TDR Targets

Basic information

Technical information

TDR Targets ID: 1489999
Name: 8-(3,4-dimethoxyphenyl)sulfonyl-4-(4-methylph enyl)sulfonyl-1-oxa-4,8-diazaspiro[4.5]decane
MW: 496.597 | Formula: C22H28N2O7S2
H donors: 0 H acceptors: 4 LogP: 2.32 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)S(=O)(=O)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccc(cc1)C
InChi: 1S/C22H28N2O7S2/c1-17-4-6-18(7-5-17)33(27,28)24-14-15-31-22(24)10-12-23(13-11-22)32(25,26)19-8-9-20(29-2)21(16-19)30-3/h4-9,16H,10-15H2,1-3H3
InChiKey: POXASAURWBKLRZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0022	0.0804
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0022	0.0022
Schistosoma mansoni	ap endonuclease	0.0019	0.0015	0.0015
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0053	0.0268	0.7854
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Loa Loa (eye worm)	TWK-28 protein	0.0053	0.0268	0.0268
Onchocerca volvulus		0.0019	0.0022	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Leishmania major	hypothetical protein, conserved	0.0053	0.0268	0.7854
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0015	0.0558
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0015	0.0438
Giardia lamblia	Hypothetical protein	0.0053	0.0268	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0022	0.0022
Mycobacterium ulcerans	ion transport protein	0.0053	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0022	0.0022
Onchocerca volvulus		0.0053	0.0268	1
Echinococcus multilocularis	calcium activated potassium channel variant	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0292	0.2027	0.2027
Echinococcus granulosus	geminin	0.0205	0.1382	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0053	0.0268	0.8784
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Schistosoma mansoni	lipoxygenase	0.0019	0.0022	0.0022
Echinococcus granulosus	potassium channel subfamily K 8	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.0305	0.0305
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0015	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0053	0.0268	0.8784
Schistosoma mansoni	hypothetical protein	0.0205	0.1382	0.1382
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0015	0.0015
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0053	0.0268	0.0268
Echinococcus multilocularis	twik family of potassium channels	0.0053	0.0268	0.0268
Echinococcus multilocularis	potassium channel subfamily K	0.0053	0.0268	0.0268
Echinococcus granulosus	RUN	0.0019	0.0022	0.0022
Loa Loa (eye worm)	TWK-7 protein	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Echinococcus multilocularis	potassium channel subfamily K 8	0.0053	0.0268	0.0268
Schistosoma mansoni	calcium-activated potassium channel	0.0053	0.0268	0.0268
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0053	0.0268	0.7854
Trypanosoma cruzi	ion transport protein, putative	0.0053	0.0268	0.7854
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0053	0.0268	0.8784
Brugia malayi	jmjC domain containing protein	0.0058	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Leishmania major	calcium/potassium channel (CAKC), putative	0.0053	0.0268	0.7854
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0053	0.0268	0.8784
Loa Loa (eye worm)	hypothetical protein	0.0488	0.3466	0.3466
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0053	0.0268	0.8784
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0053	0.0268	0.8784
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0053	0.0268	0.0268
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0015	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0022	0.0022
Mycobacterium ulcerans	transmembrane cation transporter	0.0053	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0053	0.0268	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0053	0.0268	0.7854
Leishmania major	ion transport protein-like protein	0.0053	0.0268	0.7854
Echinococcus granulosus	twik family of potassium channels	0.0053	0.0268	0.0268
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0022	0.0022
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0278	0.0278
Schistosoma mansoni	ap endonuclease	0.0019	0.0015	0.0015
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0015	0.0558
Leishmania major	cathepsin L-like protease	0.0063	0.0341	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0053	0.0268	0.7854
Loa Loa (eye worm)	uncoordinated protein 58	0.0053	0.0268	0.0268
Toxoplasma gondii	exonuclease III APE	0.0019	0.0015	0.0558
Plasmodium falciparum	potassium channel	0.0053	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Leishmania major	potassium channel subunit-like protein	0.0053	0.0268	0.7854
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0015	0.049
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0015	0.0438
Echinococcus granulosus	microtubule associated protein 2	0.068	0.4874	0.4874
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0022	0.0022
Echinococcus granulosus	twik family of potassium channels	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Echinococcus multilocularis	geminin	0.0205	0.1382	0.1382
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0053	0.0268	0.8784
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0242	0.7098
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma cruzi	hypothetical protein, conserved	0.0053	0.0268	0.7854
Onchocerca volvulus		0.0053	0.0268	1
Onchocerca volvulus		0.0019	0.0022	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0053	0.0268	0.7755
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Plasmodium falciparum	potassium channel	0.0053	0.0268	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0053	0.0268	0.8784
Brugia malayi	Cytochrome P450 family protein	0.0045	0.0206	0.6773
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.0305	0.0305
Onchocerca volvulus		0.0053	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Onchocerca volvulus		0.0053	0.0268	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0022	0.0022
Schistosoma mansoni	rab6-interacting	0.0019	0.0022	0.0022
Brugia malayi	jmjC domain containing protein	0.0058	0.0305	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0045	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0053	0.0268	0.8784
Brugia malayi	hypothetical protein	0.0019	0.0022	0.0707
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0053	0.0268	0.8784
Echinococcus multilocularis	twik family of potassium channels	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0053	0.0268	0.8784
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0268	1
Onchocerca volvulus		0.0053	0.0268	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0015	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0053	0.0268	0.8784
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0022	0.0022
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0053	0.0268	0.7755
Toxoplasma gondii	ion channel protein	0.0053	0.0268	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0053	0.0268	0.8784
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.7072	0.7072
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Leishmania major	hypothetical protein, conserved	0.0053	0.0268	0.7854
Schistosoma mansoni	polycystin 1-related	0.0019	0.0022	0.0022
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0305	0.0305
Leishmania major	cathepsin L-like protease	0.0063	0.0341	1
Leishmania major	cathepsin L-like protease	0.0063	0.0341	1
Echinococcus granulosus	calcium activated potassium channel variant	0.0053	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Echinococcus multilocularis	small conductance calcium activated potassium	0.1378	1	1
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0053	0.0268	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Schistosoma mansoni	lipoxygenase	0.0054	0.0278	0.0278
Plasmodium vivax	potassium channel, putative	0.0053	0.0268	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0278	0.0278
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0053	0.0268	0.7854
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0341	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0268	1
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0053	0.0268	0.0268
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0341	1
Brugia malayi	hypothetical protein	0.0053	0.0268	0.8784
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0022	0.0804
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Loa Loa (eye worm)	hypothetical protein	0.0544	0.3876	0.3876
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0053	0.0268	0.0268
Brugia malayi	hypothetical protein	0.0053	0.0268	0.8784
Onchocerca volvulus		0.0053	0.0268	1
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0341	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0053	0.0268	0.8784
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0053	0.0268	0.8784
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0015	0.0558
Schistosoma mansoni	loxhd1	0.0019	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0019	0.0022	0.0707
Echinococcus multilocularis	potassium channel subfamily K 8	0.0053	0.0268	0.0268
Schistosoma mansoni	hypothetical protein	0.0019	0.0022	0.0022
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0015	0.0558
Brugia malayi	Doublecortin family protein	0.0019	0.0022	0.0707
Echinococcus granulosus	potassium channel subfamily K 8	0.0053	0.0268	0.0268
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Schistosoma mansoni	hypothetical protein	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Echinococcus multilocularis	RUN	0.0019	0.0022	0.0022
Schistosoma mansoni	twik family of potassium channels-related	0.0053	0.0268	0.0268
Schistosoma mansoni	hypothetical protein	0.0205	0.1382	0.1382
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0053	0.0268	0.8784
Toxoplasma gondii	ion channel protein	0.0053	0.0268	1
Schistosoma mansoni	microtubule-associated protein tau	0.068	0.4874	0.4874
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0053	0.0268	0.0268
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0015	0.0558
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0053	0.0268	0.8784
Trypanosoma cruzi	ion transport protein, putative	0.0053	0.0268	0.7854
Echinococcus multilocularis	microtubule associated protein 2	0.068	0.4874	0.4874
Schistosoma mansoni	hypothetical protein	0.1378	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0268	1
Schistosoma mansoni	rab6-interacting	0.0019	0.0022	0.0022
Plasmodium vivax	potassium channel, putative	0.0053	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.1378	1	1
Schistosoma mansoni	calcium-activated potassium channel	0.1378	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Onchocerca volvulus		0.0053	0.0268	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0305	0.0305
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.0305	0.0305
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0053	0.0268	0.0268
Schistosoma mansoni	calcium-activated potassium channel	0.0053	0.0268	0.0268
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0341	1
Echinococcus granulosus	potassium channel subfamily K	0.0053	0.0268	0.0268
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0053	0.0268	0.0268
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0268	0.0268
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0053	0.0268	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0305	0.0305
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0301	0.8824
Schistosoma mansoni	calcium-activated potassium channel	0.1033	0.7463	0.7463
Onchocerca volvulus		0.0053	0.0268	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.5918 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	9.2 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1698728

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1489999