Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4949 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0043 | 0.2588 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0009 | 0.0267 | 0.054 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0009 | 0.0267 | 0.054 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4949 | 0.4949 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0475 | 0.096 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0043 | 0.2588 | 0.5 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0462 | 0.0933 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0043 | 0.2588 | 0.523 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0043 | 0.2588 | 0.523 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0043 | 0.2588 | 0.523 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0043 | 0.2588 | 0.523 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2557 | 0.2557 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0043 | 0.2588 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4949 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0043 | 0.2588 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0043 | 0.2588 | 0.5 |
Onchocerca volvulus | 0.0136 | 0.9096 | 0.9763 | |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0043 | 0.2588 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0043 | 0.2588 | 0.2588 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4949 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0043 | 0.2588 | 0.523 |
Echinococcus multilocularis | Immunoglobulin | 0.0009 | 0.0267 | 0.054 |
Echinococcus multilocularis | Immunoglobulin | 0.0009 | 0.0267 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0638 | 0.0638 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0043 | 0.2588 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0043 | 0.2588 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0043 | 0.2588 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4949 | 0.4949 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0009 | 0.0267 | 0.054 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0043 | 0.2588 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0006 | 0.0032 | 0.0032 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0638 | 0.1289 |
Echinococcus granulosus | defective proboscis extension response | 0.0009 | 0.0267 | 0.054 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0009 | 0.0267 | 0.0267 |
Schistosoma mansoni | nephrin | 0.0012 | 0.043 | 0.0869 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0149 | 1 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0009 | 0.0267 | 0.054 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0638 | 0.1289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4949 | 1 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.043 | 0.0869 |
Brugia malayi | cell division control protein 2 homolog | 0.0043 | 0.2588 | 0.2588 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Echinococcus granulosus | cyclin dependent kinase | 0.0043 | 0.2588 | 0.523 |
Schistosoma mansoni | vesicular amine transporter | 0.0009 | 0.0267 | 0.054 |
Giardia lamblia | Kinase, CMGC CDK | 0.0043 | 0.2588 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0043 | 0.2588 | 0.2588 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4949 | 0.4949 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0043 | 0.2588 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0043 | 0.2588 | 0.523 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0638 | 0.0638 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0043 | 0.2588 | 0.523 |
Plasmodium vivax | protein kinase Crk2 | 0.0043 | 0.2588 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0043 | 0.2588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Giardia lamblia | Kinase, CMGC CDK | 0.0043 | 0.2588 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0139 | 0.9317 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4949 | 0.4949 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4949 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0043 | 0.2588 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.043 | 0.0869 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0043 | 0.2588 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0009 | 0.0267 | 0.0267 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0267 | 0.0267 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0043 | 0.2588 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0475 | 0.0475 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4949 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0043 | 0.2588 | 0.2588 |
Schistosoma mansoni | tyrosine kinase | 0.0006 | 0.0058 | 0.0117 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0043 | 0.2588 | 0.2588 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0043 | 0.2588 | 0.523 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.0475 | 0.096 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4949 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0043 | 0.2588 | 0.523 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.