Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0472 | 0.1227 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.1833 | 0.9507 | 0.9505 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0952 | 0.4143 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0277 | 0.0036 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0952 | 0.4143 | 0.4122 |
Brugia malayi | Protein kinase c protein 2 | 0.0654 | 0.2334 | 0.5596 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0925 | 0.3982 | 0.9608 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0952 | 0.4143 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0431 | 0.0973 | 0.2281 |
Toxoplasma gondii | AGC kinase | 0.0277 | 0.0036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0973 | 0.094 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0925 | 0.3982 | 0.9608 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1637 | 0.8316 | 0.831 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0463 | 0.117 | 0.2761 |
Loa Loa (eye worm) | hypothetical protein | 0.1637 | 0.8316 | 0.831 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0431 | 0.0973 | 0.2281 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0459 | 0.1143 | 0.1111 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.2164 | 0.2135 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0925 | 0.3982 | 0.9608 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0925 | 0.3982 | 0.9608 |
Loa Loa (eye worm) | hypothetical protein | 0.1637 | 0.8316 | 0.831 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0729 | 0.2791 | 0.6709 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0952 | 0.4143 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0472 | 0.1227 | 0.29 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0729 | 0.2791 | 0.6709 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0463 | 0.117 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0472 | 0.1227 | 0.29 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Onchocerca volvulus | 0.1637 | 0.8316 | 0.5 | |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0734 | 0.2818 | 0.6774 |
Brugia malayi | protein kinase C II. | 0.0952 | 0.4143 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0277 | 0.0036 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0431 | 0.0973 | 0.2281 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20.8 nM | Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counting | ChEMBL. | 21193308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.