Detailed information for compound 1487590

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1661.99 | Formula: C67H124N34O14S
  • H donors: 29 H acceptors: 14 LogP: -9.96 Rotable bonds: 78
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CS)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCC(=O)N)CCCNC(=N)N)CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(cc1)O)N)CCCNC(=N)N)CCCCN
  • InChi: 1S/C67H124N34O14S/c68-25-3-1-11-40(93-53(107)39(13-5-27-85-62(73)74)92-50(104)34-91-52(106)38(70)33-36-19-21-37(102)22-20-36)54(108)94-41(12-2-4-26-69)55(109)95-42(14-6-28-86-63(75)76)56(110)97-45(17-9-31-89-66(81)82)59(113)100-47(23-24-49(71)103)61(115)99-44(16-8-30-88-65(79)80)58(112)96-43(15-7-29-87-64(77)78)57(111)98-46(18-10-32-90-67(83)84)60(114)101-48(35-116)51(72)105/h19-22,38-48,102,116H,1-18,23-35,68-70H2,(H2,71,103)(H2,72,105)(H,91,106)(H,92,104)(H,93,107)(H,94,108)(H,95,109)(H,96,112)(H,97,110)(H,98,111)(H,99,115)(H,100,113)(H,101,114)(H4,73,74,85)(H4,75,76,86)(H4,77,78,87)(H4,79,80,88)(H4,81,82,89)(H4,83,84,90)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1
  • InChiKey: DLTIMGFUZUCMCF-AIFXSXIMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0072 0.0228 0.0188
Echinococcus granulosus neuroendocrine convertase 2 0.0105 0.0416 0.0376
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0072 0.0228 0.0188
Schistosoma mansoni calcium-activated potassium channel 0.0072 0.0228 0.0228
Echinococcus multilocularis twik family of potassium channels 0.0072 0.0228 0.0188
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0228 0.5755
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0072 0.0228 0.116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0078 0.0078
Loa Loa (eye worm) choline/ethanolamine kinase 0.0079 0.027 0.023
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0078 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0082 0.0041
Echinococcus multilocularis potassium channel subfamily K 8 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0072 0.0228 0.116
Onchocerca volvulus 0.0072 0.0228 1
Echinococcus multilocularis 0.0134 0.0586 0.0547
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0162 0.0162
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Echinococcus multilocularis small conductance calcium activated potassium 0.1775 1 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0072 0.0228 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0228 0.5755
Echinococcus granulosus acetylcholinesterase 0.0271 0.137 0.1335
Plasmodium vivax choline kinase, putative 0.0079 0.027 1
Echinococcus multilocularis acetylcholinesterase 0.0271 0.137 0.1335
Echinococcus granulosus calcium activated potassium channel variant 0.0072 0.0228 0.0188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0041 0.1032
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0101 0.0396 0.0357
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Giardia lamblia Hypothetical protein 0.0072 0.0228 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0271 0.137 0.137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0041 0.1032
Echinococcus granulosus choline:ethanolamine kinase 0.0079 0.027 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0192 0.6899
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis carboxylesterase 5A 0.0271 0.137 0.1335
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0228 0.5755
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0228 0.5755
Brugia malayi hypothetical protein 0.0072 0.0228 0.116
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.074 0.4059 0.4034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0072 0.0228 0.116
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0072 0.0228 0.116
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0162 0.0162
Trypanosoma cruzi ion transport protein, putative 0.0072 0.0228 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0072 0.0228 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0078 0.1968
Schistosoma mansoni gliotactin 0.0046 0.0078 0.0078
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0041 0.1032
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0141 0.0101
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0072 0.0228 0.116
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0162 0.0122
Schistosoma mansoni hypothetical protein 0.0072 0.0228 0.0228
Brugia malayi endoprotease bli-4 precursor 0.0167 0.0771 0.5361
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0078 0.0037
Echinococcus granulosus potassium channel subfamily K 0.0072 0.0228 0.0188
Echinococcus granulosus potassium channel subfamily K 8 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0041 0.1032
Echinococcus multilocularis neuroligin 0.0046 0.0078 0.0037
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0078 0.1968
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) endoprotease bli-4 0.0167 0.0771 0.0733
Loa Loa (eye worm) hypothetical protein 0.0664 0.3624 0.3597
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0078 0.0037
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0072 0.0228 0.116
Echinococcus granulosus acetylcholinesterase 0.0271 0.137 0.1335
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0192 0.6899
Brugia malayi Carboxylesterase family protein 0.0271 0.137 1
Echinococcus granulosus potassium channel subfamily K 8 0.0072 0.0228 0.0188
Loa Loa (eye worm) uncoordinated protein 58 0.0072 0.0228 0.0188
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0072 0.0228 0.0188
Onchocerca volvulus 0.0072 0.0228 1
Brugia malayi celfurPC protein 0.0134 0.0586 0.3931
Loa Loa (eye worm) hypothetical protein 0.0065 0.019 0.015
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0072 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Plasmodium falciparum choline kinase 0.0079 0.027 1
Echinococcus multilocularis acetylcholinesterase 0.0271 0.137 0.1335
Brugia malayi proprotein convertase 2 0.0105 0.0416 0.2613
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Schistosoma mansoni calcium-activated potassium channel 0.1775 1 1
Onchocerca volvulus 0.0072 0.0228 1
Schistosoma mansoni calcium-activated potassium channel 0.1404 0.7867 0.7867
Brugia malayi Choline/ethanolamine kinase family protein 0.0079 0.027 0.1483
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0101 0.0396 0.0357
Loa Loa (eye worm) TWK-7 protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0072 0.0228 0.0188
Brugia malayi Cytochrome P450 family protein 0.0047 0.0082 0.0033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus granulosus microtubule associated protein 2 0.071 0.3887 0.3862
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0072 0.0228 0.116
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0072 0.0228 0.116
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0041 0.1032
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0072 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.137 0.1335
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0192 0.6899
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.1775 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.1775 1 1
Schistosoma mansoni microtubule-associated protein tau 0.071 0.3887 0.3887
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0072 0.0228 0.116
Leishmania major ion transport protein-like protein 0.0072 0.0228 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0078 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus granulosus carboxylesterase 5A 0.0271 0.137 0.1335
Onchocerca volvulus 0.0072 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Echinococcus multilocularis calcium activated potassium channel variant 0.0072 0.0228 0.0188
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0162 0.0122
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) carboxylesterase 0.0046 0.0078 0.0037
Brugia malayi neuroendocrine convertase 1 precursor 0.0105 0.0416 0.2613
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Brugia malayi hypothetical protein 0.0072 0.0228 0.116
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0167 0.0771 0.0733
Loa Loa (eye worm) carboxylesterase 0.0271 0.137 0.1335
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0072 0.0228 0.0188
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0228 0.5755
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0072 0.0228 0.0188
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0159 0.4102
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0078 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0162 0.0122
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Schistosoma mansoni acetylcholinesterase 0.0046 0.0078 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0228 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0072 0.0228 0.116
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0162 0.0122
Onchocerca volvulus 0.0072 0.0228 1
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0101 0.0396 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0072 0.0228 0.116
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0072 0.0228 0.5
Echinococcus multilocularis potassium channel subfamily K 0.0072 0.0228 0.0188
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0228 1
Echinococcus granulosus furin 0.0167 0.0771 0.0733
Leishmania major hypothetical protein, conserved 0.0072 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Onchocerca volvulus 0.0072 0.0228 1
Loa Loa (eye worm) carboxylesterase 0.0046 0.0078 0.0037
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0141 0.0101
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0072 0.0228 0.116
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0072 0.0228 0.116
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0072 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0072 0.0228 0.116
Loa Loa (eye worm) hypothetical protein 0.03 0.1535 0.1501
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0271 0.137 0.1335
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Toxoplasma gondii phosphotransferase enzyme family protein 0.0079 0.027 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0192 0.6899
Onchocerca volvulus 0.0072 0.0228 1
Schistosoma mansoni furin-1 (S08 family) 0.0072 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0072 0.0228 0.116
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0039 0.0041 0.0041
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0072 0.0228 1
Leishmania major hypothetical protein, conserved 0.0072 0.0228 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0105 0.0416 0.0376
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0078 0.0037
Loa Loa (eye worm) TWK-28 protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis microtubule associated protein 2 0.071 0.3887 0.3862
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Onchocerca volvulus 0.0072 0.0228 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0078 0.0037
Loa Loa (eye worm) acetylcholinesterase 1 0.0271 0.137 0.1335
Echinococcus granulosus twik family of potassium channels 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0162 0.0122
Leishmania major calcium/potassium channel (CAKC), putative 0.0072 0.0228 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Trypanosoma cruzi ion transport protein, putative 0.0072 0.0228 1
Echinococcus multilocularis potassium channel subfamily K 8 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Echinococcus multilocularis choline:ethanolamine kinase 0.0079 0.027 0.023
Echinococcus granulosus neuroligin 0.0046 0.0078 0.0037
Mycobacterium ulcerans transmembrane cation transporter 0.0072 0.0228 1
Trypanosoma brucei calcium-activated potassium channel, putative 0.0072 0.0228 1
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0072 0.0228 0.116
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Schistosoma mansoni lipoxygenase 0.0057 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Schistosoma mansoni twik family of potassium channels-related 0.0072 0.0228 0.0228
Echinococcus multilocularis twik family of potassium channels 0.0072 0.0228 0.0188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0039 0.0041 0.1032
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0101 0.0396 1
Echinococcus granulosus twik family of potassium channels 0.0072 0.0228 0.0188
Brugia malayi jmjC domain containing protein 0.0061 0.0162 0.0652
Schistosoma mansoni calcium-activated potassium channel 0.0072 0.0228 0.0228
Brugia malayi Carboxylesterase family protein 0.0271 0.137 1
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0072 0.0228 0.0188
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0072 0.0228 0.116
Giardia lamblia High cysteine membrane protein Group 2 0.0062 0.017 0.7472
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0167 0.0771 0.0771
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0188
Leishmania major potassium channel subunit-like protein 0.0072 0.0228 1
Mycobacterium ulcerans ion transport protein 0.0072 0.0228 1
Brugia malayi jmjC domain containing protein 0.0061 0.0162 0.0652

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as inhibition of fungal growth at 6.25 uM after 48 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 0 % Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as inhibition of fungal growth at 12.5 uM after 48 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 1.75 % Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as inhibition of fungal growth at 25 uM after 48 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 4.97 % Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of fungal growth at 6.25 uM after 24 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 6.12 % Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of fungal growth at 12.5 uM after 24 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 6.71 % Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of fungal growth at 25 uM after 24 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 6.75 % Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of fungal growth at 50 uM after 24 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 61.3 % Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as inhibition of fungal growth at 50 uM after 48 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 99.08 % Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of fungal growth at 200 uM after 24 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 99.1 % Antifungal activity against Candida albicans ATCC 10231 assessed as inhibition of fungal growth at 100 uM after 24 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 100 % Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as inhibition of fungal growth at 100 uM after 48 hrs by microplate analysis ChEMBL. 21093119
Inhibition (functional) = 100 % Antifungal activity against Cryptococcus neoformans ATCC 32264 assessed as inhibition of fungal growth at 200 uM after 48 hrs by microplate analysis ChEMBL. 21093119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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