0.0068 0.0068
Giardia lamblia Kinase, CMGC GSK 0.0623 0.5346 0.9867
Entamoeba histolytica protein kinase, putative 0.0623 0.5346 0.5345
Echinococcus granulosus casein kinase i 0.0499 0.4222 0.4222
Schistosoma mansoni serine/threonine protein kinase 0.0631 0.5416 0.5416
Echinococcus granulosus twitchin 0.006 0.0254 0.0254
Entamoeba histolytica casein kinase 1, putative 0.0499 0.4222 0.4221
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.5416 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0068 0.0068
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0623 0.5346 0.987
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0113 0.0112
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0035 0.0035
Echinococcus multilocularis cyclin dependent kinase 1 0.0562 0.4792 0.4792
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0631 0.5416 0.5414
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0113 0.0113
Trypanosoma cruzi cdc2-related kinase 3 0.0562 0.4792 0.4789
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0113 0.0113
Trichomonas vaginalis CK1 family protein kinase 0.0499 0.4222 0.7747
Brugia malayi intracellular kinase 0.0623 0.5346 0.5332
Giardia lamblia Kinase, CMGC CDK 0.0562 0.4792 0.8822
Entamoeba histolytica protein kinase domain containing protein 0.0623 0.5346 0.5345
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0631 0.5416 1
Echinococcus multilocularis casein kinase I alpha 0.0499 0.4222 0.4222
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0499 0.4222 0.4221
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.1137 1 1
Trypanosoma brucei protein kinase, putative 0.0623 0.5346 0.5344
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0035 0.0035
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0113 0.0109
Trypanosoma cruzi cdc2-related kinase 1 0.0562 0.4792 0.4789
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0499 0.4222 0.4221
Loa Loa (eye worm) hypothetical protein 0.0533 0.4532 0.4531
Echinococcus multilocularis tyrosine protein kinase Src64B 0.004 0.0068 0.0068
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0113 0.0113
Echinococcus multilocularis cyclin dependent kinase 5 0.0562 0.4792 0.4792
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0002 0.0002
Echinococcus granulosus protein kinase shaggy 0.0623 0.5346 0.5346
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0113 0.0109

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0928 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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