Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0354 | 0.9777 | 0.9777 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0504 | 0.0504 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0252 | 0.6791 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0386 | 0.0386 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0134 | 0.3334 | 0.3334 |
Echinococcus multilocularis | muscleblind protein | 0.0162 | 0.4156 | 0.4156 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0575 | 0.0621 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0098 | 0.2262 | 0.2262 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0134 | 0.3334 | 0.3334 |
Echinococcus granulosus | tumor protein p63 | 0.0354 | 0.9777 | 0.9777 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.1702 | 0.2321 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1169 | 0.1682 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1571 | 0.2276 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0386 | 0.0386 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0098 | 0.2262 | 0.2262 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0386 | 0.0522 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0504 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0386 | 0.0386 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1232 | 0.1232 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0093 | 0.2137 | 0.2137 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.2518 | 0.3677 |
Echinococcus multilocularis | geminin | 0.0361 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.1531 | 0.2062 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0128 | 0.3142 | 0.3142 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0386 | 0.0386 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.065 | 0.0914 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0162 | 0.4156 | 0.4156 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0098 | 0.2262 | 0.2262 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3334 | 0.4885 |
Brugia malayi | Pax transcription factor protein 2 | 0.0252 | 0.6791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.2518 | 0.3677 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.3334 | 0.3334 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0577 | 0.0806 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0504 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0098 | 0.2262 | 0.3166 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0709 | 0.1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0386 | 0.0334 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0504 | 0.0504 |
Onchocerca volvulus | 0.0252 | 0.6791 | 1 | |
Echinococcus granulosus | muscleblind protein | 0.0162 | 0.4156 | 0.4156 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0386 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1372 | 0.1981 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0502 | 0.0502 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0504 | 0.0504 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0386 | 0.0386 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0386 | 0.0386 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0134 | 0.3334 | 0.3334 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0918 | 0.0918 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0386 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.131 |
Leishmania major | ion transport protein-like protein | 0.0114 | 0.273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.4156 | 0.6101 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1531 | 0.2217 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0504 | 0.5 |
Trypanosoma cruzi | ion transport protein, putative | 0.0114 | 0.273 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.1342 | 0.1342 |
Trypanosoma cruzi | ion transport protein, putative | 0.0114 | 0.273 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0091 | 0.0091 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.2518 | 0.3551 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0386 | 0.0386 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0504 | 0.0513 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1531 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2262 | 0.3299 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1232 | 0.1232 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0386 | 0.0386 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0386 | 0.0522 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0504 | 0.0504 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0091 | 0.0091 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0386 | 0.0334 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.2262 | 0.2262 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.2518 | 0.3551 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.4156 | 0.6101 |
Brugia malayi | Muscleblind-like protein | 0.0162 | 0.4156 | 0.6024 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0504 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0098 | 0.2262 | 0.2262 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.