Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | insulin receptor | Starlite/ChEMBL | References |
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0071 | 0.0337 | 0.045 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1128 | 0.7473 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1502 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.0935 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0442 | 0.0441 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1128 | 0.7473 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0089 | 0.0458 | 0.0457 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0073 | 0.0353 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.1502 | 1 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.0027 | 0.0036 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0073 | 0.0353 | 0.0472 |
Schistosoma mansoni | tyrosine kinase | 0.0073 | 0.0353 | 0.0471 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1128 | 0.7473 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0159 | 0.0935 | 0.0933 |
Echinococcus multilocularis | insulin receptor | 0.0159 | 0.0935 | 0.1251 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0073 | 0.0353 | 0.0438 |
Echinococcus granulosus | insulin receptor | 0.0159 | 0.0935 | 0.1219 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1502 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1502 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1128 | 0.7473 | 0.7473 |
Schistosoma mansoni | tyrosine kinase | 0.0073 | 0.0353 | 0.0471 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1128 | 0.7473 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.0935 | 0.1249 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0159 | 0.0935 | 0.0933 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1128 | 0.7473 | 0.7473 |
Schistosoma mansoni | tyrosine kinase | 0.0071 | 0.0337 | 0.045 |
Schistosoma mansoni | tyrosine kinase | 0.0073 | 0.0353 | 0.0471 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0073 | 0.0353 | 0.0352 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0159 | 0.0935 | 0.1219 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0159 | 0.0935 | 0.1251 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0027 | 0.0026 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0073 | 0.0353 | 0.0472 |
Schistosoma mansoni | tyrosine kinase | 0.0071 | 0.0337 | 0.045 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0073 | 0.0353 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.5043 | 0.5042 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0073 | 0.0353 | 0.0438 |
Brugia malayi | plexin A | 0.0025 | 0.0027 | 0.0026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.