Detailed information for compound 1456177

Basic information

Technical information
  • TDR Targets ID: 1456177
  • Name: 2-ethyl-3-(2-methoxyethyl)chromeno[3,2-e]pyri midine-4,5-dione
  • MW: 300.309 | Formula: C16H16N2O4
  • H donors: 0 H acceptors: 2 LogP: 1.24 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(CC)nc2c(c1=O)c(=O)c1c(o2)cccc1
  • InChi: 1S/C16H16N2O4/c1-3-12-17-15-13(16(20)18(12)8-9-21-2)14(19)10-6-4-5-7-11(10)22-15/h4-7H,3,8-9H2,1-2H3
  • InChiKey: JXASXKLTLWFIND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-ethyl-3-(2-methoxyethyl)chromeno[3,2-e]pyrimidine-4,5-quinone
  • SMR000047558
  • ZINC02206599
  • MLS000083903

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Plasmodium vivax glutathione reductase, putative 0.0046 0.1216 0.2862
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1216 0.2781
Leishmania major trypanothione reductase 0.0046 0.1216 0.2781
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1239 0.2834
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0087 0.0198
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0087 0.0172
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.4374 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Loa Loa (eye worm) glutathione reductase 0.0046 0.1216 0.1977
Loa Loa (eye worm) hypothetical protein 0.0176 0.6151 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0 0.5
Plasmodium falciparum glutathione reductase 0.0046 0.1216 0.2862
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0056 0.1624 0.3712
Mycobacterium tuberculosis Probable peptidase 0.0051 0.1431 0.1356
Brugia malayi hypothetical protein 0.0126 0.425 0.6909
Loa Loa (eye worm) hypothetical protein 0.0126 0.425 0.6909
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0087 0.0204
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1216 0.114
Plasmodium falciparum thioredoxin reductase 0.0046 0.1216 0.2862
Trypanosoma brucei oligopeptidase b 0.0051 0.1431 0.3271
Toxoplasma gondii LsmAD domain-containing protein 0.0126 0.425 0.9717
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.425 0.9717
Trypanosoma cruzi oligopeptidase b 0.0051 0.1431 0.3271
Trypanosoma cruzi oligopeptidase b 0.0051 0.1431 0.3271
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1133 0.2666
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1133 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0087 0.0204
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.3431 0.8393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1133 0.1842
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1133 0.1842
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0087 0.0198
Mycobacterium tuberculosis Probable reductase 0.0104 0.3431 0.3374
Mycobacterium tuberculosis Conserved protein 0.0043 0.1133 0.1056
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1133 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0087 0.0198
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0087 0.0198
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0087 0.0765
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0087 0.5
Brugia malayi beta-lactamase family protein 0.0043 0.1133 0.1842
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.4374 1
Plasmodium vivax ataxin-2 like protein, putative 0.0126 0.425 1
Brugia malayi N-terminal motif family protein 0.0176 0.6151 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.4374 0.8705
Toxoplasma gondii prolyl endopeptidase 0.0129 0.4374 1
Trypanosoma brucei trypanothione reductase 0.0046 0.1216 0.2781
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1216 0.2862
Mycobacterium ulcerans lipase LipD 0.0043 0.1133 0.7786
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.3431 0.3374
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.3431 0.3374
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.425 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.1133 0.7786
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.6151 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.1431 0.3271
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.1431 0.1356
Loa Loa (eye worm) hypothetical protein 0.0129 0.4374 0.711
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.3431 0.3374
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1133 0.7786
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1239 0.2834
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1133 0.2591
Plasmodium falciparum glutathione reductase 0.0016 0.0087 0.0204
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.4374 0.711
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.3861 0.3807
Trypanosoma brucei PAB1-binding protein , putative 0.0126 0.425 0.9717
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.425 0.9717
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.1842
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0087 0.0198
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.1431 0.3271
Onchocerca volvulus 0.0043 0.1133 0.1842
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0087 0.0198
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0087 0.0204
Leishmania major oligopeptidase b 0.0051 0.1431 0.3271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.3871 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.1842
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.4374 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0087 0.0198
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1133 0.2591
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.1431 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.1133 0.1056
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1133 0.7786
Entamoeba histolytica hypothetical protein, conserved 0.0014 0 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0056 0.1624 0.3712
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.1133 0.1056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.1842
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.1431 0.3271
Trichomonas vaginalis esterase, putative 0.0043 0.1133 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0087 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.3871 0.3818
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.1133 0.1056
Brugia malayi beta-lactamase 0.0043 0.1133 0.1842
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.4374 0.8705
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0087 0.0198
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1133 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0087 0.0141
Brugia malayi glutathione reductase 0.0046 0.1216 0.1977
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0087 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1133 0.2255
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.1842
Loa Loa (eye worm) beta-lactamase 0.0043 0.1133 0.1842
Trypanosoma brucei prolyl endopeptidase 0.0129 0.4374 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.1842
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1216 0.1977
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.3431 0.3374
Mycobacterium tuberculosis Conserved protein 0.0043 0.1133 0.1056
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.3871 0.3818
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1133 0.2255
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.4374 0.711
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.1133 0.1056
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0087 0.0198
Plasmodium falciparum thioredoxin reductase 0.0016 0.0087 0.0204
Leishmania major hypothetical protein, conserved 0.0126 0.425 0.9717
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1133 0.2591
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.1431 0.3271
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.1133 0.1056
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.3871 0.3818
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0087 0.5
Toxoplasma gondii thioredoxin reductase 0.0046 0.1216 0.2781
Onchocerca volvulus 0.0043 0.1133 0.1842
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1133 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0087 0.0198
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0087 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1133 0.2591
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0087 0.0198
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.1133 0.1056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1133 0.2591
Brugia malayi hypothetical protein 0.0081 0.2562 0.4165
Brugia malayi beta-lactamase family protein 0.0043 0.1133 0.1842
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.1133 0.1056
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0087 0.0198
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.1133 0.1056
Onchocerca volvulus 0.0043 0.1133 0.1842
Schistosoma mansoni hypothetical protein 0.0056 0.1624 0.3232
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0087 0.0204
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.1842
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0087 0.0765
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.3431 0.3374
Leishmania major hypothetical protein, conserved 0.0043 0.1133 0.2591
Treponema pallidum NADH oxidase 0.0016 0.0087 0.5
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.1431 0.1087
Brugia malayi Thioredoxin reductase 0.0046 0.1216 0.1977
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1133 1
Toxoplasma gondii ABC1 family protein 0.0043 0.1133 0.2591
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.425 1
Echinococcus granulosus prolyl endopeptidase 0.0129 0.4374 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.1133 0.7786
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0087 0.0198
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.1431 0.3271

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2239 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.