Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0068 | 0.0618 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0201 | 0.4785 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0233 | 0.0241 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0068 | 0.0618 | 0.0846 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0201 | 0.4785 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0368 | 1 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0201 | 0.4785 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0068 | 0.0618 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0201 | 0.4785 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0068 | 0.0618 | 0.0846 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0068 | 0.0618 | 0.1067 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0068 | 0.0618 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0368 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0233 | 0.0241 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0068 | 0.0618 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0068 | 0.0618 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0201 | 0.4785 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0368 | 1 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0201 | 0.4785 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0068 | 0.0618 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0368 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0368 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0068 | 0.0618 | 0.0846 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0368 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.