Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0099 | 0.0057 | 0.0057 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0131 | 0.251 | 0.251 |
Echinococcus multilocularis | serine:threonine protein kinase | 0.0131 | 0.251 | 0.251 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0131 | 0.251 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0099 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0099 | 0.0057 | 0.0226 |
Brugia malayi | Protein kinase domain containing protein | 0.0131 | 0.251 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0228 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0228 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0099 | 0.0057 | 0.0226 |
Loa Loa (eye worm) | CAMK/CAMKL/MARK protein kinase | 0.0131 | 0.251 | 1 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0131 | 0.251 | 0.2467 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0228 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.251 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0228 | 1 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0099 | 0.0057 | 0.0057 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0099 | 0.0057 | 0.0057 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0099 | 0.0057 | 0.0057 |
Echinococcus granulosus | serine:threonine protein kinase | 0.0131 | 0.251 | 0.2467 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.956 uM | PUBCHEM_BIOASSAY: SAR analysis of Agonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay-Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1786] | ChEMBL. | No reference |
EC50 (functional) | = 1.24 uM | PUBCHEM_BIOASSAY: SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1785, AID1786, AID1966, AID2133, AID2136, AID2284, AID2500] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR Analysis of Agonists of the MOR Receptor using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1785, AID1786, AID1966, AID2133, AID2136, AID2284, AID2285, AID2352] | ChEMBL. | No reference |
EC50 (functional) | > 64 uM | PUBCHEM_BIOASSAY: SAR Analysis of Agonists of the DOR Receptor using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1777, AID1786] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.