Detailed information for compound 1478735

Basic information

Technical information
  • TDR Targets ID: 1478735
  • Name: 6-(4-chlorophenyl)-3-propan-2-yl-7H-[1,2,4]tr iazolo[3,4-b][1,3,4]thiadiazine
  • MW: 292.787 | Formula: C13H13ClN4S
  • H donors: 0 H acceptors: 2 LogP: 3.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1=Nn2c(SC1)nnc2C(C)C
  • InChi: 1S/C13H13ClN4S/c1-8(2)12-15-16-13-18(12)17-11(7-19-13)9-3-5-10(14)6-4-9/h3-6,8H,7H2,1-2H3
  • InChiKey: ZOFHBKKGKAZUIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(4-chlorophenyl)-3-isopropyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
  • ZINC00112124
  • STK321285

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum importin beta, putative 0.0033 0.042 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1233 0.1931
Brugia malayi prolyl oligopeptidase family protein 0.0104 0.2536 0.3973
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1215 0.444
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0232 0.0312
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0093 0.2211 1
Entamoeba histolytica hypothetical protein 0.0027 0.0232 0.1961
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.6384 0.6384
Leishmania major hypothetical protein, conserved 0.0024 0.0162 0.0016
Schistosoma mansoni survival motor neuron protein 0.0047 0.0848 0.0848
Trypanosoma brucei prolyl oligopeptidase, putative 0.0041 0.0665 0.2131
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1215 0.4445
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1721 0.1721
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0536 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0158 0.0158
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1215 0.4445
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0536 0.0536
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0536 0.159
Loa Loa (eye worm) hypothetical protein 0.0033 0.042 0.042
Trypanosoma brucei prolyl endopeptidase 0.0104 0.2536 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1233 0.1233
Toxoplasma gondii prolyl endopeptidase 0.0104 0.2536 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0162 0.0016
Brugia malayi Inositol-1 0.0037 0.0536 0.084
Echinococcus granulosus importin subunit beta 1 0.0033 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0136 0.3513 0.3513
Brugia malayi TAR-binding protein 0.0076 0.1721 0.2695
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0232 0.1961
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0041 0.0665 0.2131
Loa Loa (eye worm) RNA binding protein 0.0076 0.1721 0.1721
Echinococcus granulosus tar DNA binding protein 0.0076 0.1721 0.1721
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.042 0.1099
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1215 1
Brugia malayi hypothetical protein 0.0232 0.6384 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0353 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1721 0.1721
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.042 0.1099
Brugia malayi RNA, U transporter 1 0.0094 0.2245 0.3517
Loa Loa (eye worm) hypothetical protein 0.006 0.1233 0.1233
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0536 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0162 0.0016
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0041 0.0665 1
Mycobacterium tuberculosis Probable peptidase 0.0041 0.0665 0.1366
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1721 0.1721
Schistosoma mansoni inositol monophosphatase 0.0037 0.0536 0.0536
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0162 0.0143
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0536 0.159
Loa Loa (eye worm) hypothetical protein 0.0136 0.3513 0.3513
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0848 0.1328
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0353 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.6384 0.6384
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0041 0.0665 0.1894
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0104 0.2536 0.2536
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0162 0.0143
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1721 0.1721
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.0158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1233 0.1931
Schistosoma mansoni ran 0.0024 0.0158 0.0158
Echinococcus granulosus prolyl endopeptidase 0.0104 0.2536 0.2536
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0232 0.1961
Onchocerca volvulus Huntingtin homolog 0.0136 0.3513 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2536 0.2536
Plasmodium vivax importin-beta 2, putative 0.0033 0.042 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1721 0.1721
Leishmania major importin beta-1 subunit, putative 0.0027 0.0232 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1721 0.1721
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0662 0.1037
Loa Loa (eye worm) inositol-1 0.0037 0.0536 0.0536
Leishmania major oligopeptidase b 0.0041 0.0665 0.2131
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1721 0.2695
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0232 0.1961
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0536 1
Echinococcus multilocularis importin subunit beta 1 0.0033 0.042 0.042
Brugia malayi Importin beta-1 subunit 0.0033 0.042 0.0657
Brugia malayi hypothetical protein 0.0136 0.3513 0.5503
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0162 0.0016
Brugia malayi RNA binding protein 0.0076 0.1721 0.2695
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0536 0.159
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.0248
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0158 0.0158
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.042 0.1099
Schistosoma mansoni hypothetical protein 0.0041 0.0662 0.0662
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0536 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0536 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1215 1
Onchocerca volvulus Huntingtin homolog 0.0136 0.3513 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0041 0.0665 0.2131
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0104 0.2536 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1215 0.1215
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0162 0.0143
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1215 0.1215
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0104 0.2536 0.2536
Loa Loa (eye worm) hypothetical protein 0.0024 0.0162 0.0162
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0162 0.0016
Trypanosoma cruzi oligopeptidase b 0.0041 0.0665 0.2131
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1215 0.1215
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0047 0.0848 0.0848
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0041 0.0665 0.1366
Echinococcus multilocularis prolyl endopeptidase 0.0104 0.2536 0.2536
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1721 0.1721
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0536 0.159
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1215 0.1215
Onchocerca volvulus Prolyl endopeptidase homolog 0.0104 0.2536 0.6335
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0041 0.0665 0.2131
Brugia malayi hypothetical protein 0.0024 0.0162 0.0254
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1721 0.1721
Echinococcus multilocularis snurportin 1 0.0353 1 1
Schistosoma mansoni ran 0.0024 0.0158 0.0158
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.6384 0.6384
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0536 0.159
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0041 0.0665 0.2131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0662 0.0662
Trypanosoma cruzi oligopeptidase b 0.0041 0.0665 0.2131
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1215 1
Schistosoma mansoni importin beta-1 0.0033 0.042 0.042
Trypanosoma brucei oligopeptidase b 0.0041 0.0665 0.2131
Trypanosoma cruzi prolyl endopeptidase 0.0104 0.2536 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.