Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0164 | 0.0499 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0164 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0008 | 0.0018 | 0.0054 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0164 | 0.0146 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0164 | 0.0146 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3285 | 0.3273 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0164 | 0.0499 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor | 0.0008 | 0.0018 | 0.0054 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3285 | 0.3273 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0.0018 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5002 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.