Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0226 | 0.9216 | 0.9216 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0226 | 0.9216 | 0.9216 |
Plasmodium vivax | topoisomerase I, putative | 0.0226 | 0.9216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.6428 | 0.6975 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0169 | 0.6428 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0226 | 0.9216 | 1 |
Onchocerca volvulus | 0.0049 | 0.0545 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0342 | 0.0371 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0169 | 0.6428 | 1 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0226 | 0.9216 | 0.9216 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0342 | 0.0342 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0342 | 0.0371 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1172 | 0.5 |
Brugia malayi | DNA topoisomerase I | 0.0226 | 0.9216 | 0.9216 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1172 | 0.1272 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0545 | 0.0591 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0342 | 0.0342 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.1172 | 0.1172 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.1172 | 0.1172 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0 | 0.5 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0057 | 0.091 | 0.1415 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0342 | 0.0342 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.1172 | 0.1823 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0342 | 0.0371 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0342 | 0.0342 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1172 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0545 | 0.0545 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0057 | 0.091 | 0.1415 |
Plasmodium falciparum | topoisomerase I | 0.0226 | 0.9216 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.1172 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1172 | 0.1272 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0226 | 0.9216 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0545 | 0.0591 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.1172 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0169 | 0.6428 | 0.6975 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0057 | 0.091 | 0.1415 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0169 | 0.6428 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0342 | 0.0342 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0342 | 0.0342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | ChEMBL. | 8410981 |
IC50 (binding) | = 13 uM | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | ChEMBL. | 8410981 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.