Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Endonuclease G | 0.01 | 0.2216 | 0.5262 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0359 | 1 | 1 |
Schistosoma mansoni | endonuclease related | 0.01 | 0.2216 | 0.2216 |
Schistosoma mansoni | hypothetical protein | 0.0359 | 1 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.01 | 0.2216 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.01 | 0.2216 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.3425 | 0.3425 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0166 | 0.4211 | 0.4211 |
Trypanosoma brucei | endonuclease G, putative | 0.01 | 0.2216 | 1 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.4211 | 0.4211 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.01 | 0.2216 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4211 | 0.4211 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.4211 | 0.4211 |
Mycobacterium leprae | hypothetical protein | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.4211 | 0.4211 |
Echinococcus multilocularis | Endonuclease G | 0.01 | 0.2216 | 0.5262 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.01 | 0.2216 | 0.5 |
Echinococcus granulosus | ectonucleotide | 0.014 | 0.3425 | 0.8134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Onchocerca volvulus | 0.0359 | 1 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.01 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0026 | 0 | 0.5 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.01 | 0.2216 | 1 |
Leishmania major | endonuclease G, putative | 0.01 | 0.2216 | 1 |
Onchocerca volvulus | 0.0166 | 0.4211 | 0.4211 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.014 | 0.3425 | 0.8134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.014 | 0.3425 | 0.8134 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide | 0.014 | 0.3425 | 0.8134 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.01 | 0.2216 | 0.2216 |
Onchocerca volvulus | 0.0166 | 0.4211 | 0.4211 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.4211 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.01 | 0.2216 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.01 | 0.2216 | 0.5 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.9728 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.