Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0286 | 0.2493 | 0.2702 |
Onchocerca volvulus | 0.0901 | 1 | 1 | |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0092 | 0.0128 | 0.0128 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0092 | 0.0128 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0901 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0.0128 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0092 | 0.0128 | 0.5 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0092 | 0.0128 | 0.0128 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0901 | 1 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0092 | 0.0128 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0809 | 0.8881 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0092 | 0.0128 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0092 | 0.0128 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.2493 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0.0128 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0809 | 0.8881 | 0.8867 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0092 | 0.0128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2493 | 0.2702 |
Brugia malayi | acyl-CoA desaturase | 0.0809 | 0.8881 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0809 | 0.8881 | 0.8867 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0092 | 0.0128 | 0.0128 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.2493 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0092 | 0.0128 | 0.5 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0092 | 0.0128 | 0.0128 |
Schistosoma mansoni | fatty acid desaturase | 0.0092 | 0.0128 | 1 |
Onchocerca volvulus | 0.0901 | 1 | 1 | |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0092 | 0.0128 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0809 | 0.8881 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0901 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0809 | 0.8881 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0092 | 0.0128 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.