Detailed information for compound 1449967

Basic information

Technical information
  • TDR Targets ID: 1449967
  • Name: N-[5-oxo-6-(trifluoromethyl)-2,3-dihydroimida zo[2,1-b][1,3]thiazol-6-yl]pyridine-3-carboxa mide
  • MW: 330.286 | Formula: C12H9F3N4O2S
  • H donors: 1 H acceptors: 3 LogP: 1.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N2CCSC2=NC1(NC(=O)c1cccnc1)C(F)(F)F
  • InChi: 1S/C12H9F3N4O2S/c13-12(14,15)11(9(21)19-4-5-22-10(19)18-11)17-8(20)7-2-1-3-16-6-7/h1-3,6H,4-5H2,(H,17,20)
  • InChiKey: MVRJMXGHRGBKHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-oxo-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-6-yl]pyridine-3-carboxamide
  • N-[5-oxo-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-6-yl]-3-pyridinecarboxamide
  • N-[5-keto-6-(trifluoromethyl)-2,3-dihydroimidazo[2,1-b]thiazol-6-yl]nicotinamide
  • MLS000756170
  • N-[5-oxo-6-(trifluoromethyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazol-6-yl]nicotinamide
  • SMR000225884
  • Nicotinamide, N-(5-oxo-6-trifluoromethyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazol-6-yl)-
  • A2993/0126103

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0064 0.0007
Echinococcus multilocularis receptor type guanylyl cyclase 0.0141 0.0702 0.0649
Brugia malayi hypothetical protein 0.0141 0.0702 0.0801
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0057 1
Echinococcus granulosus hypothetical protein 0.0824 0.4437 0.4405
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0064 0.0007
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0384 0.2029 0.2029
Echinococcus multilocularis glutamate receptor 2 0.0141 0.0702 0.0649
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0064 0.0104
Toxoplasma gondii exonuclease III APE 0.0023 0.0057 0.8958
Echinococcus granulosus receptor type guanylyl cyclase 0.0141 0.0702 0.0649
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0064 0.0913
Echinococcus granulosus atrial natriuretic peptide receptor 0.0141 0.0702 0.0649
Echinococcus granulosus geminin 0.0205 0.1051 0.1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.1254 0.6783 0.6765
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0064
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0064 0.0008
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Schistosoma mansoni tyrosine kinase 0.0141 0.0702 0.0761
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0064 0.0064
Echinococcus granulosus bloom syndrome protein 0.0024 0.0064 0.0007
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0141 0.0702 0.0702
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0064 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0064 1
Loa Loa (eye worm) glutamate receptor 0.1497 0.811 0.811
Echinococcus granulosus glutamate receptor 2 0.0141 0.0702 0.0649
Echinococcus granulosus tyrosine kinase 0.0141 0.0702 0.0649
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0064 0.0007
Schistosoma mansoni hypothetical protein 0.0205 0.1051 0.1139
Loa Loa (eye worm) hypothetical protein 0.1843 1 1
Schistosoma mansoni metabotropic glutamate receptor 0.073 0.3919 0.4245
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0057 1
Entamoeba histolytica hypothetical protein 0.0141 0.0702 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.1497 0.811 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0141 0.0702 0.0649
Schistosoma mansoni hypothetical protein 0.0205 0.1051 0.1139
Loa Loa (eye worm) RGC/RGC protein kinase 0.0141 0.0702 0.0702
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0141 0.0702 0.0649
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0057 0.5
Loa Loa (eye worm) hypothetical protein 0.0384 0.2029 0.2029
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0064 1
Brugia malayi Receptor family ligand binding region containing protein 0.0141 0.0702 0.0801
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0064 1
Schistosoma mansoni ap endonuclease 0.0023 0.0057 0.0062
Schistosoma mansoni tyrosine kinase 0.0141 0.0702 0.0761
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0064 0.0007
Brugia malayi Guanylyl cyclase protein 23 0.0141 0.0702 0.0801
Echinococcus granulosus glutamate receptor 2 0.0141 0.0702 0.0649
Loa Loa (eye worm) glutamate receptor 0.0589 0.315 0.315
Echinococcus granulosus nmda type glutamate receptor 0.0141 0.0702 0.0649
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0064 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0064 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0064 1
Echinococcus multilocularis tyrosine kinase 0.0141 0.0702 0.0649
Loa Loa (eye worm) hypothetical protein 0.0243 0.1261 0.1261
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1843 1 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0141 0.0702 0.0801
Schistosoma mansoni ap endonuclease 0.0023 0.0057 0.0062
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.1356 0.7342 0.9045
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0141 0.0702 0.0649
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Loa Loa (eye worm) RGC/RGC protein kinase 0.0141 0.0702 0.0702
Schistosoma mansoni glutamate receptor NMDA 0.0141 0.0702 0.0761
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0057 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0141 0.0702 0.0649
Leishmania major extracellular receptor, putative 0.0141 0.0702 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0141 0.0702 0.0649
Echinococcus multilocularis geminin 0.0205 0.1051 0.1
Brugia malayi metabotropic glutamate receptor type 2 0.073 0.3919 0.4795
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0064 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0057 0.0818
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Echinococcus multilocularis glutamate receptor 2 0.0141 0.0702 0.0649
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0384 0.2029 0.2029
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0141 0.0702 0.0649
Loa Loa (eye worm) RecQ helicase 0.0024 0.0064 0.0064
Echinococcus granulosus metabotropic glutamate receptor 2 0.1254 0.6783 0.6765
Loa Loa (eye worm) RGC/RGC protein kinase 0.0141 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0141 0.0702 0.0702
Schistosoma mansoni protein kinase 0.0141 0.0702 0.0761
Echinococcus multilocularis GPCR, family 3, C terminal 0.0243 0.1261 0.121
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.1702 0.9231 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0243 0.1261 0.1494
Schistosoma mansoni hypothetical protein 0.0243 0.1261 0.1366
Echinococcus multilocularis conserved hypothetical protein 0.0822 0.4422 0.439
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0064 0.0104
Brugia malayi Receptor family ligand binding region containing protein 0.0384 0.2029 0.2449
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0141 0.0702 0.0649
Schistosoma mansoni metabotropic glutamate receptor 0.1254 0.6783 0.7348
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0141 0.0702 0.0649
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0064 0.0008
Trypanosoma cruzi extracellular receptor, putative 0.0141 0.0702 1
Schistosoma mansoni DNA helicase recq5 0.0024 0.0064 0.0069
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0057 0.0057
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0064 0.0008
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0243 0.1261 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0064 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0057 0.5
Echinococcus multilocularis nmda type glutamate receptor 0.0141 0.0702 0.0649
Onchocerca volvulus Poor gastrulation protein homolog 0.0243 0.1261 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0141 0.0702 0.0649
Schistosoma mansoni DNA helicase recq1 0.0024 0.0064 0.0069
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0064 1
Echinococcus granulosus GPCR family 3 C terminal 0.0243 0.1261 0.121

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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