Detailed view for Bm1_24440

Basic information

TDR Targets ID: 240946
Brugia malayi, laminin alpha chain
Source Database / ID:  GenBank

pI: 6.362 | Length (AA): 3357 | MW (Da): 376311 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00052   Laminin B (Domain IV)
PF00053   Laminin EGF domain
PF00054   Laminin G domain
PF00055   Laminin N-terminal (Domain VI)
PF02210   Laminin G domain
PF06009   Laminin Domain II

Gene Ontology

Mouse over links to read term descriptions.
GO:0031012   extracellular matrix  
GO:0005606   laminin-1 complex  
GO:0005604   basement membrane  
GO:0005578   proteinaceous extracellular matrix  
GO:0005102   receptor binding  
GO:0045995   regulation of embryonic development  
GO:0030334   regulation of cell migration  
GO:0030155   regulation of cell adhesion  
GO:0007155   cell adhesion  

Metabolic Pathways

ECM-receptor interaction (KEGG)

Structural information

Modbase 3D models:

There are 20 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 512 4aqs (A) 29 493 27.00 0 1 0.2859 0.98
43 421 2y38 (A) 47 438 51.00 0 1 0.484898 0.61
48 416 4aqt (A) 50 395 35.00 0 1 0.36472 0.63
99 419 2y38 (A) 120 436 42.00 0 1 0.289621 0.65
580 702 4yep (A) 1233 1362 28.00 0.00076 1 0.38344 -0.29
843 971 1klo (A) 29 166 50.00 0 1 0.552227 -0.06
976 1022 5lf2 (A) 786 832 49.00 0.0000042 1 0.637801 -0.46
1743 1983 2z6e (C) 738 1002 25.00 0.86 0.58 0.12159 0.46
1766 2247 4uxv (A) 44 528 22.00 0.2 1 0.117381 0.94
1846 2087 4tql (A) 9 235 21.00 0.0067 0.98 0.325888 -0.48
2007 2247 5cwm (A) 4 227 25.00 0.42 1 0.30759 -0.38
2086 2255 4uos (A) 3 162 21.00 0.54 0.35 0.34744 -1.24
2134 2242 1sig (A) 146 281 29.00 0.7 0.34 0.323269 -0.09
2225 2862 5mc9 (A) 2094 2680 23.00 0 1 0.300051 0.43
2233 2846 5mc9 (A) 2109 2664 29.00 0 1 0.360701 0.3
2309 2851 2wjs (A) 2190 2695 22.00 0 1 0.147752 0.97
2487 2612 3pve (A) 1462 1590 33.00 0.024 1 0.475334 -0.7
2494 3353 3qcw (A) 297 1087 20.00 0 1 0.221181 1.08
2677 2857 1pz8 (A) 17 194 17.00 0.00029 0.78 0.184917 -0.4
3017 3168 1d2s (A) 30 183 24.00 0.00005 0.99 0.389279 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126876)

Species Accession Gene Product
Brugia malayi Bm1_27925   Laminin-like protein C54D1.5 precursor
Brugia malayi Bm1_24440   laminin alpha chain
Brugia malayi Bm1_38590   laminin-like protein K08C7.3 precursor
Caenorhabditis elegans CELE_K08C7.3   Protein EPI-1, isoform C
Caenorhabditis elegans CELE_C54D1.5   Protein LAM-2
Caenorhabditis elegans CELE_T22A3.8   Protein LAM-3
Drosophila melanogaster Dmel_CG42677   wing blister
Drosophila melanogaster Dmel_CG10236   Laminin A
Drosophila melanogaster Dmel_CG3322   Laminin B2
Echinococcus granulosus EgrG_001132400   laminin
Echinococcus granulosus EgrG_000458400   Laminin subunit gamma
Echinococcus granulosus EgrG_000494300   Pfam-B_16336 domain containing protein
Echinococcus multilocularis EmuJ_000494300   conserved hypothetical protein
Echinococcus multilocularis EmuJ_000458400   Laminin subunit gamma
Echinococcus multilocularis EmuJ_001132400   laminin
Homo sapiens ENSG00000050555   laminin, gamma 3
Homo sapiens ENSG00000112769   laminin, alpha 4
Homo sapiens ENSG00000135862   laminin, gamma 1 (formerly LAMB2)
Homo sapiens ENSG00000196569   laminin, alpha 2
Homo sapiens ENSG00000101680   laminin, alpha 1
Homo sapiens ENSG00000130702   laminin, alpha 5
Homo sapiens ENSG00000053747   laminin, alpha 3
Homo sapiens ENSG00000058085   laminin, gamma 2
Loa Loa (eye worm) LOAG_07978   hypothetical protein
Loa Loa (eye worm) LOAG_05302   hypothetical protein
Loa Loa (eye worm) LOAG_01359   laminin alpha 1 chain
Loa Loa (eye worm) LOAG_02515   abnormal epIthelia family member
Loa Loa (eye worm) LOAG_07250   LAM-2
Mus musculus ENSMUSG00000024421   laminin, alpha 3
Mus musculus ENSMUSG00000019899   laminin, alpha 2
Mus musculus ENSMUSG00000032796   laminin, alpha 1
Mus musculus ENSMUSG00000019846   laminin, alpha 4
Mus musculus ENSMUSG00000015647   laminin, alpha 5
Mus musculus ENSMUSG00000026479   laminin, gamma 2
Mus musculus ENSMUSG00000026840   laminin gamma 3
Mus musculus ENSMUSG00000026478   laminin, gamma 1
Schistosoma japonicum Sjp_0044160   ko:K05635 laminin, gamma 1, putative
Schistosoma japonicum Sjp_0008530   ko:K05637 laminin, alpha 1, putative
Schistosoma japonicum Sjp_0008540   IPR001791,Laminin G;IPR008985,Concanavalin A-like lectin/glucanase,domain-containing
Schistosoma japonicum Sjp_0116780   IPR008211,Laminin, N-terminal,domain-containing
Schistosoma mansoni Smp_143680   laminin
Schistosoma mansoni Smp_163810   laminin gamma-1 chain
Schmidtea mediterranea mk4.012094.00  
Schmidtea mediterranea mk4.042317.00  
Schmidtea mediterranea mk4.002835.01  
Schmidtea mediterranea mk4.008300.01  
Schmidtea mediterranea mk4.015198.01   Usherin
Schmidtea mediterranea mk4.007465.00  
Schmidtea mediterranea mk4.015198.00  
Schmidtea mediterranea mk4.017357.00  
Schmidtea mediterranea mk4.000676.10   Laminin alpha chain
Schmidtea mediterranea mk4.000676.09   Laminin-like protein lam-2
Schmidtea mediterranea mk4.001093.02  
Schmidtea mediterranea mk4.000676.12  
Schmidtea mediterranea mk4.003468.03  
Schmidtea mediterranea mk4.008300.00   Laminin-like protein lam-2
Schmidtea mediterranea mk4.001388.07  
Schmidtea mediterranea mk4.000676.11  
Schmidtea mediterranea mk4.002173.07  
Schmidtea mediterranea mk4.000676.08  
Schmidtea mediterranea mk4.015198.02  
Schmidtea mediterranea mk4.008300.02   Usherin

Essentiality

Bm1_24440 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K08C7.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_K08C7.3 Caenorhabditis elegans larval arrest wormbase
CELE_K08C7.3 Caenorhabditis elegans larval lethal wormbase
CELE_K08C7.3 Caenorhabditis elegans sterile wormbase
CELE_T22A3.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_T22A3.8 Caenorhabditis elegans larval arrest wormbase
CELE_C54D1.5 Caenorhabditis elegans adult lethal wormbase
CELE_C54D1.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C54D1.5 Caenorhabditis elegans larval lethal wormbase
CELE_C54D1.5 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0028 0.5 0.5
0.0023 0.5 0.5
0.0054 0.5 0.5
0.0025 0.3891 0.3891
0.0029 1 1
0.0345 0.4313 0.7962
0.0115 0.3005 0.6968
0.0026 0.435 0.4349
0.0025 0.5 0.5
0.0277 0.3252 0.6005
0.0027 1 1
0.0046 0.3702 0.3702
0.0078 0.3631 0.3631
0.0028 0.5 0.5
0.0077 1 1
0.00203233 1 1
0.0026 1 1
0.0277 0.3252 0.6005
0.0025 1 1
0.0049 0.2501 0.2478
0.0029 1 1
0.0051 1 1
0.0078 0.3631 0.3631
0.0027 0.4212 0.421
0.0218 0.3656 0.4267
0.0027 0.4212 0.421
0.0218 0.3656 0.4267
0.0024 0.5 0.5
0.0173 0.4278 0.6187
0.0078 0.3631 0.3631

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_24440 (Brugia malayi), laminin alpha chain
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