Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | gliotactin | 0.0073 | 0.1228 | 0.1228 |
Echinococcus multilocularis | neuroligin | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | alkaline phosphatase | 0.0157 | 0.3288 | 0.3288 |
Brugia malayi | Carboxylesterase family protein | 0.0431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Onchocerca volvulus | 0.0073 | 0.1228 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0357 | 0.0357 |
Loa Loa (eye worm) | carboxylesterase | 0.0073 | 0.1228 | 0.1228 |
Echinococcus granulosus | neuroligin | 0.0073 | 0.1228 | 0.1228 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0431 | 1 | 1 |
Onchocerca volvulus | 0.0073 | 0.1228 | 0.5 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0073 | 0.1228 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0073 | 0.1228 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0073 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0779 | 0.0779 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0779 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0431 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0073 | 0.1228 | 0.1228 |
Onchocerca volvulus | 0.0073 | 0.1228 | 0.5 | |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0157 | 0.3288 | 0.3288 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0073 | 0.1228 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0157 | 0.3288 | 0.3288 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0157 | 0.3288 | 0.3288 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0073 | 0.1228 | 0.1228 |
Onchocerca volvulus | 0.0073 | 0.1228 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0073 | 0.1228 | 0.1228 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0157 | 0.3288 | 0.3288 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0357 | 0.0357 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | carboxylesterase | 0.0431 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Echinococcus granulosus | acetylcholinesterase | 0.0431 | 1 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0157 | 0.3288 | 0.3288 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1442 | 0.1442 |
Echinococcus multilocularis | acetylcholinesterase | 0.0431 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0073 | 0.1228 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | alkaline phosphatase | 0.0157 | 0.3288 | 0.3288 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0157 | 0.3288 | 0.3288 |
Onchocerca volvulus | 0.0073 | 0.1228 | 0.5 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0073 | 0.1228 | 0.1228 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0073 | 0.1228 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0779 | 0.0779 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0157 | 0.3288 | 0.3288 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1228 | 0.1228 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.1228 | 0.1228 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.1228 | 0.1228 |
Echinococcus multilocularis | acetylcholinesterase | 0.0431 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0073 | 0.1228 | 0.1228 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0431 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0073 | 0.1228 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0779 | 0.0779 |
Echinococcus granulosus | alkaline phosphatase | 0.0157 | 0.3288 | 0.3288 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0357 | 0.0357 |
Brugia malayi | Carboxylesterase family protein | 0.0073 | 0.1228 | 0.1228 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0355 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.