Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 2 | 872 aa | 892 aa | 26.9 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 2 | 872 aa | 883 aa | 43.3 % |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 2 | 872 aa | 822 aa | 21.2 % |
Onchocerca volvulus | Metabotropic glutamate receptor 2 | 872 aa | 774 aa | 20.4 % | |
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 2 | 872 aa | 884 aa | 35.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0092 | 0.302 | 0.7033 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.1245 | 0.1245 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3854 | 0.2748 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0092 | 0.302 | 0.7033 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.1525 | 0.1525 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0065 | 0.1736 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Schistosoma mansoni | endonuclease related | 0.0065 | 0.1736 | 0.1736 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.2212 | 0.0811 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0065 | 0.1736 | 0.1736 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.1042 | 0.1042 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0065 | 0.1736 | 0.5 |
Leishmania major | endonuclease G, putative | 0.0065 | 0.1736 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.2212 | 0.4161 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3854 | 0.2748 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0065 | 0.1736 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0065 | 0.1736 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.1933 | 0.1933 |
Trypanosoma brucei | endonuclease G, putative | 0.0065 | 0.1736 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0235 | 1 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0109 | 0.3854 | 0.3854 |
Echinococcus multilocularis | ectonucleotide | 0.0092 | 0.302 | 0.7033 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.3854 | 0.3854 |
Onchocerca volvulus | 0.0235 | 1 | 1 | |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.2212 | 0.4161 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0065 | 0.1736 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0092 | 0.302 | 0.7033 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0065 | 0.1736 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0065 | 0.1736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.302 | 0.1764 |
Echinococcus multilocularis | Endonuclease G | 0.0065 | 0.1736 | 0.2469 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3854 | 0.2748 |
Trypanosoma cruzi | endonuclease G, putative | 0.0065 | 0.1736 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.3854 | 0.3854 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.3854 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.3854 | 0.3854 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0235 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.3854 | 0.3854 |
Echinococcus granulosus | Endonuclease G | 0.0065 | 0.1736 | 0.2469 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.013 uM | Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | ChEMBL. | 20971004 |
IC50 (functional) | = 0.016 uM | Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP production | ChEMBL. | 20971004 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.