Detailed information for compound 1477971

Basic information

Technical information
  • TDR Targets ID: 1477971
  • Name: 1-[(3-fluorophenyl)methyl]pyridin-4-imine
  • MW: 202.228 | Formula: C12H11FN2
  • H donors: 0 H acceptors: 0 LogP: 1.96 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=c1ccn(cc1)Cc1cccc(c1)F
  • InChi: 1S/C12H11FN2/c13-11-3-1-2-10(8-11)9-15-6-4-12(14)5-7-15/h1-8,14H,9H2
  • InChiKey: GTWSEKJNOZVTMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(3-fluorophenyl)methyl]-4-pyridinimine
  • [1-(3-fluorobenzyl)-4-pyridylidene]amine
  • Oprea1_792025
  • STOCK1S-12801
  • ZINC00494622

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Echinococcus multilocularis cyclin dependent kinase 9 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.3443 1
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0028 0.5
Brugia malayi Cell division protein kinase 2 0.0008 0.0028 0.008
Trypanosoma brucei protein kinase, putative 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Brugia malayi cyclin-dependent kinase 7 homolog 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.3443 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0008 0.0028 0.008
Giardia lamblia Kinase, CAMK CAMKL 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.3443 1
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis protein kinase atmrk1, putative 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.3443 1
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0008 0.0028 0.5
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Brugia malayi Protein kinase domain containing protein 0.0008 0.0028 0.008
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0111 0.9295 0.5
Schistosoma mansoni protein kinase 0.0008 0.0028 0.008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.3443 1
Giardia lamblia Kinase, CAMK CAMKL 0.0008 0.0028 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.3443 1
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.3443 1
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0008 0.0028 1
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Echinococcus granulosus serine:threonine protein kinase NLK 0.0008 0.0028 0.008
Giardia lamblia Kinase, CAMK CAMKL 0.0008 0.0028 0.5
Trichomonas vaginalis serine/threonine kinase, putative 0.0008 0.0028 0.5
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0008 0.0028 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0008 0.0028 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.3443 1
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0008 0.0028 0.5
Echinococcus granulosus cyclin dependent kinase 9 0.0008 0.0028 0.008
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0119 1 1
Loa Loa (eye worm) haspin protein kinase 0.0008 0.0028 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.3443 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0008 0.0028 1
Schistosoma mansoni serine/threonine kinase 0.0008 0.0028 0.008
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0008 0.0028 0.008
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0028 0.5
Echinococcus granulosus mitogen activated protein kinase 15 0.0008 0.0028 0.008
Leishmania major serine/threonine kinase-like protein, putative 0.0008 0.0028 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0008 0.0028 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.