Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | slit 2 protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | Thrombospondin N-terminal -like domain containing protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Brugia malayi | laminin alpha chain | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | slit 2 protein | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | pikachurin | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | cell polarity protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | chondroitin sulfate proteoglycan-related | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | abnormal epIthelia family member | 0.0024 | 0.5 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0024 | 0.5 | 0.5 |
Echinococcus granulosus | pikachurin | 0.0024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.5 | 0.5 |
Schistosoma mansoni | slit | 0.0024 | 0.5 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K app (binding) | = 0.00048 uM | In vitro displacement of [3H]-OXO-M from muscarinic acetylcholine receptor in rat cortical homogenates | ChEMBL. | 2319559 |
K app (binding) | = 0.001 uM | In vitro for its ability to displace [3H]-NMS from muscarinic acetylcholine receptor in rat cortical homogenates | ChEMBL. | 2319559 |
Ratio (binding) | = 4100 | The ratio of Kapp([3H]-NMS) / Kapp([3H]-OXO-M) was determined | ChEMBL. | 2319559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.