Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 7 (5-HT7) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus granulosus | biogenic amine 5HT receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0444 | 0.5254 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0086 | 0.0086 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0845 | 1 |
Entamoeba histolytica | alpha-amylase family protein | 0.0078 | 0.1395 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0845 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0035 | 0.0444 | 0.4712 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0078 | 0.1395 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0845 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0845 | 1 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0035 | 0.0444 | 0.0444 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Mycobacterium ulcerans | glycogen branching protein | 0.0035 | 0.0444 | 1 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0035 | 0.0444 | 0.5254 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0845 | 1 |
Treponema pallidum | ATP-binding protein (ylxH-1) | 0.0243 | 0.5028 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0086 | 0.0086 |
Trichomonas vaginalis | amylase, putative | 0.0078 | 0.1395 | 1 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0035 | 0.0444 | 0.4712 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0086 | 0.1023 |
Toxoplasma gondii | glycosyltransferase | 0.0035 | 0.0444 | 0.4712 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trichomonas vaginalis | alpha-amylase, putative | 0.0078 | 0.1395 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0845 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0845 | 1 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0035 | 0.0444 | 0.2732 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0469 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trichomonas vaginalis | alpha-amylase, putative | 0.0078 | 0.1395 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trichomonas vaginalis | amylase, putative | 0.0078 | 0.1395 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0069 | 0.1208 | 0.857 |
Trichomonas vaginalis | amylase, putative | 0.0035 | 0.0444 | 0.2732 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0035 | 0.0444 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0845 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0845 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0018 | 0.0086 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0035 | 0.0444 | 0.0444 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0469 | 1 | 1 |
Schistosoma mansoni | starch branching enzyme II | 0.0035 | 0.0444 | 0.0444 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Mycobacterium tuberculosis | 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) | 0.0035 | 0.0444 | 0.4712 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0845 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0086 | 0.5 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0845 | 1 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0845 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0086 | 0.0086 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0845 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0078 | 0.1395 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0845 | 0.0845 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0086 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0845 | 0.0845 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0035 | 0.0444 | 1 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Entamoeba histolytica | alpha-amylase family protein | 0.0078 | 0.1395 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.59 | Affinity for Alpha-2 adrenergic receptor of rat cortical membranes | ChEMBL. | 12482437 |
Ki (binding) | = -7.56 | Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes | ChEMBL. | 12482437 |
Ki (binding) | = -6.58 | Affinity for Alpha-1 adrenergic receptor of rat cortical membranes | ChEMBL. | 12482437 |
Log Ki (binding) | = 6.58 | Affinity for Alpha-1 adrenergic receptor of rat cortical membranes | ChEMBL. | 12482437 |
Log Ki (binding) | = 7.56 | Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes | ChEMBL. | 12482437 |
Log Ki (binding) | = 7.59 | Affinity for Alpha-2 adrenergic receptor of rat cortical membranes | ChEMBL. | 12482437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.