Detailed information for compound 1478877

Basic information

Technical information
  • TDR Targets ID: 1478877
  • Name: 4-(chloromethyl)-2-(4-ethylphenyl)-1,3-thiazo le
  • MW: 237.748 | Formula: C12H12ClNS
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)c1scc(n1)CCl
  • InChi: 1S/C12H12ClNS/c1-2-9-3-5-10(6-4-9)12-14-11(7-13)8-15-12/h3-6,8H,2,7H2,1H3
  • InChiKey: LGPBFPAIFFOHBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(chloromethyl)-2-(4-ethylphenyl)thiazole
  • ZINC03349727

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad 0.006 0.0406 0.0772
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0406 0.1751
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0319 0.0339
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3589 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0288 0.0247
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1025 0.4414
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0082 0.0643 0.2768
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.1698 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0023
Leishmania major pyruvate kinase 0.004 0.0205 0.0347
Chlamydia trachomatis pyruvate kinase 0.004 0.0205 0.3204
Brugia malayi MH2 domain containing protein 0.006 0.0406 0.0389
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0062 0.0062
Schistosoma mansoni smad1 5 8 and 0.006 0.0406 0.0772
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0288 0.0247
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0576 0.5797 1
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0334 0.1438
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0406 0.0406
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0576 0.5797 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0334 0.0829
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0205 0.0161
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0077 0.0078
Echinococcus multilocularis GPCR, family 2 0.0243 0.2321 0.2321
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0623 0.3667
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.1241
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0082 0.0643 0.0643
Schistosoma mansoni Smad4 0.006 0.0406 0.0772
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0623 1
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0007 0.0044
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0576 0.5797 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0238 0.0238
Echinococcus multilocularis expressed conserved protein 0.0112 0.0949 0.0949
Loa Loa (eye worm) pyruvate kinase 0.004 0.0205 0.0221
Leishmania major hypothetical protein, conserved 0.0178 0.1638 0.4434
Echinococcus multilocularis pyruvate kinase 0.0032 0.0116 0.0116
Brugia malayi Latrophilin receptor protein 2 0.0243 0.2321 0.2552
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0406 0.0406
Brugia malayi Probable ClpP-like protease 0.008 0.0623 0.0633
Toxoplasma gondii hypothetical protein 0.0059 0.0398 0.2344
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.1063
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0576 0.5797 1
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3589 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1044 0.1983
Loa Loa (eye worm) hypothetical protein 0.0183 0.1698 0.1898
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Loa Loa (eye worm) pyruvate kinase 0.004 0.0205 0.0221
Brugia malayi MH1 domain containing protein 0.0033 0.0128 0.0075
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Loa Loa (eye worm) nuclear factor I 0.0033 0.0128 0.0136
Echinococcus multilocularis pyruvate kinase 0.004 0.0205 0.0205
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0406 0.0772
Schistosoma mansoni patched 1 0.0051 0.0317 0.0601
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0062 0.0062
Leishmania major pyruvate kinase 0.004 0.0205 0.0347
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0317 0.1364
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0334 0.0829
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1585 0.4079
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1025 0.1025
Echinococcus granulosus smad 0.006 0.0406 0.1751
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0319 0.0339
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0205 0.0248
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0085
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.1063
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Brugia malayi hypothetical protein 0.0043 0.0238 0.0198
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0288 0.0255
Plasmodium falciparum ataxin-2 like protein, putative 0.0183 0.1698 1
Schistosoma mansoni smad1 5 8 and 0.006 0.0406 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0317 0.02
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0576 0.5797 1
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0205 0.1205
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0243 0.2321 0.2598
Schistosoma mansoni pyruvate kinase 0.004 0.0205 0.0389
Schistosoma mansoni smad1 5 8 and 0.006 0.0406 0.0772
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Trypanosoma brucei PAB1-binding protein , putative 0.0183 0.1698 0.4412
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1557 0.6707
Entamoeba histolytica hypothetical protein 0.0043 0.0238 0.028
Brugia malayi CHE-14 protein 0.0051 0.0317 0.0287
Brugia malayi MH1 domain containing protein 0.006 0.0406 0.0389
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0288 0.1697
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0062 0.0062
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0083 0.0179
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0083 0.013
Echinococcus granulosus expressed conserved protein 0.0112 0.0949 0.409
Schistosoma mansoni Smad4 0.0027 0.0062 0.0118
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0136
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1585 0.4284
Toxoplasma gondii LsmAD domain-containing protein 0.0183 0.1698 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0205 0.0221
Leishmania major hypothetical protein, conserved 0.0183 0.1698 0.4606
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.3667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0083 0.0192
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0769 0.7802 0.8751
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0576 0.5797 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0083 0.013
Echinococcus granulosus pyruvate kinase 0.004 0.0205 0.0881
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0623 0.1183
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.1698 0.4412
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0205 0.0248
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0317 0.1364
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0083 0.013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0083 0.001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0623 0.3667
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.0288
Schistosoma mansoni hypothetical protein 0.0049 0.0297 0.0565
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0406 0.1751
Brugia malayi hypothetical protein 0.0118 0.102 0.1082
Loa Loa (eye worm) hypothetical protein 0.0243 0.2321 0.2598
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.0221
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0319 0.0339
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0288 0.1697
Loa Loa (eye worm) transcription factor SMAD2 0.0875 0.8914 1
Trypanosoma cruzi hypothetical protein, conserved 0.0178 0.1638 0.4234
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0085
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0317 0.0347
Schistosoma mansoni hypothetical protein 0.0243 0.2321 0.4409
Schistosoma mansoni hypothetical protein 0.0525 0.5265 1
Brugia malayi latrophilin 2 splice variant baaae 0.0525 0.5265 0.5878
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0083 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0243 0.2321 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0175 0.1615 0.1805
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.1615 0.3067
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.013
Loa Loa (eye worm) hypothetical protein 0.0186 0.172 0.1922
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0288 0.0547
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0085
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0288 0.0288
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0576 0.5797 1
Loa Loa (eye worm) hypothetical protein 0.0525 0.5265 0.5903
Brugia malayi map kinase activated protein kinase protein 2 0.0175 0.1615 0.1754
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.172 0.289
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0175 0.1615 0.1615
Brugia malayi MH2 domain containing protein 0.006 0.0406 0.0389
Trypanosoma cruzi PAB1-binding protein , putative 0.0183 0.1698 0.4412
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0175 0.1615 0.6957
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0178 0.1638 0.4234
Onchocerca volvulus 0.0029 0.0083 0.0036
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0062 0.0269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0769 0.7802 0.8744
Echinococcus multilocularis protein patched 0.0051 0.0317 0.0317
Echinococcus multilocularis protein dispatched 1 0.0058 0.0392 0.0392
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0319 0.0339
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0205 0.0248
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0288 0.1697
Schistosoma mansoni smad 0.0027 0.0062 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0406 0.0448
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0436 0.0685
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0243 0.2321 1
Echinococcus granulosus Smad4 0.006 0.0406 0.1751
Brugia malayi isocitrate dehydrogenase 0.0048 0.0288 0.0255
Loa Loa (eye worm) hypothetical protein 0.0119 0.1025 0.1142
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0073 0.0431
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1585 0.4079
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.013
Schistosoma mansoni Smad4 0.0027 0.0062 0.0118
Plasmodium falciparum pyruvate kinase 0.004 0.0205 0.1205
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0083 0.013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0334 0.4744
Mycobacterium ulcerans hypothetical protein 0.0192 0.1788 0.3076
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1025 0.1656
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0205 0.2392
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0205 0.0161
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0023
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0406 0.0448
Mycobacterium ulcerans hypothetical protein 0.0029 0.0083 0.013
Schistosoma mansoni hypothetical protein 0.0082 0.0643 0.122
Loa Loa (eye worm) Smad1 0.006 0.0406 0.0448
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0238 0.0451
Echinococcus granulosus GPCR family 2 0.0243 0.2321 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0238 0.1023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0243 0.2321 0.2321
Loa Loa (eye worm) hypothetical protein 0.008 0.0623 0.0691
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0178 0.1638 0.2563
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0288 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1788 0.4525
Brugia malayi MH2 domain containing protein 0.0875 0.8914 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0243 0.2321 0.2321
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0399 0.3943 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0623 0.2682
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0769 0.7802 0.8744
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0243 0.2321 0.2552
Brugia malayi N-terminal motif family protein 0.0186 0.172 0.1872
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0623 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0073 0.0431
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0178 0.1638 0.2563
Giardia lamblia Pyruvate kinase 0.004 0.0205 0.0353
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0062 0.0269
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0007 0.0044
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0576 0.5797 0.65
Loa Loa (eye worm) hypothetical protein 0.0062 0.0436 0.0481
Brugia malayi Smad1 0.006 0.0406 0.0389
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0317 0.0317
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0576 0.5797 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0083 0.001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0288 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.0178 0.1638 0.4234
Loa Loa (eye worm) hypothetical protein 0.0769 0.7802 0.8751
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0083 0.0192
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0288 0.1697
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0576 0.5797 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0875 0.8914 1
Brugia malayi MH1 domain containing protein 0.006 0.0406 0.0389
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.0288
Brugia malayi MH1 domain containing protein 0.0033 0.0128 0.0075
Plasmodium vivax pyruvate kinase, putative 0.004 0.0205 0.1205
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0083 0.0023
Mycobacterium ulcerans pyruvate kinase 0.004 0.0205 0.034
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0083 0.001
Schistosoma mansoni hypothetical protein 0.0043 0.0238 0.0451
Echinococcus multilocularis Smad4 0.006 0.0406 0.0406
Echinococcus multilocularis smad 0.006 0.0406 0.0406
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3589 1
Echinococcus granulosus pyruvate kinase 0.004 0.0205 0.0881
Brugia malayi hypothetical protein 0.0183 0.1698 0.1848
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0083 0.0179
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0288 0.0585
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0288 0.0247
Schistosoma mansoni pyruvate kinase 0.004 0.0205 0.0389
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0205 0.0501
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.0062
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0623 0.3667
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0576 0.5797 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3589 1
Toxoplasma gondii hypothetical protein 0.0028 0.0073 0.0431
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.0347
Echinococcus multilocularis pyruvate kinase 0.004 0.0205 0.0205
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0062 0.0062
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0576 0.5797 0.6478
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0288 0.0713
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0623 0.0623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0288 0.0288
Onchocerca volvulus 0.0576 0.5797 1
Plasmodium vivax ataxin-2 like protein, putative 0.0183 0.1698 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1025 0.1087
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0334 0.0334

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.