Detailed information for compound 1475588

Basic information

Technical information
  • TDR Targets ID: 1475588
  • Name: 2-methylsulfanyl-1-[2-(phenoxy)ethyl]-4,5-dih ydroimidazole
  • MW: 236.333 | Formula: C12H16N2OS
  • H donors: 0 H acceptors: 0 LogP: 2.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSC1=NCCN1CCOc1ccccc1
  • InChi: 1S/C12H16N2OS/c1-16-12-13-7-8-14(12)9-10-15-11-5-3-2-4-6-11/h2-6H,7-10H2,1H3
  • InChiKey: PRVUBSGYYOKIQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(methylthio)-1-[2-(phenoxy)ethyl]-4,5-dihydroimidazole
  • EU-0075519

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0028 0.0153 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.1762
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0254 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0254 0.0623
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0238 0.1442 0.9246
Loa Loa (eye worm) dUTP diphosphatase 0.0238 0.1442 1
Mycobacterium ulcerans thymidine phosphorylase 0.0612 0.3743 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0117
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0254 0.1569
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0153 0.0848
Trypanosoma cruzi thymidine kinase, putative 0.0257 0.156 0.5
Echinococcus multilocularis dUTP pyrophosphatase 0.0238 0.1442 0.1423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.1762
Echinococcus granulosus neuropeptide s receptor 0.0478 0.2918 0.7782
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Entamoeba histolytica hypothetical protein 0.0155 0.0934 0.5991
Trypanosoma cruzi thymidine kinase, putative 0.0257 0.156 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Brugia malayi dUTP diphosphatase 0.0238 0.1442 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0347 0.2403
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Entamoeba histolytica hypothetical protein 0.0238 0.1442 0.9246
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0238 0.1442 0.9246
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0238 0.1442 1
Trichomonas vaginalis thymidine kinase, putative 0.0257 0.156 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0254 0.0623
Trichomonas vaginalis thymidine kinase, putative 0.0257 0.156 1
Schistosoma mansoni cpg binding protein 0.0028 0.0153 0.1058
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0238 0.1442 0.9246
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0238 0.1442 0.9246
Trichomonas vaginalis thymidine kinase, putative 0.0257 0.156 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0254 0.0232
Echinococcus granulosus cpg binding protein 0.003 0.0162 0.0376
Trichomonas vaginalis helicase, putative 0.0006 0.0019 0.0117
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0238 0.1442 1
Echinococcus granulosus dUTP pyrophosphatase 0.0238 0.1442 0.3816
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0173 0.1042 0.1703
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0023 0.0156
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0238 0.1442 0.5
Entamoeba histolytica hypothetical protein 0.0155 0.0934 0.5991
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0238 0.1442 1
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0173 0.1042 0.1703
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0083 0.0487 0.3125
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0238 0.1442 0.5
Leishmania major thymidine kinase, putative 0.0257 0.156 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0478 0.2918 0.2902
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0254 0.1573
Echinococcus multilocularis neuropeptide receptor A26 0.0478 0.2918 0.2902
Entamoeba histolytica thymidine kinase, putative 0.0257 0.156 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0238 0.1442 1
Schistosoma mansoni cpg binding protein 0.003 0.0162 0.1126
Entamoeba histolytica hypothetical protein 0.0238 0.1442 0.9246
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0004 0.0031
Giardia lamblia Thymidine kinase 0.0257 0.156 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0117
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0083 0.0487 0.3125
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0173 0.1042 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0153 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0117
Echinococcus multilocularis cpg binding protein 0.003 0.0162 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0117
Echinococcus multilocularis thymidine phosphorylase 0.0612 0.3743 0.3729
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0019 0.0117
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0238 0.1442 0.9246
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0011
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0238 0.1442 1
Schistosoma mansoni cpg binding protein 0.003 0.0162 0.1126
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0238 0.1442 0.9246
Trypanosoma brucei thymidine kinase 0.0257 0.156 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0019 0.0117
Entamoeba histolytica hypothetical protein 0.0083 0.0487 0.3125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.1762
Echinococcus granulosus thymidine phosphorylase 0.0612 0.3743 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0238 0.1442 0.9246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0117
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0033 0.0028
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0612 0.3743 1
Echinococcus granulosus neuropeptide receptor A26 0.0478 0.2918 0.7782

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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