Detailed information for compound 1478877

Basic information

Technical information
  • TDR Targets ID: 1478877
  • Name: 4-(chloromethyl)-2-(4-ethylphenyl)-1,3-thiazo le
  • MW: 237.748 | Formula: C12H12ClNS
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)c1scc(n1)CCl
  • InChi: 1S/C12H12ClNS/c1-2-9-3-5-10(6-4-9)12-14-11(7-13)8-15-12/h3-6,8H,2,7H2,1H3
  • InChiKey: LGPBFPAIFFOHBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(chloromethyl)-2-(4-ethylphenyl)thiazole
  • ZINC03349727

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0059 0.0398 0.2344
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.0288
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.1063
Chlamydia trachomatis pyruvate kinase 0.004 0.0205 0.3204
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0205 0.1205
Loa Loa (eye worm) latrophilin receptor protein 2 0.0243 0.2321 0.2598
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0175 0.1615 0.6957
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.1241
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0288 0.1697
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0288 0.0247
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0406 0.0406
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.1063
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0288 0.0713
Echinococcus multilocularis smad 0.006 0.0406 0.0406
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1615 0.3067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0083 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0178 0.1638 0.4234
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0623 0.1183
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0576 0.5797 1
Brugia malayi Latrophilin receptor protein 2 0.0243 0.2321 0.2552
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1788 0.4525
Loa Loa (eye worm) hypothetical protein 0.0183 0.1698 0.1898
Schistosoma mansoni patched 1 0.0051 0.0317 0.0601
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0243 0.2321 0.2552
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0062 0.0062
Plasmodium vivax ataxin-2 like protein, putative 0.0183 0.1698 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0083 0.001
Brugia malayi MH1 domain containing protein 0.0033 0.0128 0.0075
Brugia malayi MH1 domain containing protein 0.0033 0.0128 0.0075
Brugia malayi MH2 domain containing protein 0.0875 0.8914 1
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0319 0.0339
Leishmania major hypothetical protein, conserved 0.0178 0.1638 0.4434
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0576 0.5797 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0083 0.013
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0623 0.3667
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0288 0.0247
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.0288
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0243 0.2321 0.2321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0769 0.7802 0.8744
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0085
Brugia malayi hypothetical protein 0.0118 0.102 0.1082
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Echinococcus multilocularis pyruvate kinase 0.004 0.0205 0.0205
Echinococcus multilocularis Smad4 0.006 0.0406 0.0406
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0083 0.013
Schistosoma mansoni pyruvate kinase 0.004 0.0205 0.0389
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0623 0.0623
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0317 0.0317
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0406 0.0448
Brugia malayi MH2 domain containing protein 0.006 0.0406 0.0389
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0436 0.0685
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0334 0.0829
Echinococcus multilocularis expressed conserved protein 0.0112 0.0949 0.0949
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0238 0.1023
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0007 0.0044
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0288 0.0247
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0178 0.1638 0.4234
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0288 0.0585
Plasmodium vivax pyruvate kinase, putative 0.004 0.0205 0.1205
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0062 0.0062
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0406 0.0406
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0205 0.0161
Brugia malayi isocitrate dehydrogenase 0.0048 0.0288 0.0255
Loa Loa (eye worm) Smad1 0.006 0.0406 0.0448
Leishmania major pyruvate kinase 0.004 0.0205 0.0347
Loa Loa (eye worm) pyruvate kinase 0.004 0.0205 0.0221
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0576 0.5797 0.6478
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0406 0.1751
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.1698 0.4412
Toxoplasma gondii LsmAD domain-containing protein 0.0183 0.1698 1
Echinococcus granulosus pyruvate kinase 0.004 0.0205 0.0881
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0576 0.5797 1
Brugia malayi CHE-14 protein 0.0051 0.0317 0.0287
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0073 0.0431
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0077 0.0078
Loa Loa (eye worm) hypothetical protein 0.0186 0.172 0.1922
Loa Loa (eye worm) hypothetical protein 0.0062 0.0436 0.0481
Schistosoma mansoni hypothetical protein 0.0082 0.0643 0.122
Mycobacterium ulcerans hypothetical protein 0.0192 0.1788 0.3076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0769 0.7802 0.8751
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0082 0.0643 0.0643
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0073 0.0431
Schistosoma mansoni smad1 5 8 and 0.006 0.0406 0.0772
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0623 0.3667
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0023
Loa Loa (eye worm) pyruvate kinase 0.004 0.0205 0.0221
Brugia malayi Smad1 0.006 0.0406 0.0389
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.1698 0.4412
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0083 0.001
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0205 0.0248
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0082 0.0643 0.2768
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0043 0.0238 0.0451
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.013
Brugia malayi hypothetical protein 0.0043 0.0238 0.0198
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0576 0.5797 1
Schistosoma mansoni smad 0.006 0.0406 0.0772
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.1698 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0576 0.5797 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0243 0.2321 0.2321
Loa Loa (eye worm) hypothetical protein 0.0119 0.1025 0.1142
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1585 0.4079
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1025 0.1656
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1044 0.1983
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 1
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1557 0.1557
Mycobacterium ulcerans hypothetical protein 0.0029 0.0083 0.013
Echinococcus multilocularis pyruvate kinase 0.004 0.0205 0.0205
Brugia malayi MH1 domain containing protein 0.006 0.0406 0.0389
Plasmodium falciparum pyruvate kinase 0.004 0.0205 0.1205
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.1698 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0525 0.5265 0.5903
Loa Loa (eye worm) MH2 domain-containing protein 0.0875 0.8914 1
Echinococcus granulosus expressed conserved protein 0.0112 0.0949 0.409
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.013
Toxoplasma gondii hypothetical protein 0.0028 0.0073 0.0431
Loa Loa (eye worm) hypothetical protein 0.0243 0.2321 0.2598
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0023
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0317 0.1364
Mycobacterium ulcerans pyruvate kinase 0.004 0.0205 0.034
Brugia malayi map kinase activated protein kinase protein 2 0.0175 0.1615 0.1754
Echinococcus granulosus Smad4 0.006 0.0406 0.1751
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0085
Leishmania major pyruvate kinase 0.004 0.0205 0.0347
Loa Loa (eye worm) pyruvate kinase 0.004 0.0205 0.0221
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0205 0.0161
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0288 0.0255
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0083 0.0192
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Brugia malayi MH1 domain containing protein 0.006 0.0406 0.0389
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Onchocerca volvulus 0.0576 0.5797 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0623 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0317 0.02
Brugia malayi hypothetical protein 0.0183 0.1698 0.1848
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.008 0.0623 0.0691
Trypanosoma brucei PAB1-binding protein , putative 0.0183 0.1698 0.4412
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0576 0.5797 1
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0576 0.5797 0.65
Brugia malayi Probable ClpP-like protease 0.008 0.0623 0.0633
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0238 0.0238
Brugia malayi N-terminal motif family protein 0.0186 0.172 0.1872
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0205 0.0501
Echinococcus granulosus GPCR family 2 0.0243 0.2321 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0319 0.0339
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0288 0.0547
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1025 0.4414
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3589 1
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1557 0.6707
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0062 0.0062
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1585 0.4284
Echinococcus multilocularis GPCR, family 2 0.0243 0.2321 0.2321
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0317 0.0347
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1585 0.4079
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3589 1
Schistosoma mansoni smad 0.0027 0.0062 0.0118
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0319 0.0339
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0178 0.1638 0.2563
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0288 0.1697
Brugia malayi latrophilin 2 splice variant baaae 0.0525 0.5265 0.5878
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0192
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0007 0.0044
Giardia lamblia Pyruvate kinase 0.004 0.0205 0.0353
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0175 0.1615 0.1615
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0062 0.0269
Onchocerca volvulus 0.0029 0.0083 0.0036
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0062 0.0269
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0288 0.0288
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0623 0.3667
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1025 0.1087
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0238 0.0451
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0288 0.0315
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0062 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0288 0.1697
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0576 0.5797 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0078
Echinococcus multilocularis pyruvate kinase 0.0032 0.0116 0.0116
Schistosoma mansoni smad1 5 8 and 0.006 0.0406 0.0772
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0205 0.0248
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0576 0.5797 1
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0288 0.1697
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0623 0.2682
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0083 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3589 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0243 0.2321 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0347
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.3667
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0083 0.0179
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0576 0.5797 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0178 0.1638 0.2563
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0334 0.4744
Loa Loa (eye worm) nuclear factor I 0.0033 0.0128 0.0136
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3589 1
Echinococcus granulosus smad 0.006 0.0406 0.1751
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0319 0.0339
Schistosoma mansoni pyruvate kinase 0.004 0.0205 0.0389
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0175 0.1615 0.1805
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0136
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0205 0.2392
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0406 0.0772
Schistosoma mansoni Smad4 0.0027 0.0062 0.0118
Schistosoma mansoni smad1 5 8 and 0.006 0.0406 0.0772
Schistosoma mansoni hypothetical protein 0.0525 0.5265 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0406 0.1751
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0399 0.3943 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0334 0.0334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0243 0.2321 1
Schistosoma mansoni Smad4 0.006 0.0406 0.0772
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.0288
Echinococcus granulosus pyruvate kinase 0.004 0.0205 0.0881
Trypanosoma cruzi hypothetical protein, conserved 0.0178 0.1638 0.4234
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Schistosoma mansoni Smad4 0.0027 0.0062 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.013
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0317 0.1364
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0406 0.0448
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0334 0.0829
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1025 0.1025
Echinococcus multilocularis protein patched 0.0051 0.0317 0.0317
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0334 0.1438
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.0221
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0205 0.0248
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0576 0.5797 1
Brugia malayi MH2 domain containing protein 0.006 0.0406 0.0389
Leishmania major hypothetical protein, conserved 0.0183 0.1698 0.4606
Loa Loa (eye worm) transcription factor SMAD2 0.0875 0.8914 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0288 0.0247
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0023
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0083 0.013
Loa Loa (eye worm) hypothetical protein 0.0769 0.7802 0.8751
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.172 0.289
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0083 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0769 0.7802 0.8744

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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