TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.311 | Formula: C22H19Cl2N3O2
H donors: 1 H acceptors: 2 LogP: 4.1 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CC(=O)N2[C@H](C1=O)Cc1c([C@@H]2c2ccc(cc2Cl)Cl)[nH]c2c1cccc2
InChi: 1S/C22H19Cl2N3O2/c1-2-26-11-19(28)27-18(22(26)29)10-15-13-5-3-4-6-17(13)25-20(15)21(27)14-8-7-12(23)9-16(14)24/h3-9,18,21,25H,2,10-11H2,1H3/t18-,21-/m0/s1
InChiKey: PFUKSWGPHRDSII-RXVVDRJESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	geminin	0.0353	0.1273	0.1273
Echinococcus granulosus	sex peptide receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	geminin	0.0353	0.1273	0.1273
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0783	0.3021	0.3021
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0066	0.011	0.04
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0066	0.011	0.011
Brugia malayi	GnHR receptor homolog	0.0205	0.0672	0.2519
Echinococcus granulosus	neuropeptide Y receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	opsin-like receptor	0.0205	0.0672	0.0672
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0218	0.0725	0.0725
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	hypothetical protein	0.0045	0.0021	0.0021
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0205	0.0672	0.0672
Mycobacterium leprae	conserved hypothetical protein	0.0047	0.0031	0.5
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.0028	0.0093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Echinococcus granulosus	7tm_1 domain containing protein	0.0205	0.0672	0.0672
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0205	0.0672	0.2511
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Echinococcus granulosus	neuropeptide FF receptor 2	0.0696	0.2669	0.2669
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Brugia malayi	proprotein convertase 2	0.0107	0.0274	0.1027
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0205	0.0672	0.0672
Schistosoma mansoni	patched 1	0.0046	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0205	0.0672	0.0672
Loa Loa (eye worm)	G-protein coupled receptor	0.0205	0.0672	0.2511
Schistosoma mansoni	neuropeptide F-like receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	neuropeptide receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	neuropeptide Y receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	Niemann Pick C1 protein	0.0108	0.0278	0.0278
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	small conductance calcium activated potassium	0.019	0.0611	0.0611
Brugia malayi	follicle stimulating hormone receptor	0.0205	0.0672	0.2519
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0065	0.0104	0.0391
Echinococcus granulosus	hypothetical protein	0.0205	0.0672	0.0672
Onchocerca volvulus		0.0093	0.0218	0.1923
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0205	0.0672	0.0672
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0109	0.0285	0.0285
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Schistosoma mansoni	protein kinase	0.0066	0.011	0.011
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0205	0.0672	0.0672
Echinococcus multilocularis	dro:myosuppressin receptor	0.0205	0.0672	0.0672
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0218	0.0725	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Schistosoma mansoni	glutamate receptor kainate	0.0717	0.2751	0.2751
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0496	0.1855	0.1855
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0205	0.0672	0.0672
Echinococcus granulosus	allatostatin A receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0065	0.0104	0.0104
Echinococcus granulosus	fmrfamide receptor	0.0205	0.0672	0.0672
Onchocerca volvulus		0.0205	0.0672	1
Loa Loa (eye worm)	glutamate receptor 1	0.0438	0.1621	0.6069
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0066	0.011	0.0411
Schistosoma mansoni	neuropeptide receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0147	0.0439	0.0439
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0783	0.3021	0.3021
Echinococcus granulosus	neuropeptides capa receptor	0.0205	0.0672	0.0672
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0075	0.0271
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.01	0.0248	0.297
Echinococcus granulosus	tm gpcr rhodopsin	0.0205	0.0672	0.0672
Echinococcus granulosus	tyrosine kinase	0.0066	0.011	0.011
Echinococcus multilocularis	Niemann Pick C1 protein	0.0154	0.0466	0.0466
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0066	0.011	0.011
Schistosoma mansoni	calcium-activated potassium channel	0.0122	0.0337	0.0337
Onchocerca volvulus		0.0205	0.0672	1
Brugia malayi	Melatonin receptor type 1A	0.0205	0.0672	0.2519
Brugia malayi	neuropeptide F receptor	0.0205	0.0672	0.2519
Echinococcus multilocularis	Furin 1	0.004	0.0003	0.0003
Brugia malayi	CAAX amino terminal protease family protein	0.0181	0.0575	0.2154
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0505	0.1891	0.1891
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Schistosoma mansoni	metabotropic glutamate receptor	0.0066	0.011	0.011
Echinococcus multilocularis	allatostatin A receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	glutamate receptor 4	0.0088	0.0199	0.0199
Echinococcus granulosus	somatostatin receptor	0.0205	0.0672	0.0672
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0065	0.0104	0.1769
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0108	0.0278	0.4832
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	CAAX prenyl protease 2	0.0181	0.0575	0.0575
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0783	0.3021	0.3021
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0111	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0147	0.0439	0.0439
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0181	0.0575	0.0575
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0147	0.0439	0.7069
Brugia malayi	putative neuropeptide receptor	0.0205	0.0672	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0783	0.3021	0.3021
Echinococcus multilocularis	g protein coupled receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.004	0.0003	0.0003
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	Niemann Pick C1 protein	0.0108	0.0278	0.0278
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Brugia malayi	sulfakinin receptor protein	0.0205	0.0672	0.2519
Echinococcus multilocularis	serotonin receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0205	0.0672	0.0672
Schistosoma mansoni	amine GPCR	0.0205	0.0672	0.0672
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus multilocularis	neuropeptide receptor A26	0.0205	0.0672	0.0672
Brugia malayi	G-protein coupled receptor	0.0205	0.0672	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	neuroendocrine convertase 2	0.0107	0.0274	0.0274
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0496	0.1855	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Onchocerca volvulus		0.0205	0.0672	1
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus multilocularis	somatostatin receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	amine GPCR	0.0205	0.0672	0.0672
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0783	0.3021	0.3021
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0047	0.0031	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0696	0.2669	1
Echinococcus granulosus	glutamate receptor 2	0.0375	0.1365	0.1365
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0066	0.011	0.0411
Echinococcus granulosus	neuropeptide receptor A26	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0057	0.007	0.0252
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0205	0.0672	0.2511
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Brugia malayi	AKH receptor	0.0205	0.0672	0.2519
Echinococcus granulosus	glutamate receptor 1	0.0088	0.0199	0.0199
Echinococcus multilocularis	g-protein coupled receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	glutamate NMDA receptor subunit	0.035	0.1262	0.1262
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0365	0.6329
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0205	0.0672	0.0672
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	nmda type glutamate receptor	0.0066	0.011	0.011
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0205	0.0672	0.0672
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0205	0.0672	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Schistosoma mansoni	hypothetical protein	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0088	0.0318
Brugia malayi	Dopamine receptor protein 2	0.0205	0.0672	0.2519
Brugia malayi	celfurPC protein	0.0137	0.0397	0.1488
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	TYRA-2 protein	0.0205	0.0672	0.2511
Onchocerca volvulus		0.0205	0.0672	1
Schistosoma mansoni	amine GPCR	0.0205	0.0672	0.0672
Schistosoma mansoni	hypothetical protein	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	G protein coupled receptor 139	0.0205	0.0672	0.0672
Echinococcus granulosus	biogenic amine 5HT receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	glutamate receptor 2	0.035	0.1262	0.4722
Schistosoma mansoni	glutamate receptor kainate	0.035	0.1262	0.1262
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0205	0.0672	0.0672
Schistosoma mansoni	amine GPCR	0.0205	0.0672	0.0672
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.035	0.1262	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Schistosoma mansoni	hypothetical protein	0.0205	0.0672	0.0672
Echinococcus granulosus	g protein coupled receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0088	0.0088
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	amine GPCR	0.0205	0.0672	0.0672
Brugia malayi	neuropeptide F receptor	0.0205	0.0672	0.2519
Schistosoma mansoni	glutamate receptor NMDA	0.0416	0.1532	0.1532
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0575	0.2145
Schistosoma mansoni	biogenic amine receptor	0.0205	0.0672	0.0672
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	calcium-activated potassium channel	0.019	0.0611	0.0611
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0205	0.0672	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0205	0.0672	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0205	0.0672	0.2519
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.004	0.015
Schistosoma mansoni	growth hormone secretagogue receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	neuropeptides capa receptor	0.0205	0.0672	0.0672
Brugia malayi	Receptor family ligand binding region containing protein	0.0066	0.011	0.0411
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0218	0.0806
Echinococcus multilocularis	neuropeptides capa receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	neuropeptide s receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.013	0.0366	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	melatonin receptor type 1A	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.01	0.0248	0.4281
Schistosoma mansoni	neuropeptide receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0181	0.0575	0.0575
Echinococcus multilocularis	glutamate receptor 2	0.0438	0.1621	0.1621
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.0028	0.0028
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Brugia malayi	Receptor family ligand binding region containing protein	0.0066	0.011	0.0411
Echinococcus multilocularis	g protein coupled receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0061	0.0061
Onchocerca volvulus		0.0205	0.0672	1
Onchocerca volvulus		0.0205	0.0672	1
Schistosoma mansoni	opsin-like receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0505	0.1891	0.1891
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Onchocerca volvulus		0.0205	0.0672	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0065	0.0104	0.1769
Brugia malayi	putative neuropeptide receptor NPR1	0.0205	0.0672	0.2519
Echinococcus multilocularis	neuropeptide Y receptor	0.0205	0.0672	0.0672
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0199	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0028	0.0093
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0066	0.011	0.011
Schistosoma mansoni	histamine h1 receptor	0.0205	0.0672	0.0672
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Brugia malayi	CHE-14 protein	0.0046	0.0028	0.0105
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0103	0.026	0.4487
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Onchocerca volvulus		0.0205	0.0672	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0205	0.0672	0.2519
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0054	0.0054
Loa Loa (eye worm)	neuropeptide F receptor	0.0205	0.0672	0.2511
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0066	0.011	0.04
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	dro:myosuppressin receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	G protein coupled receptor 139	0.2501	1	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0205	0.0672	0.0672
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0093	0.0218	0.0218
Schistosoma mansoni	neuropeptide receptor	0.2501	1	1
Echinococcus granulosus	g protein coupled receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	expressed conserved protein	0.0101	0.0251	0.0251
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0103	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Brugia malayi	neuroendocrine convertase 1 precursor	0.0107	0.0274	0.1027
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0066	0.011	0.011
Echinococcus granulosus	biogenic amine 5HT receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis		0.0137	0.0397	0.0397
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.013	0.0366	0.0366
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Brugia malayi	Guanylyl cyclase protein 23	0.0066	0.011	0.0411
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Brugia malayi	Bromodomain containing protein	0.0077	0.0152	0.0569
Schistosoma mansoni	metabotropic glutamate receptor	0.0066	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0278	0.1031
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0205	0.0672	0.0672
Schistosoma mansoni	glutamate receptor kainate	0.0717	0.2751	0.2751
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0496	0.1855	0.1855
Brugia malayi	Dopamine receptor	0.0205	0.0672	0.2519
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	glutamate receptor NMDA	0.035	0.1262	0.1262
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0205	0.0672	0.0672
Loa Loa (eye worm)	neuropeptide F receptor	0.0205	0.0672	0.2511
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus granulosus	nmda type glutamate receptor	0.013	0.0366	0.0366
Echinococcus multilocularis	NMDA receptor	0.0496	0.1855	0.1855
Echinococcus granulosus	Niemann Pick C1 protein	0.0154	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0199	0.0735
Schistosoma mansoni	hypothetical protein	0.019	0.0611	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0218	0.0806
Echinococcus multilocularis	g protein coupled receptor	0.0205	0.0672	0.0672
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0147	0.0439	0.7069
Brugia malayi	Serotonin receptor	0.0205	0.0672	0.2519
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0066	0.011	0.011
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0066	0.011	0.04
Loa Loa (eye worm)	glutamate receptor	0.0066	0.011	0.04
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0028	0.0434
Echinococcus multilocularis	expressed conserved protein	0.0101	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0102	0.0372
Echinococcus multilocularis	neuropeptides capa receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	lipoxygenase	0.0054	0.0061	0.0061
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0181	0.0575	1
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0696	0.2669	0.2669
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Echinococcus granulosus	neuropeptide receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0103	0.0103
Echinococcus granulosus	7TM GPCR rhodopsin	0.0205	0.0672	0.0672
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	endoprotease bli-4	0.017	0.0531	0.1979
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.0028	0.0028
Brugia malayi	Niemann-Pick C1 protein precursor	0.0108	0.0278	0.1041
Brugia malayi	metabotropic glutamate receptor type 2	0.0066	0.011	0.0411
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0205	0.0672	0.0672
Schistosoma mansoni	tyrosine kinase	0.0066	0.011	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0031	0.0483
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0205	0.0672	0.0672
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Schistosoma mansoni	biogenic amine receptor	0.0205	0.0672	0.0672
Brugia malayi	Serotonin receptor	0.0205	0.0672	0.2519
Brugia malayi	larval opioid receptor	0.0205	0.0672	0.2519
Giardia lamblia	Hypothetical protein	0.0181	0.0575	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0066	0.011	0.011
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	Furin 1	0.004	0.0003	0.0003
Brugia malayi	G-protein coupled receptor	0.0205	0.0672	0.2519
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0065	0.0104	0.1769
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0365	0.6329
Onchocerca volvulus		0.0205	0.0672	1
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0066	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0066	0.011	0.011
Schistosoma mansoni	biogenic amine receptor	0.0205	0.0672	0.0672
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0181	0.0575	1
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0103	0.026	0.026
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0205	0.0672	0.0672
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	glutamate receptor AMPA	0.035	0.1262	0.1262
Onchocerca volvulus		0.0205	0.0672	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0205	0.0672	0.2519
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.0796	1
Loa Loa (eye worm)	hypothetical protein	0.019	0.0611	0.228
Echinococcus granulosus	g protein coupled receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Onchocerca volvulus		0.0087	0.0193	0.1485
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.004	0.015
Echinococcus granulosus	g-protein coupled receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0049	0.004	0.0138
Schistosoma mansoni	neuropeptide F-like receptor	0.0205	0.0672	0.0672
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.1674	0.6639	1
Schistosoma mansoni	hypothetical protein	0.013	0.0366	0.0366
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus granulosus	receptor type guanylyl cyclase	0.0066	0.011	0.011
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	tyrosine kinase	0.0066	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0199	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0439	0.7615
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0147	0.0439	0.7069
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.017	0.0531	0.1979
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0205	0.0672	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Echinococcus multilocularis	glutamate receptor 2	0.0375	0.1365	0.1365
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0103	0.026	0.4487
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Plasmodium vivax	hypothetical protein, conserved	0.0047	0.0031	0.5
Echinococcus granulosus	expressed protein	0.0409	0.15	0.15
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0205	0.0672	0.0672
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0065	0.0104	0.0104
Schistosoma mansoni	furin-1 (S08 family)	0.0074	0.014	0.014
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0147	0.0439	0.7615
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0181	0.0575	1
Echinococcus multilocularis	orexin receptor type 2	0.0205	0.0672	0.0672
Schistosoma mansoni	adenoreceptor	0.0205	0.0672	0.0672
Echinococcus granulosus	serotonin receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	glutamate receptor 2	0.0505	0.1891	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Brugia malayi	ORL1-like opioid receptor	0.0205	0.0672	0.2519
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus granulosus	neuroendocrine convertase 2	0.0107	0.0274	0.0274
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0205	0.0672	0.2511
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0365	0.6329
Echinococcus multilocularis	fmrfamide receptor	0.0205	0.0672	0.0672
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.0031	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0205	0.0672	0.0672
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0088	0.0088
Schistosoma mansoni	myosin xvIII	0.0205	0.0672	0.0672
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0065	0.0104	0.0391
Echinococcus multilocularis	serotonin receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Toxoplasma gondii	hypothetical protein	0.0129	0.0365	0.0506
Schistosoma mansoni	hypothetical protein	0.0045	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Mycobacterium ulcerans	putative regulatory protein	0.0047	0.0031	0.5
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0066	0.011	0.04
Echinococcus multilocularis	CAAX prenyl protease 2	0.0181	0.0575	0.0575
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0147	0.0439	0.7615
Brugia malayi	Trypsin family protein	0.0093	0.0218	0.0817
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0061	0.0061
Echinococcus multilocularis	nmda type glutamate receptor	0.013	0.0366	0.0366
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0181	0.0575	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0205	0.0672	0.0672
Schistosoma mansoni	hypothetical protein	0.0045	0.0021	0.0021
Plasmodium falciparum	GAF domain-related protein, putative	0.0047	0.0031	0.5
Brugia malayi	Glutamate receptor 2 precursor	0.0438	0.1621	0.6074
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0205	0.0672	0.0672
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus multilocularis	expressed protein	0.0409	0.15	0.15
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0205	0.0672	0.2519
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.01	0.0248	0.4281
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0134	0.0491
Brugia malayi	RE15519p	0.0205	0.0672	0.2519
Echinococcus multilocularis	glutamate receptor 4	0.0088	0.0199	0.0199
Echinococcus multilocularis	protein patched	0.0046	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Entamoeba histolytica	hypothetical protein	0.0066	0.011	0.1909
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0066	0.011	0.04
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0017	0.0053
Echinococcus granulosus	orexin receptor type 2	0.0205	0.0672	0.0672
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	hypothetical protein	0.0353	0.1273	0.1273
Entamoeba histolytica	CAAX prenyl protease family	0.0181	0.0575	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.004	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Brugia malayi	Dopamine receptor protein 1	0.0205	0.0672	0.2519
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0147	0.0439	0.0439
Schistosoma mansoni	hypothetical protein	0.0045	0.0021	0.0021
Schistosoma mansoni	glutamate receptor AMPA	0.035	0.1262	0.1262
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0205	0.0672	0.0672
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0065	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0031	0.0104
Echinococcus granulosus	tm gpcr rhodopsin	0.0205	0.0672	0.0672
Loa Loa (eye worm)	G-protein coupled receptor	0.0205	0.0672	0.2511
Echinococcus granulosus	furin	0.017	0.0531	0.0531
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0181	0.0575	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0009	0.0023
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0066	0.011	0.04
Echinococcus multilocularis	tyrosine kinase	0.0066	0.011	0.011
Echinococcus multilocularis	neuropeptide receptor	0.2501	1	1
Onchocerca volvulus		0.0205	0.0672	1
Brugia malayi	hypothetical protein	0.0205	0.0672	0.2519
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.017	0.0531	0.0531
Brugia malayi	hypothetical protein	0.0066	0.011	0.0411
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0783	0.3021	0.3021
Schistosoma mansoni	hypothetical protein	0.0353	0.1273	0.1273
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0205	0.0672	0.2511
Brugia malayi	G protein-coupled receptor	0.0205	0.0672	0.2519
Brugia malayi	Glutamate receptor 1 precursor	0.0438	0.1621	0.6074
Schistosoma mansoni	ATP-binding cassette transporter	0.035	0.1262	0.1262
Echinococcus multilocularis	small conductance calcium activated potassium	0.019	0.0611	0.0611
Echinococcus multilocularis	fmrfamide receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	sex peptide receptor	0.0205	0.0672	0.0672
Echinococcus granulosus	neuropeptide Y receptor	0.0205	0.0672	0.0672
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0093	0.0218	0.0218
Echinococcus granulosus	glutamate receptor 2	0.0505	0.1891	0.1891
Brugia malayi	endoprotease bli-4 precursor	0.017	0.0531	0.1988
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0104	0.038
Loa Loa (eye worm)	hypothetical protein	0.0696	0.2669	1
Schistosoma mansoni	opsin-like receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0147	0.0439	0.7615
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	neuropeptide receptor	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0672	0.2511
Echinococcus granulosus	neuropeptide s receptor	0.0205	0.0672	0.0672
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0496	0.1855	0.1855
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0205	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0066	0.011	0.04

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.99 uM	Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assay	ChEMBL.	21189023
Inhibition (functional)	= 52 %	Growth inhibition of human MDA-MB-231 cells at 10 uM after 72 hrs by luminescence assay	ChEMBL.	21189023
Inhibition (binding)	= 85 %	Inhibition of human recombinant PDE5 at 10 uM after 30 mins by fluorescence polarization assay	ChEMBL.	21189023

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1650868

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1488057