Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | metacaspase MCA3 | 0.4486 | 0.282 | 0.5 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.4486 | 0.282 | 0.8971 |
Leishmania major | metacaspase, putative | 0.4486 | 0.282 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.0094 | 0.0094 |
Trypanosoma brucei | metacaspase 5, putative | 0.4486 | 0.282 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0026 | 0.0026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4486 | 0.282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4997 | 0.3143 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0511 | 0.0303 | 0.0303 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0026 | 0.0026 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0026 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.4486 | 0.282 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0511 | 0.0303 | 0.0303 |
Trypanosoma cruzi | metacaspase, putative | 0.4486 | 0.282 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.0303 | 0.0964 |
Echinococcus granulosus | caspase 3 | 1.1342 | 0.716 | 0.716 |
Schistosoma mansoni | caspase-3 (C14 family) | 1.5828 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0511 | 0.0303 | 0.0963 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0026 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.4997 | 0.3143 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0026 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.4486 | 0.282 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.4486 | 0.282 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4486 | 0.282 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0 | 0.0001 |
Echinococcus multilocularis | caspase 8 | 0.4486 | 0.282 | 0.2819 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0094 | 0.0299 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.4486 | 0.282 | 0.2819 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0 | 0.0001 |
Plasmodium vivax | metacaspase 1, putative | 0.4486 | 0.282 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.4997 | 0.3143 | 0.3143 |
Trypanosoma cruzi | metacaspase, putative | 0.4486 | 0.282 | 0.5 |
Plasmodium falciparum | metacaspase-like protein | 0.4486 | 0.282 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4486 | 0.282 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.4486 | 0.282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.0094 | 0.0299 |
Brugia malayi | Cell death protein 3 precursor | 0.4997 | 0.3143 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.4486 | 0.282 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4486 | 0.282 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 1.5828 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0026 | 0.0026 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0026 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4486 | 0.282 | 0.5 |
Echinococcus multilocularis | caspase 3 | 1.1342 | 0.716 | 0.716 |
Trypanosoma brucei | metacaspase | 0.4486 | 0.282 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.0094 | 0.0298 |
Echinococcus granulosus | caspase 2 | 0.4997 | 0.3143 | 0.3143 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Onchocerca volvulus | 0.0511 | 0.0303 | 0.0963 | |
Loa Loa (eye worm) | hypothetical protein | 0.4486 | 0.282 | 0.8971 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4486 | 0.282 | 0.5 |
Trypanosoma cruzi | metacaspase 5, putative | 0.4486 | 0.282 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 1.5828 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0026 | 0.0026 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0511 | 0.0303 | 0.0303 |
Trypanosoma brucei | Metacaspase-4 | 0.4486 | 0.282 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.4486 | 0.282 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.4486 | 0.282 | 0.5 |
Trypanosoma brucei | metacaspase MCA2 | 0.4486 | 0.282 | 0.5 |
Echinococcus granulosus | caspase 8 | 0.4486 | 0.282 | 0.2819 |
Echinococcus granulosus | caspase | 1.5828 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.4486 | 0.282 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.0094 | 0.0094 |
Echinococcus multilocularis | caspase 2 | 0.4997 | 0.3143 | 0.3143 |
Echinococcus multilocularis | caspase | 1.5828 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0 | 0.0001 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.4486 | 0.282 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5104 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (binding) | 10 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.