Detailed information for compound 1477544

Basic information

Technical information
  • TDR Targets ID: 1477544
  • Name: 2-(2-imino-1,3-thiazol-3-yl)-N-[2-(phenoxy)ph enyl]acetamide
  • MW: 325.385 | Formula: C17H15N3O2S
  • H donors: 1 H acceptors: 1 LogP: 2.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1ccsc1=N)Nc1ccccc1Oc1ccccc1
  • InChi: 1S/C17H15N3O2S/c18-17-20(10-11-23-17)12-16(21)19-14-8-4-5-9-15(14)22-13-6-2-1-3-7-13/h1-11,18H,12H2,(H,19,21)
  • InChiKey: XSWLGKVTOCFBBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-iminothiazol-3-yl)-N-[2-(phenoxy)phenyl]acetamide
  • 2-(2-imino-3-thiazolyl)-N-[2-(phenoxy)phenyl]acetamide
  • 2-(2-imino-1,3-thiazol-3-yl)-N-[2-(phenoxy)phenyl]ethanamide
  • ZINC07191711

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0128 0.1266 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0128 0.1266 1
Echinococcus granulosus Dipeptidyl peptidase 9 0.0886 0.9871 0.987
Trypanosoma cruzi oligopeptidase b 0.0128 0.1266 0.1216
Brugia malayi Importin beta-1 subunit 0.0031 0.0167 0.0167
Echinococcus multilocularis lamin dm0 0.003 0.0157 0.0083
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0541 0.5959 1
Trypanosoma brucei prolyl endopeptidase 0.0128 0.1266 0.1216
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0101 0.0219
Trypanosoma brucei oligopeptidase b 0.0128 0.1266 0.1216
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0167 0.0093
Echinococcus granulosus geminin 0.0187 0.1944 0.1883
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0167 0.0156
Echinococcus multilocularis snurportin 1 0.0328 0.3536 0.3487
Schistosoma mansoni hypothetical protein 0.0328 0.3536 0.3487
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0151
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0128 0.1266 0.5
Echinococcus granulosus lamin 0.003 0.0157 0.0083
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.1266 0.1127
Schistosoma mansoni lamin 0.003 0.0157 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0472 0.5178 0.5178
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0128 0.1266 0.1216
Plasmodium falciparum importin beta, putative 0.0031 0.0167 0.0772
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0886 0.9871 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0128 0.1266 1
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.1266 1
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.1266 0.1216
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0157 0.0157
Leishmania major oligopeptidase b 0.0128 0.1266 0.1216
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0135 0.0102
Brugia malayi hypothetical protein 0.0028 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0187 0.1944 0.1883
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0898 1 1
Schistosoma mansoni hypothetical protein 0.0187 0.1944 0.1883
Entamoeba histolytica hypothetical protein 0.0025 0.0101 0.0219
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0886 0.9871 0.987
Echinococcus granulosus snurportin 1 0.0328 0.3536 0.3487
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0128 0.1266 0.1216
Brugia malayi hypothetical protein 0.0018 0.0023 0.0023
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0128 0.1266 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0075 0.0075
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.1266 0.1216
Loa Loa (eye worm) intermediate filament protein 0.003 0.0157 0.0157
Plasmodium falciparum peptidase, putative 0.0128 0.1266 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0128 0.1266 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0135 0.0061
Giardia lamblia Alanyl dipeptidyl peptidase 0.0128 0.1266 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0886 0.9871 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.1623 0.1623
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0135 0.0503
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.1266 0.1266
Entamoeba histolytica hypothetical protein, conserved 0.0128 0.1266 1
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.1266 0.1266
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0128 0.1266 0.5
Brugia malayi prolyl oligopeptidase family protein 0.0886 0.9871 0.9871
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0128 0.1266 0.1216
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.1266 0.12
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.1266 0.1216
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.1266 0.12
Schistosoma mansoni lamin 0.003 0.0157 0.0083
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0128 0.1266 0.1216
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0135 0.0503
Loa Loa (eye worm) prolyl oligopeptidase 0.0898 1 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0101 0.0027
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0886 0.9871 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0128 0.1266 0.12
Echinococcus multilocularis musashi 0.003 0.0157 0.0083
Loa Loa (eye worm) hypothetical protein 0.0128 0.1266 0.1266
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0101 0.0027
Toxoplasma gondii prolyl endopeptidase 0.0128 0.1266 0.2025
Brugia malayi RNA, U transporter 1 0.0087 0.0809 0.0809
Entamoeba histolytica prolyl oligopeptidase family protein 0.0128 0.1266 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0157
Mycobacterium tuberculosis Probable peptidase 0.0128 0.1266 0.5
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0328 0.3536 0.3536
Echinococcus multilocularis geminin 0.0187 0.1944 0.1883
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0128 0.1266 0.12
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0135
Echinococcus granulosus lamin dm0 0.003 0.0157 0.0083
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0128 0.1266 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0898 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0075 0.0075
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0128 0.1266 0.1216
Brugia malayi hypothetical protein 0.0414 0.4512 0.4512
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.1266 0.12
Trypanosoma cruzi oligopeptidase b 0.0128 0.1266 0.1216
Schistosoma mansoni intermediate filament proteins 0.003 0.0157 0.0083
Schistosoma mansoni importin beta-1 0.0031 0.0167 0.0093
Echinococcus granulosus importin subunit beta 1 0.0031 0.0167 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0135 0.0503
Leishmania major hypothetical protein, conserved 0.0028 0.0135 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0167 0.0094
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0135 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0135 0.0061
Echinococcus multilocularis lamin 0.003 0.0157 0.0083
Giardia lamblia Alanyl dipeptidyl peptidase 0.0128 0.1266 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0128 0.1266 0.12
Echinococcus granulosus muscleblind protein 0.0159 0.1623 0.1559
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0128 0.1266 0.2025
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0898 1 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0886 0.9871 0.987
Entamoeba histolytica prolyl oligopeptidase family protein 0.0128 0.1266 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0128 0.1266 0.1266
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0898 1 1
Brugia malayi Muscleblind-like protein 0.0159 0.1623 0.1623
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0157 0.0157
Toxoplasma gondii hypothetical protein 0.0128 0.1266 0.2025
Loa Loa (eye worm) hypothetical protein 0.0128 0.1266 0.1266
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.1266 0.12
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0128 0.1266 0.5
Echinococcus granulosus prolyl endopeptidase 0.0128 0.1266 0.12
Plasmodium vivax importin-beta 2, putative 0.0031 0.0167 0.0772
Loa Loa (eye worm) hypothetical protein 0.0159 0.1623 0.1623
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0886 0.9871 1
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.1266 0.1216
Loa Loa (eye worm) hypothetical protein 0.0414 0.4512 0.4512
Trypanosoma brucei prolyl oligopeptidase, putative 0.0128 0.1266 0.1216
Brugia malayi intermediate filament protein 0.003 0.0157 0.0157
Echinococcus multilocularis muscleblind protein 1 0.0159 0.1623 0.1559
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0167 0.0094
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0101 0.0219
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0886 0.9871 1
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.1266 0.1266
Echinococcus granulosus intermediate filament protein 0.003 0.0157 0.0083
Echinococcus multilocularis muscleblind protein 0.0159 0.1623 0.1559
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0101 0.0219

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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