Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0014 | 0.0467 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0309 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0054 | 0.1756 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0309 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3407 | 0.3809 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.893 | 1 | 1 |
Plasmodium falciparum | peptide deformylase | 0.893 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0054 | 1 |
Onchocerca volvulus | 0.0058 | 0.0054 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0014 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0014 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3407 | 0.3809 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0014 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0309 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3407 | 0.3809 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0054 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0309 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0151 | 0.4872 |
Toxoplasma gondii | hypothetical protein | 0.893 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3407 | 0.3809 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0014 | 0.0467 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.893 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.893 | 1 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3407 | 0.3809 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.893 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3407 | 0.3809 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0151 | 0.4872 |
Plasmodium vivax | peptide deformylase, putative | 0.893 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0014 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0151 | 0.4872 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0014 | 0.0467 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0014 | 0.0467 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0014 | 0.2662 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3407 | 0.3809 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0014 | 0.2662 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.893 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0045 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.