Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.472 | 0.4629 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0062 | 0.0527 | 0.0363 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0062 | 0.0527 | 0.0363 |
Echinococcus granulosus | geminin | 0.0183 | 0.2416 | 0.2285 |
Trypanosoma brucei | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0062 | 0.0527 | 0.0527 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0669 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0669 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0334 | 0.0167 |
Brugia malayi | hypothetical protein | 0.0318 | 0.4529 | 0.4526 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0669 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0263 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.017 | 0.0164 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0345 | 0.4946 | 0.4858 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0062 | 0.0527 | 0.0363 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.2416 | 0.2285 |
Brugia malayi | bHLH-PAS transcription factor | 0.0039 | 0.017 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.2311 | 0.2307 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0062 | 0.0527 | 0.0521 |
Brugia malayi | PAS domain containing protein | 0.0052 | 0.0383 | 0.0378 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0334 | 0.0329 |
Brugia malayi | hypoxia-induced factor 1 | 0.0162 | 0.2098 | 0.2094 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0334 | 0.0167 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0345 | 0.4946 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0669 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0669 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0318 | 0.4529 | 0.4225 |
Echinococcus multilocularis | thymidylate synthase | 0.0669 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0345 | 0.4946 | 0.4858 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0345 | 0.4946 | 0.0762 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0334 | 0.0329 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0345 | 0.4946 | 0.4665 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0334 | 0.0167 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0334 | 0.0167 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0334 | 0.0167 |
Mycobacterium ulcerans | thymidylate synthase | 0.0669 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0263 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0669 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | orotidine-5'-phosphate decarboxylase | 0.0621 | 0.9246 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0052 | 0.0383 | 0.0217 |
Echinococcus multilocularis | geminin | 0.0183 | 0.2416 | 0.2285 |
Loa Loa (eye worm) | camk/mapkapk/mnk protein kinase | 0.0412 | 0.599 | 0.5988 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0345 | 0.4946 | 0.4665 |
Trypanosoma brucei | RNA helicase, putative | 0.0331 | 0.472 | 0.472 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0062 | 0.0527 | 0.0521 |
Onchocerca volvulus | 0.0669 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.2416 | 0.2285 |
Brugia malayi | Protein kinase domain containing protein | 0.0412 | 0.599 | 0.5988 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0669 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0176 | 0.2311 | 0.2307 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0318 | 0.4529 | 0.5 |
Schistosoma mansoni | single-minded | 0.0052 | 0.0383 | 0.0217 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0263 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0263 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0334 | 0.0167 |
Onchocerca volvulus | 0.0559 | 0.8284 | 0.8254 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0669 | 1 | 1 |
Mycobacterium ulcerans | orotidine 5'-phosphate decarboxylase | 0.0062 | 0.0527 | 0.0363 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0345 | 0.4946 | 0.4858 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0669 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0669 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0334 | 0.0167 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0045 | 0.0263 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0162 | 0.2098 | 0.2094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | > 1000 uM kg-1 | Inhibition of rat passive cutaneous anaphylaxis(PCA) reaction was determined after oral administration | ChEMBL. | 6183427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.