Detailed information for compound 1472434

Basic information

Technical information
  • TDR Targets ID: 1472434
  • Name: 4-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)-1,3 -thiazol-2-amine
  • MW: 233.333 | Formula: C12H15N3S
  • H donors: 1 H acceptors: 1 LogP: 2.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(C)cc(c1C)c1csc(n1)N
  • InChi: 1S/C12H15N3S/c1-4-5-15-8(2)6-10(9(15)3)11-7-16-12(13)14-11/h4,6-7H,1,5H2,2-3H3,(H2,13,14)
  • InChiKey: ZNQGDRYCUALLNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(1-allyl-2,5-dimethyl-pyrrol-3-yl)thiazol-2-amine
  • 4-(1-allyl-2,5-dimethyl-3-pyrrolyl)-2-thiazolamine
  • [4-(1-allyl-2,5-dimethyl-pyrrol-3-yl)thiazol-2-yl]amine
  • 4-(2,5-dimethyl-1-prop-2-enyl-pyrrol-3-yl)-1,3-thiazol-2-amine
  • ZINC03351134

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide receptor 0.0055 0.0523 0.0523
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Schistosoma mansoni biogenic amine receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0026 0.0103 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0026 0.0103 0.1787
Plasmodium vivax potassium channel, putative 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0523 0.0523
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Schistosoma mansoni calcium-activated potassium channel 0.0711 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0523 0.0523
Plasmodium falciparum potassium channel 0.0026 0.0103 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Echinococcus granulosus calcium activated potassium channel variant 0.0026 0.0103 0.0103
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0523 0.0523
Echinococcus multilocularis potassium channel subfamily K 8 0.0026 0.0103 0.0103
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0577 0.0577
Echinococcus granulosus g protein coupled receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0523 0.0523
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0026 0.0103 0.0103
Brugia malayi jmjC domain containing protein 0.0059 0.0577 1
Onchocerca volvulus 0.0026 0.0103 0.1763
Onchocerca volvulus 0.0026 0.0103 0.1763
Echinococcus multilocularis serotonin receptor 0.0319 0.4346 0.4346
Brugia malayi hypothetical protein 0.0026 0.0103 0.1787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni neuropeptide receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0523 0.0523
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0523 0.0523
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Echinococcus granulosus serotonin receptor 0.0055 0.0523 0.0523
Onchocerca volvulus 0.0055 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0026 0.0103 0.1763
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0026 0.0103 0.0103
Schistosoma mansoni neuropeptide receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis small conductance calcium activated potassium 0.0711 1 1
Schistosoma mansoni calcium-activated potassium channel 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0523 0.0523
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Brugia malayi G protein-coupled receptor 0.0055 0.0523 0.9073
Schistosoma mansoni hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0523 0.0523
Schistosoma mansoni biogenic amine (5HT) receptor 0.0319 0.4346 0.4346
Schistosoma mansoni hypothetical protein 0.0055 0.0523 0.0523
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis calcium activated potassium channel variant 0.0026 0.0103 0.0103
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0523 0.0523
Schistosoma mansoni opsin-like receptor 0.0055 0.0523 0.0523
Schistosoma mansoni amine GPCR 0.0055 0.0523 0.0523
Mycobacterium ulcerans transmembrane cation transporter 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0523 0.0523
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus potassium channel subfamily K 8 0.0026 0.0103 0.0103
Echinococcus granulosus twik family of potassium channels 0.0026 0.0103 0.0103
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.968 0.968
Brugia malayi Dopamine receptor protein 1 0.0055 0.0523 0.9073
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0569 0.877
Echinococcus granulosus neuropeptide receptor 0.0055 0.0523 0.0523
Onchocerca volvulus 0.0055 0.0523 1
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0026 0.0103 0.0103
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0266 0.3578 0.3578
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0523 0.0523
Giardia lamblia Hypothetical protein 0.0026 0.0103 1
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Leishmania major cathepsin L-like protease 0.0064 0.0649 1
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0523 0.0523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Plasmodium falciparum potassium channel 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni histamine h1 receptor 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0026 0.0103 0.1787
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0523 0.0523
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0523 0.0523
Echinococcus granulosus g protein coupled receptor 0.0055 0.0523 0.0523
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0523 0.0523
Trypanosoma cruzi ion transport protein, putative 0.0026 0.0103 0.1589
Onchocerca volvulus 0.0055 0.0523 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0026 0.0103 0.1787
Leishmania major hypothetical protein, conserved 0.0026 0.0103 0.1589
Brugia malayi putative neuropeptide receptor 0.0055 0.0523 0.9073
Brugia malayi ORL1-like opioid receptor 0.0055 0.0523 0.9073
Schistosoma mansoni amine GPCR 0.0055 0.0523 0.0523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0523 0.0523
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0523 0.9073
Brugia malayi hypothetical protein 0.002 0.0013 0.0227
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0649 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0577 0.0577
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0525 0.0525
Onchocerca volvulus 0.0055 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus allatostatin A receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0523 0.0523
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0013 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0523 0.0523
Echinococcus granulosus biogenic amine 5HT receptor 0.0319 0.4346 0.4346
Loa Loa (eye worm) hypothetical protein 0.0179 0.2323 0.2323
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0523 0.0523
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0577 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Echinococcus granulosus hypothetical protein 0.0055 0.0523 0.0523
Onchocerca volvulus 0.0026 0.0103 0.1763
Schistosoma mansoni calcium-activated potassium channel 0.0026 0.0103 0.0103
Echinococcus multilocularis somatostatin receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0523 0.0523
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0026 0.0103 0.1589
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0523 0.0523
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0577 0.0577
Brugia malayi RE15519p 0.0055 0.0523 0.9073
Brugia malayi Serotonin receptor 0.0055 0.0523 0.9073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Echinococcus granulosus potassium channel subfamily K 8 0.0026 0.0103 0.0103
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0026 0.0103 0.1589
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Brugia malayi Dopamine receptor 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0711 1 1
Schistosoma mansoni neuropeptide receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0523 0.0523
Schistosoma mansoni myosin xvIII 0.0055 0.0523 0.0523
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Onchocerca volvulus 0.0055 0.0523 1
Echinococcus granulosus twik family of potassium channels 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0055 0.0523 1
Brugia malayi neuropeptide F receptor 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0026 0.0103 0.1787
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0523 0.0523
Brugia malayi Melatonin receptor type 1A 0.0055 0.0523 0.9073
Schistosoma mansoni hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0523 0.0523
Brugia malayi Dopamine receptor protein 2 0.0055 0.0523 0.9073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0523 0.0523
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0026 0.0103 0.1787
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0523 0.0523
Schistosoma mansoni opsin-like receptor 0.0055 0.0523 0.0523
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0523 0.0523
Schistosoma mansoni hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus potassium channel subfamily K 0.0026 0.0103 0.0103
Echinococcus multilocularis potassium channel subfamily K 0.0026 0.0103 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0649 1
Onchocerca volvulus 0.0055 0.0523 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0523 0.0523
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0523 0.0523
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0026 0.0103 0.1589
Schistosoma mansoni calcium-activated potassium channel 0.0505 0.7032 0.7032
Brugia malayi jmjC domain containing protein 0.0059 0.0577 1
Schistosoma mansoni amine GPCR 0.0055 0.0523 0.0523
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0013 0.0013
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0525 0.0525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Trypanosoma brucei calcium-activated potassium channel, putative 0.0026 0.0103 0.1589
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0523 0.9073
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0523 0.9073
Toxoplasma gondii ion channel protein 0.0026 0.0103 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0523 0.0523
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.968 0.968
Brugia malayi hypothetical protein 0.002 0.0013 0.0227
Leishmania major ion transport protein-like protein 0.0026 0.0103 0.1589
Echinococcus granulosus somatostatin receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Mycobacterium ulcerans ion transport protein 0.0026 0.0103 1
Leishmania major cathepsin L-like protease 0.0064 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0523 0.0523
Brugia malayi Serotonin receptor 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis serotonin receptor 0.0319 0.4346 0.4346
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0055 0.0523 1
Toxoplasma gondii ion channel protein 0.0026 0.0103 1
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0523 0.0523
Leishmania major potassium channel subunit-like protein 0.0026 0.0103 0.1589
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0055 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0013 0.0013
Trypanosoma cruzi ion transport protein, putative 0.0026 0.0103 0.1589
Loa Loa (eye worm) TWK-7 protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis twik family of potassium channels 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0103 1
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0523 0.0523
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0013 0.1272
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0026 0.0103 0.1787
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0523 0.0523
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0026 0.0103 0.1763
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0523 0.0523
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0523 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis sex peptide receptor 0.0055 0.0523 0.0523
Schistosoma mansoni lipoxygenase 0.0055 0.0525 0.0525
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0026 0.0103 0.1787
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0577 0.0577
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0523 0.0523
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0026 0.0103 0.1787
Schistosoma mansoni hypothetical protein 0.0026 0.0103 0.0103
Schistosoma mansoni adenoreceptor 0.0055 0.0523 0.0523
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0319 0.4346 0.4346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0026 0.0103 0.1589
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0523 0.0523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni rab6-interacting 0.002 0.0013 0.0013
Echinococcus granulosus fmrfamide receptor 0.0055 0.0523 0.0523
Onchocerca volvulus 0.0055 0.0523 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0381 0.0381
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0026 0.0103 0.1787
Brugia malayi AKH receptor 0.0055 0.0523 0.9073
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0523 0.0523
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0103 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0026 0.0103 0.1787
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0103 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0523 0.0523
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0523 0.0523
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0523 0.0523
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0523 0.0523
Echinococcus granulosus orexin receptor type 2 0.0055 0.0523 0.0523
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0577 0.0577
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0523 0.0523
Brugia malayi Cytochrome P450 family protein 0.0045 0.0381 0.6607
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0523 0.0523
Schistosoma mansoni amine GPCR 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0523 0.0523
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0523 0.0523
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Brugia malayi Doublecortin family protein 0.002 0.0013 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0103 0.1589
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni biogenic amine receptor 0.0055 0.0523 0.0523
Echinococcus granulosus g protein coupled receptor 0.0055 0.0523 0.0523
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0013 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0026 0.0103 0.1787
Brugia malayi G-protein coupled receptor 0.0055 0.0523 0.9073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Schistosoma mansoni twik family of potassium channels-related 0.0026 0.0103 0.0103
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0523 0.0523
Brugia malayi neuropeptide F receptor 0.0055 0.0523 0.9073
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0026 0.0103 0.1787
Brugia malayi sulfakinin receptor protein 0.0055 0.0523 0.9073
Schistosoma mansoni opsin-like receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0239 0.3183 0.3183
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Loa Loa (eye worm) doublecortin family protein 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0013 0.0013
Onchocerca volvulus 0.0055 0.0523 1
Onchocerca volvulus 0.0055 0.0523 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Brugia malayi G-protein coupled receptor 0.0055 0.0523 0.9073
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0523 0.0523
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0523 0.0523
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0523 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Onchocerca volvulus 0.0055 0.0523 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0026 0.0103 0.1787
Brugia malayi hypothetical protein 0.0055 0.0523 0.9073
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0577 0.0577
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0523 0.0523
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0026 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Onchocerca volvulus 0.0055 0.0523 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0523 0.0523
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0523 0.0523
Loa Loa (eye worm) uncoordinated protein 58 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0055 0.0523 1
Schistosoma mansoni rab6-interacting 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Echinococcus granulosus sex peptide receptor 0.0055 0.0523 0.0523
Leishmania major calcium/potassium channel (CAKC), putative 0.0026 0.0103 0.1589
Onchocerca volvulus 0.0026 0.0103 0.1763
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni amine GPCR 0.0055 0.0523 0.0523
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Brugia malayi larval opioid receptor 0.0055 0.0523 0.9073
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0523 1
Schistosoma mansoni biogenic amine receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus microtubule associated protein 2 0.0688 0.968 0.968
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0452 0.6965
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis potassium channel subfamily K 8 0.0026 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0013
Echinococcus granulosus RUN 0.002 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0711 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0026 0.0103 0.0103
Onchocerca volvulus 0.0026 0.0103 0.1763
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0026 0.0103 0.1787
Loa Loa (eye worm) hypothetical protein 0.0319 0.4346 0.4346
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0523 0.0523
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0013 0.1272
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0026 0.0103 0.1589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Leishmania major hypothetical protein, conserved 0.0026 0.0103 0.1589
Echinococcus multilocularis RUN 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Plasmodium vivax potassium channel, putative 0.0026 0.0103 1
Onchocerca volvulus 0.0055 0.0523 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Leishmania major cathepsin L-like protease 0.0064 0.0649 1
Schistosoma mansoni lipoxygenase 0.002 0.0013 0.0013
Loa Loa (eye worm) TWK-28 protein 0.0026 0.0103 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0523 0.0523
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0649 1
Schistosoma mansoni neuropeptide receptor 0.0055 0.0523 0.0523
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0523 0.0523
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Schistosoma mansoni loxhd1 0.002 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0523 0.0523
Onchocerca volvulus 0.0055 0.0523 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0523 0.0523
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0026 0.0103 1
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0523 0.9073
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0523 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0649 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0523 0.0523
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0026 0.0103 0.1787
Schistosoma mansoni polycystin 1-related 0.002 0.0013 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0026 0.0103 0.1787
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0577 0.0577
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0026 0.0103 0.1787
Onchocerca volvulus 0.0026 0.0103 0.1763
Brugia malayi hypothetical protein 0.0026 0.0103 0.1787
Brugia malayi GnHR receptor homolog 0.0055 0.0523 0.9073
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0523 0.0523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis twik family of potassium channels 0.0026 0.0103 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0103 0.1589

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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