Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1049 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.022 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0734 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0734 | 0.0734 |
Echinococcus granulosus | carboxylesterase 5A | 0.022 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0734 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0037 | 0.0734 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0037 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.2445 | 0.2445 |
Schistosoma mansoni | gliotactin | 0.0037 | 0.0734 | 0.0734 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1049 | 0.1049 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Onchocerca volvulus | 0.0037 | 0.0734 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.022 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1049 | 0.1049 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.2445 | 0.2445 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1049 | 0.1049 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0.0734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | carboxylesterase | 0.022 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1049 | 0.1049 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0037 | 0.0734 | 0.0734 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0037 | 0.0734 | 0.0734 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1049 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1049 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.022 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.022 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 0.2445 | 0.2445 |
Schistosoma mansoni | acetylcholinesterase | 0.0037 | 0.0734 | 0.0734 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.2445 | 0.2445 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0037 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Echinococcus granulosus | acetylcholinesterase | 0.022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0037 | 0.0734 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0734 | 0.0734 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1049 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.2445 | 0.2445 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.2445 | 0.2445 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0734 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0037 | 0.0734 | 0.0734 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0037 | 0.0734 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.2445 | 0.2445 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0734 | 0.0734 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.022 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Echinococcus multilocularis | acetylcholinesterase | 0.022 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.2445 | 0.2445 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0037 | 0.0734 | 0.0734 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.2445 | 0.2445 |
Echinococcus granulosus | neuroligin | 0.0037 | 0.0734 | 0.0734 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0037 | 0.0734 | 0.0734 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0037 | 0.0734 | 0.0734 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.2445 | 0.2445 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1049 | 0.1049 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0037 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0037 | 0.0734 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0037 | 0.0734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0734 | 0.0734 |
Onchocerca volvulus | 0.0037 | 0.0734 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.2995 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.