Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | regulator of G-protein signaling 4 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proliferating cell nuclear antigen | 0.0136 | 0.265 | 1 |
Echinococcus multilocularis | expressed protein | 0.0451 | 1 | 1 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.0136 | 0.265 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0421 | 0.1589 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.4428 |
Plasmodium vivax | proliferating cell nuclear antigen, putative | 0.0136 | 0.265 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1173 | 0.1173 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0866 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0421 | 0.1589 |
Giardia lamblia | PcnA | 0.0136 | 0.265 | 0.5 |
Echinococcus granulosus | proliferating cell nuclear antigen | 0.0136 | 0.265 | 0.265 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0866 | 0.327 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.0136 | 0.265 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.5 |
Toxoplasma gondii | proliferating cell nuclear antigen PCNA1 | 0.0136 | 0.265 | 1 |
Trypanosoma brucei | proliferative cell nuclear antigen (PCNA), putative | 0.0136 | 0.265 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0421 | 0.1589 |
Leishmania major | proliferative cell nuclear antigen (PCNA), putative | 0.0136 | 0.265 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.4428 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.0136 | 0.265 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.0053 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0866 | 0.327 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0866 | 0.327 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.0136 | 0.265 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1173 | 0.1173 |
Plasmodium falciparum | proliferating cell nuclear antigen 1 | 0.0136 | 0.265 | 1 |
Echinococcus multilocularis | proliferating cell nuclear antigen | 0.0136 | 0.265 | 0.265 |
Loa Loa (eye worm) | proliferating cell nuclear antigen | 0.0136 | 0.265 | 1 |
Brugia malayi | proliferating cell nuclear antigen (PCNA) | 0.0136 | 0.265 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1173 | 0.5 |
Entamoeba histolytica | proliferating cell nuclear antigen, putative | 0.0136 | 0.265 | 1 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.0136 | 0.265 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0631 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.2239 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.