Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0417 | 1 | 1 |
Schistosoma mansoni | casein kinase II beta subunit | 0.0303 | 0.4623 | 0.4623 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0417 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0417 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0417 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0417 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0417 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0417 | 1 | 1 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0303 | 0.4623 | 0.5 |
Onchocerca volvulus | Casein kinase II subunit beta homolog | 0.0303 | 0.4623 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0417 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit beta | 0.0303 | 0.4623 | 0.4623 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0417 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0417 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0417 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0417 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit beta | 0.0303 | 0.4623 | 0.4623 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0417 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0417 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0417 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34 % | Displacement [3H]-CGS-21,680 from Adenosine A2A receptor in rat striatal membrane | ChEMBL. | 8558508 |
Ki (binding) | = 0.567 uM | Tested for the displacement [3H]-PIA from Adenosine A1 receptor in rat brain membrane | ChEMBL. | 8558508 |
Potency (functional) | 5.1735 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.