Detailed information for compound 148813

Basic information

Technical information
  • TDR Targets ID: 148813
  • Name: [4-[(2R,3S)-2,3-dimethyl-4-[2-nitro-4,5-di(pr opanoyloxy)phenyl]butyl]-5-nitro-2-propanoylo xyphenyl] propanoate
  • MW: 616.613 | Formula: C30H36N2O12
  • H donors: 0 H acceptors: 8 LogP: 6.27 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC(=O)Oc1cc(C[C@H]([C@H](Cc2cc(OC(=O)CC)c(cc2[N+](=O)[O-])OC(=O)CC)C)C)c(cc1OC(=O)CC)[N+](=O)[O-]
  • InChi: 1S/C30H36N2O12/c1-7-27(33)41-23-13-19(21(31(37)38)15-25(23)43-29(35)9-3)11-17(5)18(6)12-20-14-24(42-28(34)8-2)26(44-30(36)10-4)16-22(20)32(39)40/h13-18H,7-12H2,1-6H3/t17-,18+
  • InChiKey: CKMCPOBGPUFNMW-HDICACEKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[(2R,3S)-2,3-dimethyl-4-[2-nitro-4,5-di(propanoyloxy)phenyl]butyl]-5-nitro-2-propanoyloxy-phenyl] propanoate
  • propanoic acid [4-[(2R,3S)-2,3-dimethyl-4-[2-nitro-4,5-bis(1-oxopropoxy)phenyl]butyl]-5-nitro-2-(1-oxopropoxy)phenyl] ester
  • propionic acid [4-[(2R,3S)-2,3-dimethyl-4-(2-nitro-4,5-dipropionyloxy-phenyl)butyl]-5-nitro-2-propionyloxy-phenyl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0268 0.0838
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Onchocerca volvulus Putative organic anion transporter 0.0024 0.0452 0.1416
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0135 0.3193 1
Schistosoma mansoni amine GPCR 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi Uncoordinated protein 44 0.0007 0.004 0.0126
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni organic anion transporter 0.0024 0.0452 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Brugia malayi GnHR receptor homolog 0.0092 0.2132 0.6677
Echinococcus multilocularis follistatin 0.0016 0.0268 0.1256
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi sodium-independent organic anion transporter family protein 0.0024 0.0452 0.1416
Schistosoma mansoni neuropeptide F-like receptor 0.0092 0.2132 0.2132
Brugia malayi hypothetical protein 0.0024 0.0452 0.1416
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis fmrfamide receptor 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.1416
Echinococcus granulosus fmrfamide receptor 0.0092 0.2132 1
Brugia malayi ORL1-like opioid receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0092 0.2132 0.6677
Schistosoma mansoni netrin receptor unc5 0.0007 0.004 0.004
Echinococcus multilocularis fmrfamide receptor 0.0092 0.2132 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0092 0.2132 1
Echinococcus granulosus serotonin receptor 0.0092 0.2132 1
Echinococcus granulosus sex peptide receptor 0.0092 0.2132 1
Echinococcus granulosus agrin 0.0016 0.0268 0.1256
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0092 0.2132 1
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis sodium bile acid cotransporter 0.0023 0.0448 0.2101
Echinococcus granulosus neuropeptides capa receptor 0.0092 0.2132 1
Echinococcus granulosus 6 phosphofructokinase 0.0014 0.0222 0.1043
Echinococcus multilocularis orexin receptor type 2 0.0092 0.2132 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0092 0.2132 1
Schistosoma mansoni opsin-like receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0092 0.2132 1
Brugia malayi hypothetical protein 0.001 0.0121 0.0378
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis g-protein coupled receptor 0.0092 0.2132 1
Schistosoma mansoni hypothetical protein 0.0092 0.2132 0.2132
Schistosoma mansoni hypothetical protein 0.0007 0.004 0.004
Echinococcus multilocularis sex peptide receptor 0.0092 0.2132 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Onchocerca volvulus 0.0092 0.2132 0.6677
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0092 0.2132 0.6677
Brugia malayi putative neuropeptide receptor NPR1 0.0092 0.2132 0.6677
Echinococcus granulosus netrin receptor unc 5 0.0007 0.004 0.0188
Schistosoma mansoni sodium-bile acid cotransporter related 0.0023 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.1416
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0092 0.2132 0.6677
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.001 0.0121 0.0567
Echinococcus granulosus Solute carrier organic anion transporter family 0.0024 0.0452 0.2121
Echinococcus multilocularis allatostatin A receptor 0.0092 0.2132 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis serotonin receptor 0.0092 0.2132 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0023 0.0448 0.2101
Brugia malayi G protein-coupled receptor 0.0092 0.2132 0.6677
Schistosoma mansoni amine GPCR 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0268 0.0838
Schistosoma mansoni ankyrin 23/unc44 0.0007 0.004 0.004
Schistosoma mansoni myosin xvIII 0.0092 0.2132 0.2132
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0092 0.2132 0.6677
Brugia malayi Tachykinin-like peptides receptor 99D 0.0092 0.2132 0.6677
Echinococcus multilocularis 6 phosphofructokinase 0.0014 0.0222 0.1043
Echinococcus multilocularis g protein coupled receptor 0.0092 0.2132 1
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0024 0.0452 0.2121
Brugia malayi follicle stimulating hormone receptor 0.0092 0.2132 0.6677
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0222 0.5
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi Dopamine receptor protein 2 0.0092 0.2132 0.6677
Echinococcus granulosus dro:myosuppressin receptor 0.0092 0.2132 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0092 0.2132 0.2132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis neuropeptide s receptor 0.0092 0.2132 1
Brugia malayi G-protein coupled receptor 0.0092 0.2132 0.6677
Echinococcus granulosus biogenic amine 5HT receptor 0.0092 0.2132 1
Loa Loa (eye worm) G-protein coupled receptor 0.0092 0.2132 0.6677
Leishmania major ATP-dependent phosphofructokinase 0.0014 0.0222 0.5
Schistosoma mansoni 6-phosphofructokinase 0.0014 0.0222 0.0222
Brugia malayi sodium-independent organic anion transporter family protein 0.0024 0.0452 0.1416
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0092 0.2132 0.6677
Brugia malayi Sodium Bile acid symporter family protein 0.0023 0.0448 0.1403
Echinococcus multilocularis dro:myosuppressin receptor 0.0092 0.2132 1
Schistosoma mansoni opsin-like receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) neuropeptide F receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0092 0.2132 0.2132
Brugia malayi neuropeptide F receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0024 0.0452 0.1416
Schistosoma mansoni neuropeptide f receptor 76f 0.0092 0.2132 0.2132
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0092 0.2132 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0092 0.2132 1
Brugia malayi Serotonin receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0092 0.2132 0.2132
Echinococcus granulosus follistatin 0.0016 0.0268 0.1256
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0007 0.004 0.0188
Trypanosoma cruzi MFS transporter, putative 0.0024 0.0452 1
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0222 0.5
Onchocerca volvulus 0.0092 0.2132 0.6677
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0035 0.0738 0.3463
Brugia malayi 6-phosphofructokinase 0.0014 0.0222 0.0696
Entamoeba histolytica phosphofructokinase, putative 0.0014 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0092 0.2132 0.2132
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0268 0.0838
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0023 0.0448 0.1403
Loa Loa (eye worm) TYRA-2 protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0092 0.2132 1
Brugia malayi SPARC precursor 0.0016 0.0268 0.0838
Loa Loa (eye worm) hypothetical protein 0.0023 0.0448 0.1403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0092 0.2132 0.6677
Schistosoma mansoni hypothetical protein 0.0092 0.2132 0.2132
Schistosoma mansoni hypothetical protein 0.0092 0.2132 0.2132
Echinococcus granulosus sodium bile acid cotransporter 0.0023 0.0448 0.2101
Loa Loa (eye worm) hypothetical protein 0.0007 0.0042 0.013
Brugia malayi G protein-coupled receptor F59B2.13 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Echinococcus granulosus hypothetical protein 0.0092 0.2132 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0092 0.2132 1
Onchocerca volvulus 0.0092 0.2132 0.6677
Brugia malayi larval opioid receptor 0.0092 0.2132 0.6677
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0014 0.0222 0.5
Loa Loa (eye worm) 6-phosphofructokinase 0.0014 0.0222 0.0696
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0024 0.0452 0.1416
Schistosoma mansoni neuropeptide receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis agrin 0.0016 0.0268 0.1256
Schistosoma mansoni biogenic amine (5HT) receptor 0.0092 0.2132 0.2132
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Echinococcus granulosus neuropeptide Y receptor 0.0092 0.2132 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0014 0.0222 0.0696
Schistosoma mansoni opsin-like receptor 0.0092 0.2132 0.2132
Schistosoma mansoni biogenic amine receptor 0.0092 0.2132 0.2132
Echinococcus granulosus peptide allatostatin:somatostatin 0.0092 0.2132 1
Brugia malayi sulfakinin receptor protein 0.0092 0.2132 0.6677
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus allatostatin A receptor 0.0092 0.2132 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0092 0.2132 1
Brugia malayi neuropeptide F receptor 0.0092 0.2132 0.6677
Schistosoma mansoni biogenic amine receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis neuropeptide Y receptor 0.0092 0.2132 1
Schistosoma mansoni 6-phosphofructokinase 0.0014 0.0222 0.0222
Echinococcus multilocularis neuropeptides capa receptor 0.0092 0.2132 1
Onchocerca volvulus 0.0092 0.2132 0.6677
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0222 0.5
Schistosoma mansoni organic anion transporter 0.0024 0.0452 0.0452
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0092 0.2132 0.2132
Onchocerca volvulus 0.0092 0.2132 0.6677
Schistosoma mansoni neuropeptide F-like receptor 0.0092 0.2132 0.2132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.004 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Echinococcus granulosus neuropeptide Y receptor 0.0092 0.2132 1
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) G-protein coupled receptor 0.0092 0.2132 0.6677
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0092 0.2132 1
Echinococcus granulosus tm gpcr rhodopsin 0.0092 0.2132 1
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) melatonin receptor type 1A 0.0092 0.2132 0.6677
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) agrin synaptic family protein 0.0016 0.0268 0.0838
Echinococcus granulosus g protein coupled receptor 0.0092 0.2132 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0024 0.0452 0.1416
Echinococcus granulosus somatostatin receptor 0.0092 0.2132 1
Onchocerca volvulus 0.0024 0.0452 0.1416
Schistosoma mansoni amine GPCR 0.0092 0.2132 0.2132
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0092 0.2132 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Echinococcus granulosus g protein coupled receptor 0.0092 0.2132 1
Schistosoma mansoni histamine h1 receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Entamoeba histolytica phosphofructokinase, putative 0.0014 0.0222 1
Echinococcus multilocularis sodium bile acid cotransporter 0.0023 0.0448 0.2101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.1416
Loa Loa (eye worm) neuropeptide F receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.1416
Onchocerca volvulus 0.0092 0.2132 0.6677
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Echinococcus granulosus g-protein coupled receptor 0.0092 0.2132 1
Loa Loa (eye worm) phosphofructokinase 0.0014 0.0222 0.0696
Brugia malayi Serotonin receptor 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0016 0.0268 0.0838
Schistosoma mansoni neuropeptide receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.2132 1
Echinococcus granulosus neuropeptide receptor 0.0092 0.2132 1
Entamoeba histolytica phosphofructokinase, putative 0.0014 0.0222 1
Onchocerca volvulus Putative organic anion transporter 0.0135 0.3193 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni neuropeptide receptor 0.0092 0.2132 0.2132
Schistosoma mansoni hypothetical protein 0.001 0.0121 0.0121
Schistosoma mansoni adenoreceptor 0.0092 0.2132 0.2132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus neuropeptide FF receptor 2 0.0092 0.2132 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0092 0.2132 0.2132
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0092 0.2132 1
Onchocerca volvulus 0.0092 0.2132 0.6677
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.004 0.0126
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0268 0.0838
Echinococcus granulosus sodium bile acid cotransporter 0.0023 0.0448 0.2101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0092 0.2132 1
Onchocerca volvulus Putative organic anion transporter 0.0024 0.0452 0.1416
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0014 0.0222 0.5
Brugia malayi AKH receptor 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.1416
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Brugia malayi prostaglandin transporter 0.0135 0.3193 1
Schistosoma mansoni sodium-bile acid cotransporter related 0.0023 0.0448 0.0448
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0016 0.0268 0.0838
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis expressed protein 0.0016 0.0268 0.1256
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi hypothetical protein 0.0024 0.0452 0.1416
Loa Loa (eye worm) hypothetical protein 0.0024 0.0452 0.1416
Onchocerca volvulus 0.0024 0.0452 0.1416
Brugia malayi G-protein coupled receptor 0.0092 0.2132 0.6677
Echinococcus multilocularis netrin receptor unc 5 0.0007 0.004 0.0188
Echinococcus granulosus tm gpcr rhodopsin 0.0092 0.2132 1
Brugia malayi putative neuropeptide receptor 0.0092 0.2132 0.6677
Schistosoma mansoni amine GPCR 0.0092 0.2132 0.2132
Echinococcus granulosus neuropeptide receptor 0.0092 0.2132 1
Brugia malayi phosphofructokinase 0.0014 0.0222 0.0696
Loa Loa (eye worm) hypothetical protein 0.0016 0.0268 0.0838
Echinococcus granulosus 7TM GPCR rhodopsin 0.0092 0.2132 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0024 0.0452 0.2121
Brugia malayi Protein kinase domain containing protein 0.0007 0.004 0.0126
Echinococcus multilocularis neuropeptide receptor A26 0.0092 0.2132 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0035 0.0738 0.3463
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0092 0.2132 0.2132
Echinococcus multilocularis neuropeptides capa receptor 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus Neuropeptide F receptor homolog 0.0092 0.2132 0.6677
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0007 0.004 0.0188
Brugia malayi Dopamine receptor 0.0092 0.2132 0.6677
Echinococcus granulosus orexin receptor type 2 0.0092 0.2132 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0092 0.2132 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0092 0.2132 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0092 0.2132 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.0126
Brugia malayi secreted modular calcium-binding protein 1 0.0016 0.0268 0.0838
Onchocerca volvulus 0.0092 0.2132 0.6677
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.001 0.0121 0.0567
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0092 0.2132 0.6677
Echinococcus granulosus Ankyrin 0.0007 0.0042 0.0195
Brugia malayi Death domain containing protein 0.0007 0.004 0.0126
Echinococcus multilocularis neuropeptide receptor 0.0092 0.2132 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0092 0.2132 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0014 0.0222 0.5
Schistosoma mansoni hypothetical protein 0.0092 0.2132 0.2132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0092 0.2132 1
Onchocerca volvulus 0.0016 0.0268 0.0838
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0092 0.2132 0.6677
Trichomonas vaginalis phosphofructokinase, putative 0.0014 0.0222 0.5
Brugia malayi hypothetical protein 0.0092 0.2132 0.6677
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0007 0.0042 0.0042
Echinococcus multilocularis neuropeptide Y receptor 0.0092 0.2132 1
Schistosoma mansoni agrin 0.0016 0.0268 0.0268
Echinococcus granulosus neuropeptide receptor A26 0.0092 0.2132 1
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0016 0.0268 0.0838
Echinococcus granulosus neuropeptide s receptor 0.0092 0.2132 1
Onchocerca volvulus 0.0024 0.0452 0.1416
Schistosoma mansoni biogenic amine receptor 0.0092 0.2132 0.2132
Brugia malayi Melatonin receptor type 1A 0.0092 0.2132 0.6677
Echinococcus multilocularis g protein coupled receptor 0.0092 0.2132 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0092 0.2132 0.2132
Echinococcus multilocularis g protein coupled receptor 0.0092 0.2132 1
Echinococcus granulosus death domain containing protein 0.0007 0.004 0.0188
Schistosoma mansoni neuropeptide receptor 0.0092 0.2132 0.2132
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus G protein coupled receptor 139 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0014 0.0222 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.2132 1
Brugia malayi RE15519p 0.0092 0.2132 0.6677
Echinococcus multilocularis Ankyrin 0.0007 0.0042 0.0195
Onchocerca volvulus Netrin receptor homolog 0.0007 0.004 0.0126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0092 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Onchocerca volvulus 0.0024 0.0452 0.1416
Mycobacterium ulcerans 6-phosphofructokinase 0.0014 0.0222 0.5
Echinococcus multilocularis neuropeptide receptor 0.0092 0.2132 1
Schistosoma mansoni follistatin 0.0016 0.0268 0.0268
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0092 0.2132 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0092 0.2132 1
Echinococcus granulosus tm gpcr rhodopsin 0.0092 0.2132 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0024 0.0452 0.2121
Echinococcus multilocularis G protein coupled receptor 139 0.0092 0.2132 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Echinococcus granulosus neuropeptides capa receptor 0.0092 0.2132 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0092 0.2132 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0092 0.2132 0.2132
Echinococcus granulosus 7tm_1 domain containing protein 0.0092 0.2132 1
Echinococcus granulosus g protein coupled receptor 0.0092 0.2132 1
Brugia malayi Dopamine receptor protein 1 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0092 0.2132 0.6677
Echinococcus multilocularis serotonin receptor 0.0092 0.2132 1
Schistosoma mansoni transcription factor LCR-F1 0.001 0.0121 0.0121
Echinococcus multilocularis somatostatin receptor 0.0092 0.2132 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0092 0.2132 1
Onchocerca volvulus 0.0092 0.2132 0.6677
Loa Loa (eye worm) hypothetical protein 0.0016 0.0268 0.0838
Echinococcus granulosus sodium bile acid cotransporter 0.0023 0.0448 0.2101
Loa Loa (eye worm) hypothetical protein 0.0092 0.2132 0.6677
Brugia malayi 6-phosphofructokinase 0.0014 0.0223 0.0699
Toxoplasma gondii transporter, major facilitator family protein 0.0024 0.0452 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO) ChEMBL. 12036375
Inhibition (binding) = 0 % % inhibition against human platelet 12-lipoxygenase (12-HLO) ChEMBL. 12036375
Inhibition (binding) = 0 % % inhibition against soybean 1-lipoxygenase (SLO) ChEMBL. 12036375
Inhibition (binding) = 0 % Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO) ChEMBL. 12036375
Inhibition (binding) = 0 % % inhibition against human platelet 12-lipoxygenase (12-HLO) ChEMBL. 12036375
Inhibition (binding) = 0 % % inhibition against soybean 1-lipoxygenase (SLO) ChEMBL. 12036375

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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