Detailed information for compound 14452

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.441 | Formula: C25H20F3N3O
  • H donors: 0 H acceptors: 1 LogP: 5.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(cccc1c1ccc(cc1)C(F)(F)F)C(c1ccccc1)CN1C=CC=CC=N1
  • InChi: 1S/C25H20F3N3O/c26-25(27,28)21-13-11-19(12-14-21)22-10-7-17-31(24(22)32)23(20-8-3-1-4-9-20)18-30-16-6-2-5-15-29-30/h1-17,23H,18H2
  • InChiKey: YITOFYWWKAQJCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.0121
Trypanosoma cruzi Peptide deformylase 2, putative 0.0458 0.1798 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.1199 0.5198 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Onchocerca volvulus Matrilysin homolog 0.142 0.621 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0137 0.033 0.1833
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.033 0.5
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0085 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0141 0.0344 0.0353
Loa Loa (eye worm) hypothetical protein 0.0137 0.0329 0.0329
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.033 0.1833
Echinococcus multilocularis adam 17 protease 0.018 0.0525 0.0525
Toxoplasma gondii hypothetical protein 0.1199 0.5198 1
Trypanosoma brucei acetyl-CoA carboxylase 0.0172 0.0488 0.2715
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0186 0.0552 0.073
Onchocerca volvulus 0.064 0.2635 0.4128
Plasmodium falciparum phosphodiesterase delta, putative 0.0137 0.033 0.0121
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1129 0.4875 0.4875
Brugia malayi Matrixin family protein 0.064 0.2635 0.4018
Leishmania major cAMP-specific phosphodiesterase, putative 0.0137 0.033 0.1833
Loa Loa (eye worm) peptidase family M13 containing protein 0.0137 0.0329 0.0329
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0137 0.033 0.1833
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0137 0.033 0.1833
Loa Loa (eye worm) hypothetical protein 0.0137 0.033 0.033
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0085 0.009 0.0184
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0094 0.013 0.0266
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0137 0.033 0.1833
Loa Loa (eye worm) hypothetical protein 0.064 0.2635 0.3987
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Loa Loa (eye worm) hypothetical protein 0.0137 0.0329 0.0329
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0166 0.046 0.0537
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0991 0.4245 0.4245
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.0121
Brugia malayi Peptidase family M13 containing protein 0.0186 0.0552 0.073
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.033 0.1833
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.033 0.1833
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0137 0.033 0.0121
Trypanosoma cruzi Peptide deformylase 2, putative 0.0458 0.1798 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0137 0.033 0.033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0186 0.0552 0.1062
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0113 0.0218 0.0218
Echinococcus multilocularis endothelin converting enzyme 1 0.0186 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.1129 0.4875 0.754
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0137 0.033 0.5
Trypanosoma cruzi acetyl-CoA carboxylase 0.0106 0.0188 0.1045
Loa Loa (eye worm) matrix metalloproteinase 0.064 0.2635 0.3987
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.033 0.1833
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0137 0.033 0.1833
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0308 0.1113 0.2284
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0137 0.033 0.033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0991 0.4245 0.4245
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0137 0.033 0.0121
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1129 0.4875 0.4875
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.0121
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0137 0.033 0.1833
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Brugia malayi Carboxyl transferase domain containing protein 0.0166 0.046 0.0585
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Loa Loa (eye worm) hypothetical protein 0.0186 0.0552 0.0682
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0137 0.033 0.5
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1129 0.4875 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0329 0.0329
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Schistosoma mansoni hypothetical protein 0.0827 0.349 0.7159
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0607 0.2482 0.3744
Trypanosoma brucei Peptide deformylase 2 0.0458 0.1798 1
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.033 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1129 0.4875 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.0121
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus granulosus endothelin converting enzyme 1 0.0186 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.078 0.3275 0.5002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1129 0.4875 0.9378
Loa Loa (eye worm) hypothetical protein 0.064 0.2635 0.3987
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0172 0.0488 0.0488
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0137 0.033 0.0676
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0085 0.009 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Brugia malayi Angiotensin-converting enzyme family protein 0.0607 0.2482 0.3776
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0137 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0378 0.1434 0.2082
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0137 0.033 0.1833
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0094 0.013 0.0266
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Loa Loa (eye worm) hypothetical protein 0.0141 0.0344 0.0353
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.078 0.3275 0.5027
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.0121
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0137 0.033 0.1833
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0137 0.033 0.1833
Loa Loa (eye worm) PDE1B protein 0.0137 0.033 0.033
Plasmodium falciparum peptide deformylase 0.1199 0.5198 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0137 0.033 0.033
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0137 0.033 0.0379
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0137 0.033 0.0379
Mycobacterium ulcerans hydrolase 0.078 0.3275 0.63
Trypanosoma brucei hypothetical protein, conserved 0.0137 0.033 0.1833
Loa Loa (eye worm) matrixin family protein 0.142 0.621 0.9659
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1129 0.4875 0.4875
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0094 0.013 0.0266
Leishmania major hypothetical protein, conserved 0.0137 0.033 0.1833
Leishmania major acetyl-CoA carboxylase, putative 0.0172 0.0488 0.2715
Mycobacterium leprae PROBABLE HYDROLASE 0.078 0.3275 0.63
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0458 0.1798 1
Plasmodium vivax peptide deformylase, putative 0.1199 0.5198 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0344 0.0353
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0137 0.033 0.0676
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.1833
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0137 0.033 0.1833
Brugia malayi Matrixin family protein 0.064 0.2635 0.4018
Brugia malayi Matrixin family protein 0.064 0.2635 0.4018
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.064 0.2635 0.5406
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Loa Loa (eye worm) hypothetical protein 0.0137 0.0329 0.0329
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0137 0.033 0.033
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.1199 0.5198 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Loa Loa (eye worm) hypothetical protein 0.0141 0.0344 0.0353
Mycobacterium ulcerans zinc metalloprotease 0.0186 0.0552 0.1062
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0137 0.033 0.0379
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0113 0.0218 0.0218
Leishmania major polypeptide deformylase-like protein, putative 0.0458 0.1798 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.033 0.033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Loa Loa (eye worm) matrixin family protein 0.1467 0.6425 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.142 0.621 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0552 0.0682
Chlamydia trachomatis peptide deformylase 0.1199 0.5198 0.5
Onchocerca volvulus Matrilysin homolog 0.064 0.2635 0.4128
Brugia malayi Matrixin family protein 0.064 0.2635 0.4018
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0172 0.0488 0.0488
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0137 0.033 0.1833
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.018 0.0525 0.1077
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0137 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0141 0.0344 0.0353
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0137 0.033 0.0676
Loa Loa (eye worm) hypothetical protein 0.0186 0.0552 0.0682
Brugia malayi Matrixin family protein 0.1467 0.6425 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Leishmania major hypothetical protein, conserved 0.0137 0.033 0.1833
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0137 0.033 0.0379
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.033 0.1833
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0137 0.033 0.033
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0137 0.033 0.1833
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0137 0.033 0.0379
Loa Loa (eye worm) hypothetical protein 0.0141 0.0344 0.0353
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0137 0.033 0.033
Schistosoma mansoni acetyl-CoA carboxylase 0.0172 0.0488 0.1001
Brugia malayi Hemopexin family protein 0.0827 0.349 0.5367
Loa Loa (eye worm) hypothetical protein 0.064 0.2635 0.3987
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0991 0.4245 0.6541
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 0.2605 0.2605
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Toxoplasma gondii peptidase family M13 protein 0.0186 0.0552 0.1062
Plasmodium falciparum phosphodiesterase gamma, putative 0.0137 0.033 0.0121
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.078 0.3275 0.63
Mycobacterium leprae probable zinc metalloprotease 0.0186 0.0552 0.1062
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0186 0.0552 0.1132
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.2246 1 1
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0172 0.0488 0.0939
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0137 0.033 0.033
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0458 0.1798 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0137 0.033 0.033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0137 0.033 0.033
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0137 0.033 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.033 0.5
Schistosoma mansoni neprilysin-2 (M13 family) 0.0094 0.013 0.0266
Plasmodium vivax phosphodiesterase gamma, putative 0.0137 0.033 0.0121
Echinococcus granulosus tm gpcr rhodopsin 0.0634 0.2605 0.2605
Treponema pallidum polypeptide deformylase (def) 0.1199 0.5198 0.5
Mycobacterium ulcerans peptide deformylase 0.1199 0.5198 1
Onchocerca volvulus 0.0827 0.349 0.5532
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0094 0.013 0.0266
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.1833
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1129 0.4875 0.4875
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0137 0.033 0.5
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.1199 0.5198 1
Trypanosoma brucei Polypeptide deformylase 1 0.0458 0.1798 1
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.033 0.1833
Echinococcus granulosus adam 17 protease 0.0198 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0137 0.033 0.033
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0137 0.033 0.0379
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0137 0.033 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0991 0.4245 0.6558
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0137 0.033 0.033
Loa Loa (eye worm) peptidase family M13 containing protein 0.0137 0.0329 0.0329
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0172 0.0488 0.0939
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0137 0.033 0.0676
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0137 0.033 0.1833
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0137 0.033 0.0634

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1400 nM Inhibition of [125I]-(D-Pro10)-Dynorphin A binding to human kappa opioid receptor from membranes of HEK293 cells ChEMBL. 12643930
IC50 (binding) = 1400 nM Inhibition of [125I]-(D-Pro10)-Dynorphin A binding to human kappa opioid receptor from membranes of HEK293 cells ChEMBL. 12643930
IC50 (binding) > 10000 nM Inhibition of [125I]-Deltorphin binding to human delta opioid receptor from membranes of HEK293 cells ChEMBL. 12643930
IC50 (binding) > 10000 nM Inhibition of [125I]-Enkephalin binding to human mu opioid receptor from membranes of HEK293 cells ChEMBL. 12643930
IC50 (binding) > 10000 nM Inhibition of [125I]-Deltorphin binding to human delta opioid receptor from membranes of HEK293 cells ChEMBL. 12643930
IC50 (binding) > 10000 nM Inhibition of [125I]-Enkephalin binding to human mu opioid receptor from membranes of HEK293 cells ChEMBL. 12643930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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