Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, AMPA 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 9 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 9 | 490 aa | 441 aa | 21.8 % |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | glutamate receptor, ionotropic, AMPA 2 | 883 aa | 810 aa | 34.0 % |
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor 2 | 0.0087 | 0.1154 | 0.1453 |
Echinococcus granulosus | glutamate receptor 1 | 0.0051 | 0.0339 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.6015 | 1 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0051 | 0.0339 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1158 | 0.1443 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0081 | 0.1024 | 0.1289 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0172 | 0.3084 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0146 | 0.2491 | 0.2491 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0067 | 0.071 | 0.0655 |
Brugia malayi | cation channel family protein | 0.0204 | 0.3809 | 0.3335 |
Echinococcus granulosus | glutamate receptor 2 | 0.0087 | 0.1154 | 0.1453 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0081 | 0.1024 | 0.0338 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0055 | 0.0433 | 0.0433 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0062 | 0.0592 | 0.0746 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0087 | 0.1154 | 0.1453 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0076 | 0.0901 | 0.1134 |
Echinococcus granulosus | glutamate receptor 4 | 0.0051 | 0.0339 | 0.0427 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0387 | 0.7942 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0076 | 0.0901 | 0.1134 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0387 | 0.7942 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1243 | 0.1592 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0302 | 0.6015 | 0.7574 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0302 | 0.6015 | 0.7574 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0062 | 0.0592 | 0.0746 |
Schistosoma mansoni | ryanodine receptor related | 0.0478 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0087 | 0.1154 | 0.1453 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0081 | 0.1024 | 0.1207 |
Loa Loa (eye worm) | ryanodine receptor | 0.0113 | 0.1737 | 0.2463 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.1852 | 0.1852 |
Loa Loa (eye worm) | ryanodine receptor | 0.0179 | 0.3225 | 0.5084 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0172 | 0.3084 | 0.5 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0081 | 0.1024 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0502 | 0.0288 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.1836 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0058 | 0.0502 | 0.0502 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 81 % | Allosteric modulation of human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium influx by Fluo-4/FLIPR method relative to cyclothiazide | ChEMBL. | 21128618 |
EC50 (binding) | > 4.7 | Allosteric modulation of human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium influx by Fluo-4/FLIPR method | ChEMBL. | 21128618 |
IC50 (ADMET) | > 10 uM | Inhibition of human CYP2C19 by fluorescence assay | ChEMBL. | 21128618 |
IC50 (ADMET) | > 10 uM | Inhibition of human CYP3A4 by fluorescence assay | ChEMBL. | 21128618 |
IC50 (ADMET) | > 10 uM | Inhibition of human CYP1A2 by fluorescence assay | ChEMBL. | 21128618 |
IC50 (ADMET) | > 10 uM | Inhibition of human CYP2C9 by fluorescence assay | ChEMBL. | 21128618 |
IC50 (ADMET) | > 10 uM | Inhibition of human CYP2D6 by fluorescence assay | ChEMBL. | 21128618 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.