TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 569.674 | Formula: C31H31N5O4S
H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccc(c2c1c1ccccc1s2)c1cccn2c1nc(cc2=O)N1CCOCC1)CCN1CCOCC1
InChi: 1S/C31H31N5O4S/c37-27(9-11-34-12-16-39-17-13-34)32-24-8-7-21(30-29(24)23-4-1-2-6-25(23)41-30)22-5-3-10-36-28(38)20-26(33-31(22)36)35-14-18-40-19-15-35/h1-8,10,20H,9,11-19H2,(H,32,37)
InChiKey: RCBKIBVIUKBMFX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0557	0.0822
Echinococcus granulosus	acetylcholinesterase	0.0134	0.4651	0.6865
Echinococcus granulosus	carboxylesterase 5A	0.0134	0.4651	0.6865
Schistosoma mansoni	aldo-keto reductase	0.0185	0.6774	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0054	0.1291	0.1599
Trypanosoma cruzi	aldo/keto reductase, putative	0.0054	0.1291	0.1599
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0036	0.0557	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0557	0.0822
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0036	0.0557	0.0822
Brugia malayi	NADH-dependent xylose reductase	0.0054	0.1291	0.1905
Mycobacterium leprae	Conserved hypothetical protein	0.0131	0.4538	0.6277
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0861	0.0942
Trichomonas vaginalis	esterase, putative	0.0041	0.0768	0.1133
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0185	0.6774	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0043	0.0861	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0583	0.0861
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0185	0.6774	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0054	0.1291	0.0726
Trypanosoma brucei	aldo/keto reductase, putative	0.0054	0.1291	0.1599
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0054	0.1291	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0768	0.0768
Leishmania major	hypothetical protein, conserved	0.0041	0.0768	0.0799
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.1291	0.1905
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0185	0.6774	1
Schistosoma mansoni	protein phosphatase 2C	0.0036	0.0557	0.0822
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0037	0.0583	0.0861
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Plasmodium vivax	JmjC domain containing protein	0.0036	0.0557	0.2971
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0768	0.0768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0043	0.0861	0.5
Schistosoma mansoni	pol-related	0.0185	0.6774	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0185	0.6774	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0139	0.487	0.487
Brugia malayi	hypothetical protein	0.0029	0.0246	0.0364
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0583	0.0861
Plasmodium vivax	aldehyde reductase, putative	0.0054	0.1291	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0185	0.6774	1
Entamoeba histolytica	aldose reductase, putative	0.0185	0.6774	1
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0036	0.0557	0.0822
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0054	0.1291	0.1599
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0037	0.0583	0.0861
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0185	0.6774	1
Schistosoma mansoni	jumonji domain containing protein	0.0135	0.4688	0.692
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0768	0.1133
Brugia malayi	beta-lactamase family protein	0.0041	0.0768	0.1133
Brugia malayi	jmjC domain containing protein	0.0036	0.0557	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4651	0.6865
Echinococcus granulosus	acetylcholinesterase	0.0134	0.4651	0.6865
Toxoplasma gondii	aldose reductase, putative	0.0185	0.6774	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0768	0.1133
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.4651	0.6865
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0768	0.1133
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0768	0.1133
Toxoplasma gondii	aldo-keto reductase	0.0054	0.1291	0.1599
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0054	0.1291	0.1905
Entamoeba histolytica	aldose reductase, putative	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Brugia malayi	jmjC domain containing protein	0.0036	0.0557	0.0822
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Brugia malayi	jmjC domain containing protein	0.0036	0.0557	0.0822
Onchocerca volvulus		0.0185	0.6774	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0036	0.0557	0.0475
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0036	0.0557	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1133
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0043	0.0861	0.0942
Echinococcus granulosus	lysine specific demethylase 5A	0.0135	0.4688	0.692
Schistosoma mansoni	potassium channel beta	0.0054	0.1291	0.1905
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0043	0.0861	0.1272
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0768	0.0768
Onchocerca volvulus		0.0185	0.6774	1
Loa Loa (eye worm)	oxidoreductase	0.0185	0.6774	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1133
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0036	0.0557	0.0822
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0768	0.0799
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0043	0.0861	0.0861
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0557	0.0822
Echinococcus multilocularis	aldo keto reductase	0.0185	0.6774	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0768	0.1133
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0768	0.1133
Echinococcus multilocularis	acetylcholinesterase	0.0134	0.4651	0.6865
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0557	0.0822
Brugia malayi	beta-lactamase	0.0041	0.0768	0.1133
Loa Loa (eye worm)	oxidoreductase	0.0185	0.6774	1
Toxoplasma gondii	exonuclease III APE	0.0043	0.0861	0.0942
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0036	0.0557	0.0475
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0054	0.1291	0.1905
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0037	0.0583	0.0861
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1133
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0768	0.0799
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0054	0.1291	0.1599
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0036	0.0557	0.0475
Echinococcus granulosus	JmjC domain containing protein 4	0.0036	0.0557	0.0822
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0583	0.0861
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0768	0.0768
Giardia lamblia	Aldose reductase	0.0185	0.6774	1
Brugia malayi	Carboxylesterase family protein	0.0134	0.4651	0.6865
Loa Loa (eye worm)	oxidoreductase	0.0185	0.6774	1
Schistosoma mansoni	ap endonuclease	0.0043	0.0861	0.1272
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0139	0.487	0.719
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0054	0.1291	0.1905
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0861	0.589
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1133
Loa Loa (eye worm)	jmjC domain-containing protein	0.0135	0.4688	0.692
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0768	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1133
Echinococcus granulosus	hypothetical protein	0.0185	0.6774	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Mycobacterium leprae	Possible oxidoreductase	0.0054	0.1291	0.087
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0185	0.6774	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0135	0.4688	0.692
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0043	0.0861	0.589
Echinococcus multilocularis	aldo keto reductase	0.0185	0.6774	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0139	0.487	0.719
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Onchocerca volvulus		0.0041	0.0768	0.1133
Schistosoma mansoni	aldehyde dehydrogenase	0.0139	0.487	0.719
Schistosoma mansoni	jumonji domain containing protein	0.0036	0.0557	0.0822
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0054	0.1291	0.0726
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0768	0.1133
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0139	0.487	0.719
Toxoplasma gondii	aldehyde dehydrogenase	0.0139	0.487	0.7083
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Echinococcus multilocularis	JmjC domain containing protein 4	0.0036	0.0557	0.0822
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0043	0.0861	0.1272
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0583	0.0861
Onchocerca volvulus		0.0041	0.0768	0.1133
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0139	0.487	0.719
Echinococcus multilocularis	jumonji domain containing 1A	0.0036	0.0557	0.0822
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0768	0.1133
Echinococcus granulosus	lysine specific demethylase 6a	0.0036	0.0557	0.0822
Loa Loa (eye worm)	oxidoreductase	0.0185	0.6774	1
Mycobacterium ulcerans	lipase LipD	0.0041	0.0768	0.1133
Leishmania major	hypothetical protein, conserved	0.0036	0.0557	0.0475
Onchocerca volvulus		0.0054	0.1291	0.1905
Leishmania major	aldo-keto reductase-like protein	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0185	0.6774	0.6774
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0557	0.0822
Mycobacterium ulcerans	hypothetical protein	0.0054	0.1291	0.1905
Echinococcus granulosus	aldo keto reductase	0.0185	0.6774	1
Leishmania major	prostaglandin f synthase, putative	0.0185	0.6774	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Onchocerca volvulus		0.0185	0.6774	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0054	0.1291	0.1905
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0185	0.6774	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0185	0.6774	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0135	0.4688	0.692
Mycobacterium ulcerans	oxidoreductase	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase	0.0185	0.6774	1
Giardia lamblia	Aldose reductase	0.0185	0.6774	1
Echinococcus multilocularis	phd:f box containing protein	0.0036	0.0557	0.0822
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0768	0.0768
Echinococcus multilocularis	aldehyde reductase	0.0131	0.4538	0.6699
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0768	0.1133
Echinococcus multilocularis	acetylcholinesterase	0.0134	0.4651	0.6865
Loa Loa (eye worm)	acetylcholinesterase 1	0.0134	0.4651	0.6865
Trichomonas vaginalis	aldo-keto reductase, putative	0.0054	0.1291	0.1905
Mycobacterium tuberculosis	Conserved protein	0.0054	0.1291	0.1291
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0054	0.1291	0.1905
Toxoplasma gondii	ABC1 family protein	0.0041	0.0768	0.0799
Brugia malayi	jmjC domain containing protein	0.0036	0.0557	0.0822
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0861	0.1272
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0134	0.4651	0.6865
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0768	0.0768
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0768	0.1133
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0185	0.6774	1
Echinococcus multilocularis	lysine specific demethylase 6a	0.0036	0.0557	0.0822
Schistosoma mansoni	ap endonuclease	0.0043	0.0861	0.1272
Trypanosoma brucei	prostaglandin f synthase	0.0185	0.6774	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0185	0.6774	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0185	0.6774	1
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0768	0.0768
Loa Loa (eye worm)	carboxylesterase	0.0134	0.4651	0.6865
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0043	0.0861	0.1272
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0768	0.1133
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0768	0.0768
Loa Loa (eye worm)	oxidoreductase	0.0185	0.6774	1
Echinococcus multilocularis	carboxylesterase 5A	0.0134	0.4651	0.6865
Echinococcus granulosus	phd:f box containing protein	0.0036	0.0557	0.0822
Schistosoma mansoni	phosphatidylserine receptor	0.0036	0.0557	0.0822
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0246	0.0364
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0135	0.4688	0.692
Onchocerca volvulus		0.0185	0.6774	1
Echinococcus granulosus	voltage gated potassium channel subunit	0.0054	0.1291	0.1905
Schistosoma mansoni	phd/f-box containing protein	0.0036	0.0557	0.0822
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0768	0.1133
Echinococcus granulosus	aldo keto reductase	0.0185	0.6774	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0557	0.0822
Echinococcus granulosus	aldo keto reductase	0.0185	0.6774	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0185	0.6774	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0054	0.1291	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0185	0.6774	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0768	0.4992
Entamoeba histolytica	aldose reductase, putative	0.0185	0.6774	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Brugia malayi	jmjC domain containing protein	0.0135	0.4688	0.692
Echinococcus granulosus	jumonji domain containing 1A	0.0036	0.0557	0.0822
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0043	0.0861	0.1272
Brugia malayi	exodeoxyribonuclease III family protein	0.0043	0.0861	0.1272
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0036	0.0557	0.2971
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0768	0.1133
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0139	0.487	0.7083
Schistosoma mansoni	aldo-keto reductase	0.0185	0.6774	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0037	0.0583	0.0861
Trypanosoma brucei	aldo-keto reductase, putative	0.0185	0.6774	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0768	0.1133
Echinococcus granulosus	aldehyde reductase	0.0131	0.4538	0.6699
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0768	0.1133
Brugia malayi	jmjC domain containing protein	0.0135	0.4688	0.692
Echinococcus multilocularis	lysine specific demethylase 5A	0.0135	0.4688	0.692
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1133
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0768	0.1133
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0054	0.1291	0.1905
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0043	0.0861	0.0942
Onchocerca volvulus		0.0185	0.6774	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0768	0.1133
Onchocerca volvulus		0.0041	0.0768	0.1133
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0043	0.0861	0.0942
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0768	0.0768
Trichomonas vaginalis	aldo-keto reductase, putative	0.0054	0.1291	0.1905
Trichomonas vaginalis	ap endonuclease, putative	0.0043	0.0861	0.1272
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0139	0.487	0.719
Brugia malayi	Carboxylesterase family protein	0.0134	0.4651	0.6865
Schistosoma mansoni	aldehyde dehydrogenase	0.0139	0.487	0.719
Trichomonas vaginalis	aldo-keto reductase, putative	0.0185	0.6774	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0185	0.6774	1
Plasmodium falciparum	aldehyde reductase, putative	0.0054	0.1291	1
Trypanosoma cruzi	aldo-keto reductase	0.0185	0.6774	1
Onchocerca volvulus		0.0185	0.6774	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0037	0.0583	0.0861
Echinococcus multilocularis	aldo keto reductase	0.0185	0.6774	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0135	0.4688	0.692

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1630129

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1462549