Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0899 | 0.5836 | 0.5836 |
Schistosoma mansoni | protein kinase | 0.1534 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1534 | 1 | 1 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0464 | 0.2991 | 0.2995 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.0122 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0464 | 0.2991 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0122 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0122 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0078 | 0.6421 |
Loa Loa (eye worm) | hypothetical protein | 0.1532 | 0.9985 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0078 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0078 | 0.6421 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.0122 |
Schistosoma mansoni | protein kinase | 0.1534 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0122 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0078 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0122 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0078 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0122 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0122 | 0.0122 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0122 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1534 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.2976 | 0.298 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0122 | 0.0122 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0122 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0464 | 0.2991 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0122 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0122 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0122 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0122 | 0.0122 |
Onchocerca volvulus | 0.0026 | 0.0122 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.0122 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0122 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Toxoplasma gondii | propionate-CoA ligase | 0.0008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.