Detailed information for compound 1459817

Basic information

Technical information
  • TDR Targets ID: 1459817
  • Name: 4-[(4-chlorophenyl)-[1-(2-methoxyethyl)tetraz ol-5-yl]methyl]thiomorpholine hydrochloride
  • MW: 390.331 | Formula: C15H21Cl2N5OS
  • H donors: 0 H acceptors: 3 LogP: 2.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1nnnc1C(c1ccc(cc1)Cl)N1CCSCC1.Cl
  • InChi: 1S/C15H20ClN5OS.ClH/c1-22-9-6-21-15(17-18-19-21)14(20-7-10-23-11-8-20)12-2-4-13(16)5-3-12;/h2-5,14H,6-11H2,1H3;1H
  • InChiKey: DWLANGJGCDVXBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(4-chlorophenyl)-[1-(2-methoxyethyl)-5-tetrazolyl]methyl]thiomorpholine hydrochloride
  • 4-[(4-chlorophenyl)-[1-(2-methoxyethyl)-1,2,3,4-tetrazol-5-yl]methyl]thiomorpholine hydrochloride
  • 4-{(4-Chloro-phenyl)-[1-(2-methoxy-ethyl)-1H-tetrazol-5-yl]-methyl}-thiomorpholine
  • MLS000033604
  • SMR000003968

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi casein kinase, putative 0.0044 0.0214 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0246 0.1773 0.1759
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0889 0.6719 0.6714
Onchocerca volvulus 0.0246 0.1773 0.1631
Onchocerca volvulus 0.0114 0.0751 0.0592
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0411 0.3043 0.3031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0056 0.5
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0291 0.2117 0.2103
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0411 0.3043 0.4196
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.1773 0.1759
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Echinococcus granulosus epidermal growth factor receptor 0.0065 0.0376 0.0497
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0956 0.7239 0.7234
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus multilocularis casein kinase I alpha 0.0044 0.0214 0.0283
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0411 0.3043 0.419
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0411 0.3043 0.419
Giardia lamblia Kinase, CK1 Casein kinase 0.0044 0.0214 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0137 0.0932 0.1267
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0246 0.1773 0.1759
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Echinococcus multilocularis dna polymerase eta 0.0023 0.0056 0.0064
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Schistosoma mansoni tyrosine kinase 0.0137 0.0932 0.0916
Brugia malayi hypothetical protein 0.0114 0.0751 0.0735
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.1773 0.1759
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.1773 0.1759
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Brugia malayi excitatory GABA receptor EXP-1A 0.0246 0.1773 0.1759
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0114 0.0751 0.1016
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0214 0.0197
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.1773 0.2439
Loa Loa (eye worm) ACC-1 protein 0.0246 0.1773 0.1759
Loa Loa (eye worm) acetylcholine receptor protein 0.0114 0.0751 0.0735
Brugia malayi follicle stimulating hormone receptor 0.028 0.203 0.2016
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0018 0.0017 0.0011
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0114 0.0751 0.0735
Onchocerca volvulus 0.0133 0.0898 0.0741
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0114 0.0751 0.0735
Brugia malayi Protein kinase domain containing protein 0.0078 0.0476 0.046
Echinococcus granulosus nAChR subunit 0.0133 0.0898 0.122
Trypanosoma brucei casein kinase I, isoform 2 0.0044 0.0214 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0133 0.0898 0.0882
Entamoeba histolytica casein kinase 1, putative 0.0044 0.0214 0.1881
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0056 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.1773 0.1759
Onchocerca volvulus 0.1315 1 1
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0246 0.1773 0.1759
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0018 0.0017 0.0011
Schistosoma mansoni tyrosine kinase 0.0065 0.0376 0.0359
Echinococcus multilocularis glycine receptor subunit beta 0.0246 0.1773 0.2439
Onchocerca volvulus 0.1315 1 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0246 0.1773 0.1759
Brugia malayi Cation transporter family protein 0.0246 0.1773 0.1759
Echinococcus multilocularis nAChR subunit 0.0246 0.1773 0.2439
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0246 0.1773 0.1759
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0056 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0133 0.0898 0.0882
Echinococcus granulosus insulin receptor 0.0137 0.0932 0.1267
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0114 0.0751 0.1016
Schistosoma mansoni tyrosine kinase 0.0065 0.0376 0.0359
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0133 0.0898 0.0882
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0246 0.1773 0.2431
Echinococcus multilocularis epidermal growth factor receptor 0.0065 0.0376 0.0507
Loa Loa (eye worm) hypothetical protein 0.1201 0.9125 0.9124
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Loa Loa (eye worm) TK/EGFR protein kinase 0.0065 0.0376 0.0359
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0137 0.0932 0.1276
Echinococcus granulosus microtubule associated protein 2 0.0804 0.6067 0.8378
Echinococcus multilocularis glycine receptor subunit beta 0.0246 0.1773 0.2439
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0133 0.0898 0.0882
Schistosoma mansoni nAChR subunit 0.0114 0.0751 0.0735
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0039
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0114 0.0751 0.0735
Brugia malayi map kinase activated protein kinase protein 2 0.0956 0.7239 0.7234
Echinococcus granulosus dna polymerase eta 0.0023 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.1315 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0114 0.0751 0.0735
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0411 0.3043 0.4196
Schistosoma mansoni DNA polymerase eta 0.0023 0.0056 0.0039
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0114 0.0751 0.1026
Trypanosoma cruzi casein kinase, putative 0.0044 0.0214 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0114 0.0751 0.1026
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Echinococcus granulosus casein kinase I alpha 0.0044 0.0214 0.0273
Loa Loa (eye worm) LGC-31 protein 0.0246 0.1773 0.1759
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Echinococcus multilocularis casein kinase I alpha 0.0044 0.0214 0.0283
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0956 0.7239 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0018 0.0017 0.0011
Echinococcus granulosus tyrosine protein kinase Lyn 0.0024 0.0062 0.0062
Brugia malayi Protein kinase domain containing protein 0.0137 0.0932 0.0916
Toxoplasma gondii casein kinase I 0.0044 0.0214 0.5
Schistosoma mansoni nAChR subunit 0.0114 0.0751 0.0735
Echinococcus granulosus casein kinase I alpha 0.0044 0.0214 0.0273
Onchocerca volvulus 0.0133 0.0898 0.0741
Onchocerca volvulus Putative nachr subunit 0.0411 0.3043 0.2923
Schistosoma mansoni tyrosine kinase 0.0065 0.0376 0.0359
Echinococcus granulosus epidermal growth factor receptor 0.0065 0.0376 0.0497
Brugia malayi hypothetical protein 0.0114 0.0751 0.0735
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0114 0.0751 0.0735
Trypanosoma cruzi casein kinase, putative 0.0044 0.0214 1
Schistosoma mansoni tyrosine kinase 0.0059 0.0332 0.0315
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0056 0.0039
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0056 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.2601
Echinococcus multilocularis nAChR subunit 0.0133 0.0898 0.1229
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.203 0.2016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0017 0.0011
Entamoeba histolytica casein kinase, putative 0.0044 0.0214 0.1881
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0017 0.0011
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0246 0.1773 0.2431
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0114 0.0751 0.0735
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.1773 0.2431
Schistosoma mansoni neurotransmitter gated ion channel 0.0133 0.0898 0.0882
Loa Loa (eye worm) ACC-1 protein 0.0246 0.1773 0.1759
Schistosoma mansoni tyrosine kinase 0.0059 0.0332 0.0315
Echinococcus granulosus dna polymerase kappa 0.0023 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Trypanosoma cruzi casein kinase, putative 0.0044 0.0214 1
Brugia malayi Protein kinase domain containing protein 0.0889 0.6719 0.6714
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0065 0.0376 0.0497
Schistosoma mansoni acetylcholine receptor subunit beta 0.0114 0.0751 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0056 0.0039
Trichomonas vaginalis CK1 family protein kinase 0.0044 0.0214 1
Brugia malayi casein kinase 1, delta 0.0044 0.0214 0.0197
Schistosoma mansoni microtubule-associated protein tau 0.0804 0.6067 0.6061
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.1315 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0018 0.0017 0.0011
Brugia malayi Protein kinase domain containing protein 0.0291 0.2117 0.2103
Plasmodium vivax casein kinase 1, putative 0.0044 0.0214 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.2601
Echinococcus granulosus casein kinase I delta 0.0044 0.0214 0.0273
Echinococcus multilocularis casein kinase I delta 0.0044 0.0214 0.0283
Loa Loa (eye worm) TK/INSR protein kinase 0.0137 0.0932 0.0916
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.1773 0.2431
Echinococcus granulosus glycine receptor subunit beta 0.0246 0.1773 0.2431
Schistosoma mansoni acetylcholine receptor-related 0.0114 0.0751 0.0735
Onchocerca volvulus 0.0114 0.0751 0.0592
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0018 0.0017 0.0011
Brugia malayi Protein kinase domain containing protein 0.0291 0.2117 0.2103
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Echinococcus multilocularis casein kinase I alpha 0.0044 0.0214 0.0283
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0246 0.1773 0.2431
Echinococcus multilocularis insulin receptor 0.0137 0.0932 0.1276
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0246 0.1773 0.1759
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus granulosus casein kinase I alpha 0.0044 0.0214 0.0273
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Loa Loa (eye worm) hypothetical protein 0.0411 0.3043 0.3031
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0056 0.5
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0246 0.1773 0.1759
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Schistosoma mansoni hypothetical protein 0.006 0.034 0.0324
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Schistosoma mansoni tyrosine kinase 0.0059 0.0332 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.1773 0.1759
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0246 0.1773 0.2439
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0246 0.1773 0.1759
Brugia malayi hypothetical protein 0.0114 0.0751 0.0735
Echinococcus multilocularis casein kinase I delta 0.0044 0.0214 0.0283
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.1773 0.1759
Loa Loa (eye worm) GABA receptor subunit 0.0133 0.0898 0.0882
Trypanosoma cruzi casein kinase, putative 0.0044 0.0214 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0246 0.1773 0.2439
Trichomonas vaginalis CK1 family protein kinase 0.0044 0.0214 1
Schistosoma mansoni serine/threonine protein kinase 0.0956 0.7239 0.7234
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0133 0.0898 0.0882
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.0039
Leishmania major casein kinase, putative 0.0044 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0291 0.2117 0.2103
Loa Loa (eye worm) hypothetical protein 0.0291 0.2117 0.2103
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.0053
Echinococcus multilocularis tyrosine protein kinase Abl 0.0018 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0133 0.0898 0.0882
Onchocerca volvulus 0.0044 0.0214 0.0046
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0956 0.7239 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0114 0.0751 0.1026
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0044 0.0214 0.0197
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0114 0.0751 0.0735
Echinococcus granulosus casein kinase I delta 0.0044 0.0214 0.0273
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.1773 0.1759
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0246 0.1773 0.1759
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus granulosus nAChR subunit 0.0246 0.1773 0.2431
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.1773 0.1759
Onchocerca volvulus 0.0246 0.1773 0.1631
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0246 0.1773 0.2439
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0056 0.2601
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0246 0.1773 0.2431
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0056 0.0064
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Echinococcus multilocularis microtubule associated protein 2 0.0804 0.6067 0.838
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0169 0.7176
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.1773 0.1759
Entamoeba histolytica hypothetical protein 0.0133 0.0898 1
Schistosoma mansoni tyrosine kinase 0.0137 0.0932 0.0916
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0133 0.0898 0.0882
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0044 0.0214 0.0197
Loa Loa (eye worm) hypothetical protein 0.0072 0.0432 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0044 0.0214 0.0197
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0411 0.3043 0.3031
Onchocerca volvulus 0.1315 1 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0246 0.1773 0.2431
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0018 0.0017 0.0011
Brugia malayi Cation transporter family protein 0.0246 0.1773 0.1759
Schistosoma mansoni protein kinase 0.0044 0.0214 0.0197
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0246 0.1773 0.2439
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0246 0.1773 0.1759
Schistosoma mansoni serine/threonine protein kinase 0.0889 0.6719 0.6714
Trichomonas vaginalis CK1 family protein kinase 0.0044 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.1315 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.1773 0.1759
Schistosoma mansoni nAChR subunit 0.0246 0.1773 0.1759
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0114 0.0751 0.0735
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0017 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.2601
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.1773 0.2439
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0411 0.3043 0.419
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.1773 0.1759
Plasmodium falciparum casein kinase 1 0.0044 0.0214 0.5
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0246 0.1773 0.1759
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0411 0.3043 0.4196
Echinococcus multilocularis casein kinase i 0.0044 0.0214 0.0283
Brugia malayi hypothetical protein 0.0114 0.0751 0.0735
Schistosoma mansoni neurotransmitter gated ion channel 0.0114 0.0751 0.0735
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0039
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Onchocerca volvulus 0.0114 0.0751 0.0592
Echinococcus multilocularis epidermal growth factor receptor 0.0065 0.0376 0.0507
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0044 0.0214 1
Echinococcus granulosus glycine receptor subunit beta 0.0246 0.1773 0.2431
Loa Loa (eye worm) hypothetical protein 0.0246 0.1773 0.1759
Trypanosoma brucei unspecified product 0.0023 0.0056 0.2601
Echinococcus granulosus casein kinase i 0.0044 0.0214 0.0273
Onchocerca volvulus 0.0246 0.1773 0.1631
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0246 0.1773 0.1759
Brugia malayi casein kinase I 0.0044 0.0214 0.0197
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.1773 0.2439
Brugia malayi hypothetical protein 0.0114 0.0751 0.0735
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.1315 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.0064
Loa Loa (eye worm) hypothetical protein 0.0114 0.0751 0.0735
Brugia malayi Furin-like cysteine rich region family protein 0.0065 0.0376 0.0359
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.2601
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.1773 0.1759
Schistosoma mansoni neurotransmitter gated ion channel 0.0114 0.0751 0.0735
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.1773 0.2431

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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