Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0135 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0135 | 0.0057 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0135 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0135 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0135 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.1354 | 0.1235 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0135 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0135 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0079 | 0.5808 |
Onchocerca volvulus | 0.0043 | 0.0135 | 1 | |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0135 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0079 | 0.5808 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0135 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0135 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.194 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0135 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.194 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0079 | 0.5808 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0135 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0135 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0079 | 0.5808 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0076 | 0.5579 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0135 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0135 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0135 | 1 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0548 | 0.2758 | 0.2658 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0135 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0135 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0135 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0135 | 1 |
Onchocerca volvulus | 0.0043 | 0.0135 | 1 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0135 | 0.0057 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0079 | 0.5808 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0135 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.194 | 1 | 1 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0548 | 0.2758 | 0.2658 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0548 | 0.2758 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.