Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fatty acid desaturase | 0.0092 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0348 | 0.7358 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.044 | 1 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0092 | 0 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0092 | 0 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0092 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0348 | 0.7358 | 0.7358 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.5346 | 1 |
Onchocerca volvulus | 0.044 | 1 | 1 | |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0092 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.044 | 1 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0348 | 0.7358 | 1 |
Onchocerca volvulus | 0.044 | 1 | 1 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0348 | 0.7358 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.044 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0348 | 0.7358 | 0.7358 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0092 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0348 | 0.7358 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0092 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0092 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8356 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.