Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.1999 | 0.2378 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.1999 | 0.1999 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.1999 | 0.1999 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.1999 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.1999 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.1999 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.086 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.1999 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.086 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0747 | 0.8407 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.086 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.086 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1999 | 1 |
Onchocerca volvulus | 0.0292 | 0.1999 | 0.5 | |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0747 | 0.8407 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.1999 | 0.1999 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.1999 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14 nM | Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometry | ChEMBL. | 21185183 |
Ki (binding) | = 198 nM | Displacement of [3H]nisoxetine from human NET by scintillation proximity assay | ChEMBL. | 21185183 |
Ki (binding) | = 1710 nM | Displacement of [3H]citalopram from human SERT by scintillation proximity assay | ChEMBL. | 21185183 |
Ki (binding) | = 4700 nM | Displacement of [3H]WIN-35,428 from human DAT by scintillation proximity assay | ChEMBL. | 21185183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.