Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0308 | 0.2434 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2285 | 0.166 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0213 | 0.102 | 0.1027 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0605 | 0.6863 | 1 |
Loa Loa (eye worm) | trehalase | 0.0298 | 0.2285 | 0.166 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0308 | 0.2434 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0605 | 0.6863 | 0.6609 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0308 | 0.2434 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0605 | 0.6863 | 1 |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0144 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0605 | 0.6863 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0298 | 0.2285 | 0.9054 |
Mycobacterium leprae | Possible hydrolase | 0.0144 | 0 | 0.5 |
Onchocerca volvulus | 0.0298 | 0.2285 | 0.4681 | |
Schistosoma mansoni | alpha-glucosidase | 0.0605 | 0.6863 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0308 | 0.2434 | 0.0326 |
Onchocerca volvulus | 0.0298 | 0.2285 | 0.4681 | |
Onchocerca volvulus | 0.0298 | 0.2285 | 0.4681 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0308 | 0.2434 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2285 | 0.166 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0308 | 0.2434 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2285 | 0.166 |
Onchocerca volvulus | 0.0407 | 0.3906 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0213 | 0.102 | 0.1027 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0144 | 0 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0308 | 0.2434 | 0.1822 |
Onchocerca volvulus | Trehalase homolog | 0.0298 | 0.2285 | 0.4681 |
Loa Loa (eye worm) | trehalase | 0.0298 | 0.2285 | 0.166 |
Trichomonas vaginalis | trehalase, putative | 0.0298 | 0.2285 | 0.9054 |
Mycobacterium tuberculosis | Conserved protein | 0.0144 | 0 | 0.5 |
Loa Loa (eye worm) | trehalase | 0.0298 | 0.2285 | 0.166 |
Onchocerca volvulus | 0.0298 | 0.2285 | 0.4681 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0605 | 0.6863 | 1 |
Loa Loa (eye worm) | TRE-1 protein | 0.0298 | 0.2285 | 0.166 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0144 | 0 | 0.5 |
Leishmania major | glycosyl hydrolase, putative | 0.0144 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2285 | 0.166 |
Loa Loa (eye worm) | TRE-2 protein | 0.0298 | 0.2285 | 0.166 |
Onchocerca volvulus | 0.0298 | 0.2285 | 0.4681 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0605 | 0.6863 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0308 | 0.2434 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2285 | 0.166 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.3538 | 0.3015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 7 mg kg-1 | Effective dose against passive cutaneous anaphylaxis when administered perorally. | ChEMBL. | 2578192 |
I50 (functional) | = 10 uM | Concentration required to inhibit antigen-induced release of histamine (AIR) by 50% from passively sensitized rat mast cells | ChEMBL. | 2578192 |
Inhibition (functional) | = 77 % | Inhibition of antigen-induced release of histamine at a dose of 25 mg/kg in passive cutaneous anaphylaxis in the male Sprague-Dawley rats | ChEMBL. | 2578192 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.